152 related articles for article (PubMed ID: 27339735)
1. Intestinally-targeted TGR5 agonists equipped with quaternary ammonium have an improved hypoglycemic effect and reduced gallbladder filling effect.
Cao H; Chen ZX; Wang K; Ning MM; Zou QA; Feng Y; Ye YL; Leng Y; Shen JH
Sci Rep; 2016 Jun; 6():28676. PubMed ID: 27339735
[TBL] [Abstract][Full Text] [Related]
2. OL3, a novel low-absorbed TGR5 agonist with reduced side effects, lowered blood glucose via dual actions on TGR5 activation and DPP-4 inhibition.
Ma SY; Ning MM; Zou QA; Feng Y; Ye YL; Shen JH; Leng Y
Acta Pharmacol Sin; 2016 Sep; 37(10):1359-1369. PubMed ID: 27264313
[TBL] [Abstract][Full Text] [Related]
3. Novel Small Molecule Agonist of TGR5 Possesses Anti-Diabetic Effects but Causes Gallbladder Filling in Mice.
Briere DA; Ruan X; Cheng CC; Siesky AM; Fitch TE; Dominguez C; Sanfeliciano SG; Montero C; Suen CS; Xu Y; Coskun T; Michael MD
PLoS One; 2015; 10(8):e0136873. PubMed ID: 26312995
[TBL] [Abstract][Full Text] [Related]
4. Intestinal TGR5 agonism improves hepatic steatosis and insulin sensitivity in Western diet-fed mice.
Finn PD; Rodriguez D; Kohler J; Jiang Z; Wan S; Blanco E; King AJ; Chen T; Bell N; Dragoli D; Jacobs JW; Jain R; Leadbetter M; Siegel M; Carreras CW; Koo-McCoy S; Shaw K; Le C; Vanegas S; Hsu IH; Kozuka K; Okamoto K; Caldwell JS; Lewis JG
Am J Physiol Gastrointest Liver Physiol; 2019 Mar; 316(3):G412-G424. PubMed ID: 30605011
[TBL] [Abstract][Full Text] [Related]
5. A Novel TGR5 Activator WB403 Promotes GLP-1 Secretion and Preserves Pancreatic β-Cells in Type 2 Diabetic Mice.
Zheng C; Zhou W; Wang T; You P; Zhao Y; Yang Y; Wang X; Luo J; Chen Y; Liu M; Chen H
PLoS One; 2015; 10(7):e0134051. PubMed ID: 26208278
[TBL] [Abstract][Full Text] [Related]
6. TGR5 agonist ameliorates insulin resistance in the skeletal muscles and improves glucose homeostasis in diabetic mice.
Huang S; Ma S; Ning M; Yang W; Ye Y; Zhang L; Shen J; Leng Y
Metabolism; 2019 Oct; 99():45-56. PubMed ID: 31295453
[TBL] [Abstract][Full Text] [Related]
7. Glucagon-like peptide-2 promotes gallbladder refilling via a TGR5-independent, GLP-2R-dependent pathway.
Yusta B; Matthews D; Flock GB; Ussher JR; Lavoie B; Mawe GM; Drucker DJ
Mol Metab; 2017 Jun; 6(6):503-511. PubMed ID: 28580281
[TBL] [Abstract][Full Text] [Related]
8. Pharmacological activation of TGR5 promotes intestinal growth via a GLP-2-dependent pathway in mice.
Hunt JE; Billeschou A; Windeløv JA; Hartmann B; Ullmer C; Holst JJ; Kissow H
Am J Physiol Gastrointest Liver Physiol; 2020 May; 318(5):G980-G987. PubMed ID: 32308039
[TBL] [Abstract][Full Text] [Related]
9. Topical Intestinal Aminoimidazole Agonists of G-Protein-Coupled Bile Acid Receptor 1 Promote Glucagon Like Peptide-1 Secretion and Improve Glucose Tolerance.
Lasalle M; Hoguet V; Hennuyer N; Leroux F; Piveteau C; Belloy L; Lestavel S; Vallez E; Dorchies E; Duplan I; Sevin E; Culot M; Gosselet F; Boulahjar R; Herledan A; Staels B; Deprez B; Tailleux A; Charton J
J Med Chem; 2017 May; 60(10):4185-4211. PubMed ID: 28414465
[TBL] [Abstract][Full Text] [Related]
10. Design, synthesis, and antidiabetic activity of 4-phenoxynicotinamide and 4-phenoxypyrimidine-5-carboxamide derivatives as potent and orally efficacious TGR5 agonists.
