BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

123 related articles for article (PubMed ID: 27318552)

  • 1. Structural modifications of the serotonin 5-HT7 receptor agonist N-(4-cyanophenylmethyl)-4-(2-biphenyl)-1-piperazinehexanamide (LP-211) to improve in vitro microsomal stability: A case study.
    Lacivita E; Podlewska S; Speranza L; Niso M; Satała G; Perrone R; Perrone-Capano C; Bojarski AJ; Leopoldo M
    Eur J Med Chem; 2016 Sep; 120():363-79. PubMed ID: 27318552
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structural modifications of N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinehexanamides: influence on lipophilicity and 5-HT7 receptor activity. Part III.
    Leopoldo M; Lacivita E; De Giorgio P; Fracasso C; Guzzetti S; Caccia S; Contino M; Colabufo NA; Berardi F; Perrone R
    J Med Chem; 2008 Sep; 51(18):5813-22. PubMed ID: 18800769
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Towards metabolically stable 5-HT7 receptor ligands: a study on 1-arylpiperazine derivatives and related isosters.
    Lacivita E; De Giorgio P; Patarnello D; Niso M; Colabufo NA; Berardi F; Perrone R; Satala G; Duszynska B; Bojarski AJ; Leopoldo M
    Exp Brain Res; 2013 Oct; 230(4):569-82. PubMed ID: 23571499
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Privileged scaffold-based design to identify a novel drug-like 5-HT
    Lacivita E; Niso M; Stama ML; Arzuaga A; Altamura C; Costa L; Desaphy JF; Ragozzino ME; Ciranna L; Leopoldo M
    Eur J Med Chem; 2020 Aug; 199():112395. PubMed ID: 32442850
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Novel highly potent serotonin 5-HT7 receptor ligands: structural modifications to improve pharmacokinetic properties.
    Lacivita E; Di Pilato P; Stama ML; Colabufo NA; Berardi F; Perrone R; De Filippis B; Laviola G; Adriani W; Niso M; Leopoldo M
    Bioorg Med Chem Lett; 2013 Nov; 23(22):6083-6. PubMed ID: 24100077
    [TBL] [Abstract][Full Text] [Related]  

  • 6. The arylpiperazine derivatives N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide and N-benzyl-4-(2-diphenyl)-1-piperazinehexanamide exert a long-lasting inhibition of human serotonin 5-HT7 receptor binding and cAMP signaling.
    Atanes P; Lacivita E; Rodríguez J; Brea J; Burgueño J; Vela JM; Cadavid MI; Loza MI; Leopoldo M; Castro M
    Pharmacol Res Perspect; 2013 Dec; 1(2):e00013. PubMed ID: 25505568
    [TBL] [Abstract][Full Text] [Related]  

  • 7. 1-Aryl-4-(4-succinimidobutyl)piperazines and their conformationally constrained analogues: synthesis, binding to serotonin (5-HT1A, 5-HT2A, 5-HT7), alpha1-adrenergic, and dopaminergic D2 receptors, and in vivo 5-HT1A functional characteristics.
    Bojarski AJ; Paluchowska MH; Duszyńska B; Kłodzińska A; Tatarczyńska E; Chojnacka-Wójcik E
    Bioorg Med Chem; 2005 Mar; 13(6):2293-303. PubMed ID: 15727878
    [TBL] [Abstract][Full Text] [Related]  

  • 8. LP-211 is a brain penetrant selective agonist for the serotonin 5-HT(7) receptor.
    Hedlund PB; Leopoldo M; Caccia S; Sarkisyan G; Fracasso C; Martelli G; Lacivita E; Berardi F; Perrone R
    Neurosci Lett; 2010 Aug; 481(1):12-6. PubMed ID: 20600619
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structure-affinity relationship study on N-(1,2,3,4-tetrahydronaphthalen-1-yl)-4-aryl-1-piperazinealkylamides, a new class of 5-hydroxytryptamine7 receptor agents.
    Leopoldo M; Berardi F; Colabufo NA; Contino M; Lacivita E; Niso M; Perrone R; Tortorella V
    J Med Chem; 2004 Dec; 47(26):6616-24. PubMed ID: 15588097
    [TBL] [Abstract][Full Text] [Related]  

