BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

1607 related articles for article (PubMed ID: 27310874)

  • 1. Bax/Bak activation in the absence of Bid, Bim, Puma, and p53.
    Zhang J; Huang K; O'Neill KL; Pang X; Luo X
    Cell Death Dis; 2016 Jun; 7(6):e2266. PubMed ID: 27310874
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The BH3 alpha-helical mimic BH3-M6 disrupts Bcl-X(L), Bcl-2, and MCL-1 protein-protein interactions with Bax, Bak, Bad, or Bim and induces apoptosis in a Bax- and Bim-dependent manner.
    Kazi A; Sun J; Doi K; Sung SS; Takahashi Y; Yin H; Rodriguez JM; Becerril J; Berndt N; Hamilton AD; Wang HG; Sebti SM
    J Biol Chem; 2011 Mar; 286(11):9382-92. PubMed ID: 21148306
    [TBL] [Abstract][Full Text] [Related]  

  • 3. BID, BIM, and PUMA are essential for activation of the BAX- and BAK-dependent cell death program.
    Ren D; Tu HC; Kim H; Wang GX; Bean GR; Takeuchi O; Jeffers JR; Zambetti GP; Hsieh JJ; Cheng EH
    Science; 2010 Dec; 330(6009):1390-3. PubMed ID: 21127253
    [TBL] [Abstract][Full Text] [Related]  

  • 4. An interconnected hierarchical model of cell death regulation by the BCL-2 family.
    Chen HC; Kanai M; Inoue-Yamauchi A; Tu HC; Huang Y; Ren D; Kim H; Takeda S; Reyna DE; Chan PM; Ganesan YT; Liao CP; Gavathiotis E; Hsieh JJ; Cheng EH
    Nat Cell Biol; 2015 Oct; 17(10):1270-81. PubMed ID: 26344567
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Mcl-1 and Bcl-x
    Hockings C; Alsop AE; Fennell SC; Lee EF; Fairlie WD; Dewson G; Kluck RM
    Cell Death Differ; 2018 Mar; 25(4):721-734. PubMed ID: 29459767
    [TBL] [Abstract][Full Text] [Related]  

  • 6. BH3-only proteins target BCL-xL/MCL-1, not BAX/BAK, to initiate apoptosis.
    Huang K; O'Neill KL; Li J; Zhou W; Han N; Pang X; Wu W; Struble L; Borgstahl G; Liu Z; Zhang L; Luo X
    Cell Res; 2019 Nov; 29(11):942-952. PubMed ID: 31551537
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Hierarchical regulation of mitochondrion-dependent apoptosis by BCL-2 subfamilies.
    Kim H; Rafiuddin-Shah M; Tu HC; Jeffers JR; Zambetti GP; Hsieh JJ; Cheng EH
    Nat Cell Biol; 2006 Dec; 8(12):1348-58. PubMed ID: 17115033
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Dual inhibition of Bcl-2 and Bcl-xL strikingly enhances PI3K inhibition-induced apoptosis in human myeloid leukemia cells through a GSK3- and Bim-dependent mechanism.
    Rahmani M; Aust MM; Attkisson E; Williams DC; Ferreira-Gonzalez A; Grant S
    Cancer Res; 2013 Feb; 73(4):1340-51. PubMed ID: 23243017
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synergistic induction of apoptosis by p53-inducible Bcl-2 family proteins Noxa and Puma.
    Nakajima W; Tanaka N
    J Nippon Med Sch; 2007 Apr; 74(2):148-57. PubMed ID: 17507791
    [TBL] [Abstract][Full Text] [Related]  

  • 10. p14(ARF)-induced apoptosis in p53 protein-deficient cells is mediated by BH3-only protein-independent derepression of Bak protein through down-regulation of Mcl-1 and Bcl-xL proteins.
    Müer A; Overkamp T; Gillissen B; Richter A; Pretzsch T; Milojkovic A; Dörken B; Daniel PT; Hemmati P
    J Biol Chem; 2012 May; 287(21):17343-17352. PubMed ID: 22354970
    [TBL] [Abstract][Full Text] [Related]  

  • 11. BH3-only activator proteins Bid and Bim are dispensable for Bak/Bax-dependent thrombocyte apoptosis induced by Bcl-xL deficiency: molecular requisites for the mitochondrial pathway to apoptosis in platelets.
    Kodama T; Takehara T; Hikita H; Shimizu S; Shigekawa M; Li W; Miyagi T; Hosui A; Tatsumi T; Ishida H; Kanto T; Hiramatsu N; Yin XM; Hayashi N
    J Biol Chem; 2011 Apr; 286(16):13905-13. PubMed ID: 21367852
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Stepwise activation of BAX and BAK by tBID, BIM, and PUMA initiates mitochondrial apoptosis.
    Kim H; Tu HC; Ren D; Takeuchi O; Jeffers JR; Zambetti GP; Hsieh JJ; Cheng EH
    Mol Cell; 2009 Nov; 36(3):487-99. PubMed ID: 19917256
    [TBL] [Abstract][Full Text] [Related]  

  • 13. BH3-only protein bid participates in the Bcl-2 network in healthy liver cells.
    Hikita H; Takehara T; Kodama T; Shimizu S; Hosui A; Miyagi T; Tatsumi T; Ishida H; Ohkawa K; Li W; Kanto T; Hiramatsu N; Hennighausen L; Yin XM; Hayashi N
    Hepatology; 2009 Dec; 50(6):1972-80. PubMed ID: 19839062
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax.
    Hockings C; Anwari K; Ninnis RL; Brouwer J; O'Hely M; Evangelista M; Hinds MG; Czabotar PE; Lee EF; Fairlie WD; Dewson G; Kluck RM
    Cell Death Dis; 2015 Apr; 6(4):e1735. PubMed ID: 25906158
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane.
    O'Neill KL; Huang K; Zhang J; Chen Y; Luo X
    Genes Dev; 2016 Apr; 30(8):973-88. PubMed ID: 27056669
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Genetically defining the mechanism of Puma- and Bim-induced apoptosis.
    Garrison SP; Phillips DC; Jeffers JR; Chipuk JE; Parsons MJ; Rehg JE; Opferman JT; Green DR; Zambetti GP
    Cell Death Differ; 2012 Apr; 19(4):642-9. PubMed ID: 22015606
    [TBL] [Abstract][Full Text] [Related]  

  • 17. BH3 domains other than Bim and Bid can directly activate Bax/Bak.
    Du H; Wolf J; Schafer B; Moldoveanu T; Chipuk JE; Kuwana T
    J Biol Chem; 2011 Jan; 286(1):491-501. PubMed ID: 21041309
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Mcl-1 down-regulation potentiates ABT-737 lethality by cooperatively inducing Bak activation and Bax translocation.
    Chen S; Dai Y; Harada H; Dent P; Grant S
    Cancer Res; 2007 Jan; 67(2):782-91. PubMed ID: 17234790
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak.
    Willis SN; Fletcher JI; Kaufmann T; van Delft MF; Chen L; Czabotar PE; Ierino H; Lee EF; Fairlie WD; Bouillet P; Strasser A; Kluck RM; Adams JM; Huang DC
    Science; 2007 Feb; 315(5813):856-9. PubMed ID: 17289999
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Distinct lipid effects on tBid and Bim activation of membrane permeabilization by pro-apoptotic Bax.
    Shamas-Din A; Bindner S; Chi X; Leber B; Andrews DW; Fradin C
    Biochem J; 2015 May; 467(3):495-505. PubMed ID: 25714678
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 81.