BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

694 related articles for article (PubMed ID: 27341800)

  • 21. Multi-modal proteomic characterization of lysosomal function and proteostasis in progranulin-deficient neurons.
    Hasan S; Fernandopulle MS; Humble SW; Frankenfield AM; Li H; Prestil R; Johnson KR; Ryan BJ; Wade-Martins R; Ward ME; Hao L
    Mol Neurodegener; 2023 Nov; 18(1):87. PubMed ID: 37974165
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Lysosomal processing of progranulin.
    Zhou X; Paushter DH; Feng T; Sun L; Reinheckel T; Hu F
    Mol Neurodegener; 2017 Aug; 12(1):62. PubMed ID: 28835281
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Progranulin regulates neuronal outgrowth independent of sortilin.
    Gass J; Lee WC; Cook C; Finch N; Stetler C; Jansen-West K; Lewis J; Link CD; Rademakers R; Nykjær A; Petrucelli L
    Mol Neurodegener; 2012 Jul; 7():33. PubMed ID: 22781549
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Peripheral expression of brain-penetrant progranulin rescues pathologies in mouse models of frontotemporal lobar degeneration.
    Reich M; Simon MJ; Polke B; Paris I; Werner G; Schrader C; Spieth L; Davis SS; Robinson S; de Melo GL; Schlaphoff L; Buschmann K; Berghoff S; Logan T; Nuscher B; de Weerd L; Edbauer D; Simons M; Suh JH; Sandmann T; Kariolis MS; DeVos SL; Lewcock JW; Paquet D; Capell A; Di Paolo G; Haass C
    Sci Transl Med; 2024 Jun; 16(750):eadj7308. PubMed ID: 38838131
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency.
    Arrant AE; Nicholson AM; Zhou X; Rademakers R; Roberson ED
    Mol Neurodegener; 2018 Jun; 13(1):32. PubMed ID: 29929528
    [TBL] [Abstract][Full Text] [Related]  

  • 26. The Receptor-interacting Serine/Threonine Protein Kinase 1 (RIPK1) Regulates Progranulin Levels.
    Mason AR; Elia LP; Finkbeiner S
    J Biol Chem; 2017 Feb; 292(8):3262-3272. PubMed ID: 28069809
    [TBL] [Abstract][Full Text] [Related]  

  • 27. A Novel Splice-Acceptor Site Mutation in GRN (c.709-2 A>T) Causes Frontotemporal Dementia Spectrum in a Large Family from Southern Italy.
    Sassi C; Capozzo R; Gibbs R; Crews C; Zecca C; Arcuti S; Copetti M; Barulli MR; Brescia V; Singleton AB; Logroscino G
    J Alzheimers Dis; 2016 May; 53(2):475-85. PubMed ID: 27258413
    [TBL] [Abstract][Full Text] [Related]  

  • 28. Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.
    Minami SS; Min SW; Krabbe G; Wang C; Zhou Y; Asgarov R; Li Y; Martens LH; Elia LP; Ward ME; Mucke L; Farese RV; Gan L
    Nat Med; 2014 Oct; 20(10):1157-64. PubMed ID: 25261995
    [TBL] [Abstract][Full Text] [Related]  

