170 related articles for article (PubMed ID: 27334143)
1. Involvement of AMP-activated protein kinase in mediating pyrrolo-1,5-benzoxazepine-induced apoptosis in neuroblastoma cells.
Lennon JC; Butini S; Campiani G; O'Meara A; Williams DC; Zisterer DM
Invest New Drugs; 2016 Oct; 34(5):663-76. PubMed ID: 27334143
[TBL] [Abstract][Full Text] [Related]
2. The novel pyrrolo-1,5-benzoxazepine, PBOX-6, synergistically enhances the apoptotic effects of carboplatin in drug sensitive and multidrug resistant neuroblastoma cells.
Lennon JC; Bright SA; Carroll E; Butini S; Campiani G; O'Meara A; Williams DC; Zisterer DM
Biochem Pharmacol; 2014 Feb; 87(4):611-24. PubMed ID: 24406249
[TBL] [Abstract][Full Text] [Related]
3. The novel pyrrolo-1,5-benzoxazepine, PBOX-15, synergistically enhances the apoptotic efficacy of imatinib in gastrointestinal stromal tumours; suggested mechanism of action of PBOX-15.
Kinsella P; Greene LM; Bright SA; Pollock JK; Butini S; Campiani G; Bauer S; Williams DC; Zisterer DM
Invest New Drugs; 2016 Apr; 34(2):159-67. PubMed ID: 26885657
[TBL] [Abstract][Full Text] [Related]
4. Selective induction of apoptosis by the pyrrolo-1,5-benzoxazepine 7-[[dimethylcarbamoyl]oxy]-6-(2-naphthyl)pyrrolo-[2,1-d] (1,5)-benzoxazepine (PBOX-6) in Leukemia cells occurs via the c-Jun NH2-terminal kinase-dependent phosphorylation and inactivation of Bcl-2 and Bcl-XL.
Mc Gee MM; Greene LM; Ledwidge S; Campiani G; Nacci V; Lawler M; Williams DC; Zisterer DM
J Pharmacol Exp Ther; 2004 Sep; 310(3):1084-95. PubMed ID: 15143129
[TBL] [Abstract][Full Text] [Related]
5. Sequential treatment with flavopiridol synergistically enhances pyrrolo-1,5-benzoxazepine-induced apoptosis in human chronic myeloid leukaemia cells including those resistant to imatinib treatment.
Bright SA; Campiani G; Deininger MW; Lawler M; Williams DC; Zisterer DM
Biochem Pharmacol; 2010 Jul; 80(1):31-8. PubMed ID: 20206141
[TBL] [Abstract][Full Text] [Related]
6. Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce cell cycle arrest and apoptosis in prostate cancer cells.
Nathwani SM; Cloonan SM; Stronach M; Campiani G; Lawler M; Williams DC; Zisterer DM
Oncol Rep; 2010 Dec; 24(6):1499-507. PubMed ID: 21042745
[TBL] [Abstract][Full Text] [Related]
7. Novel microtubule-targeting agents, pyrrolo-1,5-benzoxazepines, induce apoptosis in multi-drug-resistant cancer cells.
Nathwani SM; Butler S; Fayne D; McGovern NN; Sarkadi B; Meegan MJ; Lloyd DG; Campiani G; Lawler M; Williams DC; Zisterer DM
Cancer Chemother Pharmacol; 2010 Aug; 66(3):585-96. PubMed ID: 20020128
[TBL] [Abstract][Full Text] [Related]
8. The novel tubulin-targeting agent pyrrolo-1,5-benzoxazepine-15 induces apoptosis in poor prognostic subgroups of chronic lymphocytic leukemia.
McElligott AM; Maginn EN; Greene LM; McGuckin S; Hayat A; Browne PV; Butini S; Campiani G; Catherwood MA; Vandenberghe E; Williams DC; Zisterer DM; Lawler M
Cancer Res; 2009 Nov; 69(21):8366-75. PubMed ID: 19826055
[TBL] [Abstract][Full Text] [Related]
9. Identification of tubulin as the molecular target of proapoptotic pyrrolo-1,5-benzoxazepines.
Mulligan JM; Greene LM; Cloonan S; Mc Gee MM; Onnis V; Campiani G; Fattorusso C; Lawler M; Williams DC; Zisterer DM
Mol Pharmacol; 2006 Jul; 70(1):60-70. PubMed ID: 16571652
[TBL] [Abstract][Full Text] [Related]
10. Activation of the c-Jun N-terminal kinase (JNK) signaling pathway is essential during PBOX-6-induced apoptosis in chronic myelogenous leukemia (CML) cells.
Mc Gee MM; Campiani G; Ramunno A; Nacci V; Lawler M; Williams DC; Zisterer DM
J Biol Chem; 2002 May; 277(21):18383-9. PubMed ID: 11856743
[TBL] [Abstract][Full Text] [Related]
11. The pyrrolo-1,5-benzoxazepine, PBOX-6, inhibits the growth of breast cancer cells in vitro independent of estrogen receptor status and inhibits breast tumour growth in vivo.