Duan H; Ning M; Chen X; Zou Q; Zhang L; Feng Y; Zhang L; Leng Y; Shen J
J Med Chem; 2012 Dec; 55(23):10475-89. PubMed ID: 23148522
[TBL] [Abstract][Full Text] [Related]
11. Discovery of Intestinal Targeted TGR5 Agonists for the Treatment of Type 2 Diabetes.
Duan H; Ning M; Zou Q; Ye Y; Feng Y; Zhang L; Leng Y; Shen J
J Med Chem; 2015 Apr; 58(8):3315-28. PubMed ID: 25710631
[TBL] [Abstract][Full Text] [Related]
12. Identification of Betulinic Acid Derivatives as Potent TGR5 Agonists with Antidiabetic Effects via Humanized TGR5
Yun Y; Zhang C; Guo S; Liang X; Lan Y; Wang M; Zhuo N; Yin J; Liu H; Gu M; Li J; Xie X; Nan F
J Med Chem; 2021 Aug; 64(16):12181-12199. PubMed ID: 34406006
[TBL] [Abstract][Full Text] [Related]
13. Design of G-protein-coupled bile acid receptor 1 (GPBAR1, TGR5) soft drugs with reduced gallbladder-filling effects.
Han F; Ning M; Cao H; Ye Y; Feng Y; Leng Y; Shen J
Eur J Med Chem; 2020 Oct; 203():112619. PubMed ID: 32682201
[TBL] [Abstract][Full Text] [Related]
14. Ginsenoside metabolite compound K stimulates glucagon-like peptide-1 secretion in NCI-H716 cells via bile acid receptor activation.
Kim K; Park M; Lee YM; Rhyu MR; Kim HY
Arch Pharm Res; 2014; 37(9):1193-200. PubMed ID: 24590628
[TBL] [Abstract][Full Text] [Related]
15. Evaluation of novel TGR5 agonist in combination with Sitagliptin for possible treatment of type 2 diabetes.
Agarwal S; Sasane S; Kumar J; Deshmukh P; Bhayani H; Giri P; Giri S; Soman S; Kulkarni N; Jain M
Bioorg Med Chem Lett; 2018 Jun; 28(10):1849-1852. PubMed ID: 29655980
[TBL] [Abstract][Full Text] [Related]
16. Design of Gut-Restricted Thiazolidine Agonists of G Protein-Coupled Bile Acid Receptor 1 (GPBAR1, TGR5).
Chen T; Reich NW; Bell N; Finn PD; Rodriguez D; Kohler J; Kozuka K; He L; Spencer AG; Charmot D; Navre M; Carreras CW; Koo-McCoy S; Tabora J; Caldwell JS; Jacobs JW; Lewis JG
J Med Chem; 2018 Sep; 61(17):7589-7613. PubMed ID: 30141927
[TBL] [Abstract][Full Text] [Related]
17. Discovery of betulinic acid derivatives as gut-restricted TGR5 agonists: Balancing the potency and physicochemical properties.
Zhuo N; Yun Y; Zhang C; Guo S; Yin J; Zhao T; Ge X; Gu M; Xie X; Nan F
Bioorg Chem; 2024 Mar; 144():107132. PubMed ID: 38241768
[TBL] [Abstract][Full Text] [Related]
18. TGR5-mediated bile acid sensing controls glucose homeostasis.
Thomas C; Gioiello A; Noriega L; Strehle A; Oury J; Rizzo G; Macchiarulo A; Yamamoto H; Mataki C; Pruzanski M; Pellicciari R; Auwerx J; Schoonjans K
Cell Metab; 2009 Sep; 10(3):167-77. PubMed ID: 19723493
[TBL] [Abstract][Full Text] [Related]
19. Discovery of trifluoromethyl(pyrimidin-2-yl)azetidine-2-carboxamides as potent, orally bioavailable TGR5 (GPBAR1) agonists: structure-activity relationships, lead optimization, and chronic in vivo efficacy.
Phillips DP; Gao W; Yang Y; Zhang G; Lerario IK; Lau TL; Jiang J; Wang X; Nguyen DG; Bhat BG; Trotter C; Sullivan H; Welzel G; Landry J; Chen Y; Joseph SB; Li C; Gordon WP; Richmond W; Johnson K; Bretz A; Bursulaya B; Pan S; McNamara P; Seidel HM
J Med Chem; 2014 Apr; 57(8):3263-82. PubMed ID: 24666203
[TBL] [Abstract][Full Text] [Related]
20. The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling.
Li T; Holmstrom SR; Kir S; Umetani M; Schmidt DR; Kliewer SA; Mangelsdorf DJ
Mol Endocrinol; 2011 Jun; 25(6):1066-71. PubMed ID: 21454404
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]