  • 10. An Orally Active Phenylaminotetralin-Chemotype Serotonin 5-HT7 and 5-HT1A Receptor Partial Agonist that Corrects Motor Stereotypy in Mouse Models.
    Canal CE; Felsing DE; Liu Y; Zhu W; Wood JT; Perry CK; Vemula R; Booth RG
    ACS Chem Neurosci; 2015 Jul; 6(7):1259-70. PubMed ID: 26011730
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Serotonin (5-HT) regulates neurite outgrowth through 5-HT1A and 5-HT7 receptors in cultured hippocampal neurons.
    Rojas PS; Neira D; Muñoz M; Lavandero S; Fiedler JL
    J Neurosci Res; 2014 Aug; 92(8):1000-9. PubMed ID: 24752854
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Design, synthesis, radiolabeling and in vivo evaluation of potential positron emission tomography (PET) radioligands for brain imaging of the 5-HT₇ receptor.
    Lacivita E; Niso M; Hansen HD; Di Pilato P; Herth MM; Lehel S; Ettrup A; Montenegro L; Perrone R; Berardi F; Colabufo NA; Leopoldo M; Knudsen GM
    Bioorg Med Chem; 2014 Mar; 22(5):1736-50. PubMed ID: 24508140
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Towards the development of 5-HT₇ ligands combining serotonin-like and arylpiperazine moieties.
    Spadoni G; Bedini A; Bartolucci S; Pala D; Mor M; Riccioni T; Borsini F; Cabri W; Celona D; Marzi M; Tarzia G; Rivara S; Minetti P
    Eur J Med Chem; 2014 Jun; 80():8-35. PubMed ID: 24763360
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Aryl biphenyl-3-ylmethylpiperazines as 5-HT7 receptor antagonists.
    Kim J; Kim Y; Tae J; Yeom M; Moon B; Huang XP; Roth BL; Lee K; Rhim H; Choo IH; Chong Y; Keum G; Nam G; Choo H
    ChemMedChem; 2013 Nov; 8(11):1855-64. PubMed ID: 24039134
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Rational design in search for 5-phenylhydantoin selective 5-HT7R antagonists. Molecular modeling, synthesis and biological evaluation.
    Kucwaj-Brysz K; Warszycki D; Podlewska S; Witek J; Witek K; González Izquierdo A; Satała G; Loza MI; Lubelska A; Latacz G; Bojarski AJ; Castro M; Kieć-Kononowicz K; Handzlik J
    Eur J Med Chem; 2016 Apr; 112():258-269. PubMed ID: 26900658
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Modulatory effects following subchronic stimulation of brain 5-HT7-R system in mice and rats.
    Romano E; Ruocco LA; Nativio P; Lacivita E; Ajmone-Cat MA; Boatto G; Nieddu M; Tino A; Sadile AG; Minghetti L; Passarelli F; Leopoldo M; Laviola G; Adriani W
    Rev Neurosci; 2014; 25(3):383-400. PubMed ID: 24598832
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Stimulation of 5-HT7 receptor during adolescence determines its persistent upregulation in adult rat forebrain areas.
    Nativio P; Zoratto F; Romano E; Lacivita E; Leopoldo M; Pascale E; Passarelli F; Laviola G; Adriani W
    Synapse; 2015 Nov; 69(11):533-42. PubMed ID: 26364910
    [TBL] [Abstract][Full Text] [Related]  

  • 18. New arylpiperazinylalkyl derivatives of 8-alkoxy-purine-2,6-dione and dihydro[1,3]oxazolo[2,3-f]purinedione targeting the serotonin 5-HT1A /5-HT2A /5-HT7 and dopamine D2 receptors.
    Chłoń-Rzepa G; Zagórska A; Bucki A; Kołaczkowski M; Pawłowski M; Satała G; Bojarski AJ; Partyka A; Wesołowska A; Pękala E; Słoczyńska K
    Arch Pharm (Weinheim); 2015 Apr; 348(4):242-53. PubMed ID: 25773907
    [TBL] [Abstract][Full Text] [Related]  

  • 19. 5-HT1A-versus D2-receptor selectivity of flesinoxan and analogous N4-substituted N1-arylpiperazines.
    Kuipers W; Kruse CG; van Wijngaarden I; Standaar PJ; Tulp MT; Veldman N; Spek AL; IJzerman AP
    J Med Chem; 1997 Jan; 40(3):300-12. PubMed ID: 9022796
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Investigations on the 1-(2-biphenyl)piperazine motif: identification of new potent and selective ligands for the serotonin(7) (5-HT(7)) receptor with agonist or antagonist action in vitro or ex vivo.
    Lacivita E; Patarnello D; Stroth N; Caroli A; Niso M; Contino M; De Giorgio P; Di Pilato P; Colabufo NA; Berardi F; Perrone R; Svenningsson P; Hedlund PB; Leopoldo M
    J Med Chem; 2012 Jul; 55(14):6375-80. PubMed ID: 22738316
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 7.