Greene LM; Fleeton M; Mulligan J; Gowda C; Sheahan BJ; Atkins GJ; Campiani G; Nacci V; Lawler M; Williams DC; Zisterer DM
Oncol Rep; 2005 Nov; 14(5):1357-63. PubMed ID: 16211309
[TBL] [Abstract][Full Text] [Related]
12. The pyrrolo-1,5-benzoxazepine, PBOX-15, enhances TRAIL‑induced apoptosis by upregulation of DR5 and downregulation of core cell survival proteins in acute lymphoblastic leukaemia cells.
Nathwani SM; Greene LM; Butini S; Campiani G; Williams DC; Samali A; Szegezdi E; Zisterer DM
Int J Oncol; 2016 Jul; 49(1):74-88. PubMed ID: 27176505
[TBL] [Abstract][Full Text] [Related]
13. Activation of AMP-activated protein kinase is involved in vincristine-induced cell apoptosis in B16 melanoma cell.
Chen MB; Shen WX; Yang Y; Wu XY; Gu JH; Lu PH
J Cell Physiol; 2011 Jul; 226(7):1915-25. PubMed ID: 21506122
[TBL] [Abstract][Full Text] [Related]
14. The novel pyrrolo-1,5-benzoxazepine, PBOX-21, potentiates the apoptotic efficacy of STI571 (imatinib mesylate) in human chronic myeloid leukaemia cells.
Bright SA; Greene LM; Greene TF; Campiani G; Butini S; Brindisi M; Lawler M; Meegan MJ; Williams DC; Zisterer DM
Biochem Pharmacol; 2009 Feb; 77(3):310-21. PubMed ID: 19014913
[TBL] [Abstract][Full Text] [Related]
15. STI-571 (imatinib mesylate) enhances the apoptotic efficacy of pyrrolo-1,5-benzoxazepine-6, a novel microtubule-targeting agent, in both STI-571-sensitive and -resistant Bcr-Abl-positive human chronic myeloid leukemia cells.
Greene LM; Kelly L; Onnis V; Campiani G; Lawler M; Williams DC; Zisterer DM
J Pharmacol Exp Ther; 2007 Apr; 321(1):288-97. PubMed ID: 17202400
[TBL] [Abstract][Full Text] [Related]
16. Pyrrolo-1,5-benzoxazepines induce apoptosis in chronic myelogenous leukemia (CML) cells by bypassing the apoptotic suppressor bcr-abl.
Mc Gee MM; Campiani G; Ramunno A; Fattorusso C; Nacci V; Lawler M; Williams DC; Zisterer DM
J Pharmacol Exp Ther; 2001 Jan; 296(1):31-40. PubMed ID: 11123359
[TBL] [Abstract][Full Text] [Related]
17. Novel pyrrolo-1,5-benzoxazepine compounds display significant activity against resistant chronic myeloid leukaemia cells in vitro, in ex vivo patient samples and in vivo.
Bright SA; McElligott AM; O'Connell JW; O'Connor L; Carroll P; Campiani G; Deininger MW; Conneally E; Lawler M; Williams DC; Zisterer DM
Br J Cancer; 2010 May; 102(10):1474-82. PubMed ID: 20407438
[TBL] [Abstract][Full Text] [Related]
18. Antitumor effect of pyrrolo-1,5-benzoxazepine-15 and its synergistic effect with Oxaliplatin and 5-FU in colorectal cancer cells.
Fiore D; Proto MC; Pisanti S; Picardi P; Pagano Zottola AC; Butini S; Gemma S; Casagni A; Laezza C; Vitale M; Ligresti A; Di Marzo V; Zisterer DM; Nathwani S; Williams DC; Campiani G; Gazzerro P; Bifulco M
Cancer Biol Ther; 2016 Aug; 17(8):849-58. PubMed ID: 26392056
[TBL] [Abstract][Full Text] [Related]
19. PBOX-15, a novel microtubule targeting agent, induces apoptosis, upregulates death receptors, and potentiates TRAIL-mediated apoptosis in multiple myeloma cells.
Maginn EN; Browne PV; Hayden P; Vandenberghe E; MacDonagh B; Evans P; Goodyer M; Tewari P; Campiani G; Butini S; Williams DC; Zisterer DM; Lawler MP; McElligott AM
Br J Cancer; 2011 Jan; 104(2):281-9. PubMed ID: 21179037
[TBL] [Abstract][Full Text] [Related]
20. Pyrrolo-1,5-benzoxazepines induce apoptosis in HL-60, Jurkat, and Hut-78 cells: a new class of apoptotic agents.
Zisterer DM; Campiani G; Nacci V; Williams DC
J Pharmacol Exp Ther; 2000 Apr; 293(1):48-59. PubMed ID: 10734152
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
