These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

131 related articles for article (PubMed ID: 27307197)

  • 1. Broadening substrate specificity of a chain-extending ketosynthase through a single active-site mutation.
    Murphy AC; Hong H; Vance S; Broadhurst RW; Leadlay PF
    Chem Commun (Camb); 2016 Jun; 52(54):8373-6. PubMed ID: 27307197
    [TBL] [Abstract][Full Text] [Related]  

  • 2. A close look at a ketosynthase from a trans-acyltransferase modular polyketide synthase.
    Gay DC; Gay G; Axelrod AJ; Jenner M; Kohlhaas C; Kampa A; Oldham NJ; Piel J; Keatinge-Clay AT
    Structure; 2014 Mar; 22(3):444-51. PubMed ID: 24508341
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Ketosynthase Domain Constrains the Design of Polyketide Synthases.
    Klaus M; Buyachuihan L; Grininger M
    ACS Chem Biol; 2020 Sep; 15(9):2422-2432. PubMed ID: 32786257
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Roles of Conserved Active Site Residues in the Ketosynthase Domain of an Assembly Line Polyketide Synthase.
    Robbins T; Kapilivsky J; Cane DE; Khosla C
    Biochemistry; 2016 Aug; 55(32):4476-84. PubMed ID: 27441852
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Substrate specificity in ketosynthase domains from trans-AT polyketide synthases.
    Jenner M; Frank S; Kampa A; Kohlhaas C; Pöplau P; Briggs GS; Piel J; Oldham NJ
    Angew Chem Int Ed Engl; 2013 Jan; 52(4):1143-7. PubMed ID: 23212972
    [No Abstract]   [Full Text] [Related]  

  • 6. Structural Insight into the Reaction Mechanism of Ketosynthase-Like Decarboxylase in a Loading Module of Modular Polyketide Synthases.
    Chisuga T; Nagai A; Miyanaga A; Goto E; Kishikawa K; Kudo F; Eguchi T
    ACS Chem Biol; 2022 Jan; 17(1):198-206. PubMed ID: 34985877
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Protein-Protein Interactions, Not Substrate Recognition, Dominate the Turnover of Chimeric Assembly Line Polyketide Synthases.
    Klaus M; Ostrowski MP; Austerjost J; Robbins T; Lowry B; Cane DE; Khosla C
    J Biol Chem; 2016 Jul; 291(31):16404-15. PubMed ID: 27246853
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Production of dihydroisocoumarins in Fusarium verticillioides by swapping ketosynthase domain of the fungal iterative polyketide synthase Fum1p with that of lovastatin diketide synthase.
    Zhu X; Yu F; Li XC; Du L
    J Am Chem Soc; 2007 Jan; 129(1):36-7. PubMed ID: 17199276
    [No Abstract]   [Full Text] [Related]  

  • 9. Reconstituting modular activity from separated domains of 6-deoxyerythronolide B synthase.
    Kim CY; Alekseyev VY; Chen AY; Tang Y; Cane DE; Khosla C
    Biochemistry; 2004 Nov; 43(44):13892-8. PubMed ID: 15518537
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Ketoreduction in mycolactone biosynthesis: insight into substrate specificity and stereocontrol from studies of discrete ketoreductase domains in vitro.
    Bali S; Weissman KJ
    Chembiochem; 2006 Dec; 7(12):1935-42. PubMed ID: 17031885
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Prediction of inter domain interactions in modular polyketide synthases by docking and correlated mutation analysis.
    Yadav G; Anand S; Mohanty D
    J Biomol Struct Dyn; 2013; 31(1):17-29. PubMed ID: 22803697
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Analysis of covalently bound polyketide intermediates on 6-deoxyerythronolide B synthase by tandem proteolysis-mass spectrometry.
    Schnarr NA; Chen AY; Cane DE; Khosla C
    Biochemistry; 2005 Sep; 44(35):11836-42. PubMed ID: 16128585
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Lichen ketosynthase domains are not responsible for inoperative polyketide synthases in Ascomycota hosts.
    Abdel-Hameed ME; Bertrand RL; Donald LJ; Sorensen JL
    Biochem Biophys Res Commun; 2018 Sep; 503(3):1228-1234. PubMed ID: 30007436
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The changing patterns of covalent active site occupancy during catalysis on a modular polyketide synthase multienzyme revealed by ion-trap mass spectrometry.
    Hong H; Leadlay PF; Staunton J
    FEBS J; 2009 Dec; 276(23):7057-69. PubMed ID: 19860832
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Enzyme-directed mutasynthesis: a combined experimental and theoretical approach to substrate recognition of a polyketide synthase.
    Sundermann U; Bravo-Rodriguez K; Klopries S; Kushnir S; Gomez H; Sanchez-Garcia E; Schulz F
    ACS Chem Biol; 2013 Feb; 8(2):443-50. PubMed ID: 23181268
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Acyl-chain elongation drives ketosynthase substrate selectivity in trans-acyltransferase polyketide synthases.
    Jenner M; Afonso JP; Bailey HR; Frank S; Kampa A; Piel J; Oldham NJ
    Angew Chem Int Ed Engl; 2015 Feb; 54(6):1817-21. PubMed ID: 25529827
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Unique features of the ketosynthase domain in a nonribosomal peptide synthetase-polyketide synthase hybrid enzyme, tenuazonic acid synthetase 1.
    Yun CS; Nishimoto K; Motoyama T; Shimizu T; Hino T; Dohmae N; Nagano S; Osada H
    J Biol Chem; 2020 Aug; 295(33):11602-11612. PubMed ID: 32565425
    [TBL] [Abstract][Full Text] [Related]  

  • 18. A mechanism-based fluorescence transfer assay for examining ketosynthase selectivity.
    Prasad G; Borketey LS; Lin TY; Schnarr NA
    Org Biomol Chem; 2012 Sep; 10(33):6717-23. PubMed ID: 22806124
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structural and functional analysis of the loading acyltransferase from avermectin modular polyketide synthase.
    Wang F; Wang Y; Ji J; Zhou Z; Yu J; Zhu H; Su Z; Zhang L; Zheng J
    ACS Chem Biol; 2015 Apr; 10(4):1017-25. PubMed ID: 25581064
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Insights into polyketide biosynthesis gained from repurposing antibiotic-producing polyketide synthases to produce fuels and chemicals.
    Yuzawa S; Keasling JD; Katz L
    J Antibiot (Tokyo); 2016 Jul; 69(7):494-9. PubMed ID: 27245558
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.