  • 29. Selectivity and Kinetic Requirements of HDAC Inhibitors as Progranulin Enhancers for Treating Frontotemporal Dementia.
    She A; Kurtser I; Reis SA; Hennig K; Lai J; Lang A; Zhao WN; Mazitschek R; Dickerson BC; Herz J; Haggarty SJ
    Cell Chem Biol; 2017 Jul; 24(7):892-906.e5. PubMed ID: 28712747
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Progranulin regulates lysosomal function and biogenesis through acidification of lysosomes.
    Tanaka Y; Suzuki G; Matsuwaki T; Hosokawa M; Serrano G; Beach TG; Yamanouchi K; Hasegawa M; Nishihara M
    Hum Mol Genet; 2017 Mar; 26(5):969-988. PubMed ID: 28073925
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Progranulin deficiency leads to reduced glucocerebrosidase activity.
    Zhou X; Paushter DH; Pagan MD; Kim D; Nunez Santos M; Lieberman RL; Overkleeft HS; Sun Y; Smolka MB; Hu F
    PLoS One; 2019; 14(7):e0212382. PubMed ID: 31291241
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase.
    Capell A; Liebscher S; Fellerer K; Brouwers N; Willem M; Lammich S; Gijselinck I; Bittner T; Carlson AM; Sasse F; Kunze B; Steinmetz H; Jansen R; Dormann D; Sleegers K; Cruts M; Herms J; Van Broeckhoven C; Haass C
    J Neurosci; 2011 Feb; 31(5):1885-94. PubMed ID: 21289198
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Prosaposin is a regulator of progranulin levels and oligomerization.
    Nicholson AM; Finch NA; Almeida M; Perkerson RB; van Blitterswijk M; Wojtas A; Cenik B; Rotondo S; Inskeep V; Almasy L; Dyer T; Peralta J; Jun G; Wood AR; Frayling TM; Fuchsberger C; Fowler S; Teslovich TM; Manning AK; Kumar S; Curran J; Lehman D; Abecasis G; Duggirala R; Pottier C; Zahir HA; Crook JE; Karydas A; Mitic L; Sun Y; Dickson DW; Bu G; Herz J; Yu G; Miller BL; Ferguson S; Petersen RC; Graff-Radford N; Blangero J; Rademakers R
    Nat Commun; 2016 Jun; 7():11992. PubMed ID: 27356620
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Impaired β-glucocerebrosidase activity and processing in frontotemporal dementia due to progranulin mutations.
    Arrant AE; Roth JR; Boyle NR; Kashyap SN; Hoffmann MQ; Murchison CF; Ramos EM; Nana AL; Spina S; Grinberg LT; Miller BL; Seeley WW; Roberson ED
    Acta Neuropathol Commun; 2019 Dec; 7(1):218. PubMed ID: 31870439
    [TBL] [Abstract][Full Text] [Related]  

  • 35. Processing of progranulin into granulins involves multiple lysosomal proteases and is affected in frontotemporal lobar degeneration.
    Mohan S; Sampognaro PJ; Argouarch AR; Maynard JC; Welch M; Patwardhan A; Courtney EC; Zhang J; Mason A; Li KH; Huang EJ; Seeley WW; Miller BL; Burlingame A; Jacobson MP; Kao AW
    Mol Neurodegener; 2021 Aug; 16(1):51. PubMed ID: 34344440
    [TBL] [Abstract][Full Text] [Related]  

  • 36. TMEM106B p.T185S regulates TMEM106B protein levels: implications for frontotemporal dementia.
    Nicholson AM; Finch NA; Wojtas A; Baker MC; Perkerson RB; Castanedes-Casey M; Rousseau L; Benussi L; Binetti G; Ghidoni R; Hsiung GY; Mackenzie IR; Finger E; Boeve BF; Ertekin-Taner N; Graff-Radford NR; Dickson DW; Rademakers R
    J Neurochem; 2013 Sep; 126(6):781-91. PubMed ID: 23742080
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Lysosomal functions of progranulin and implications for treatment of frontotemporal dementia.
    Simon MJ; Logan T; DeVos SL; Di Paolo G
    Trends Cell Biol; 2023 Apr; 33(4):324-339. PubMed ID: 36244875
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Reduction of microglial progranulin does not exacerbate pathology or behavioral deficits in neuronal progranulin-insufficient mice.
    Arrant AE; Filiano AJ; Patel AR; Hoffmann MQ; Boyle NR; Kashyap SN; Onyilo VC; Young AH; Roberson ED
    Neurobiol Dis; 2019 Apr; 124():152-162. PubMed ID: 30448285
    [TBL] [Abstract][Full Text] [Related]  

  • 39. GRN-/- iPSC-derived cortical neurons recapitulate the pathological findings of both frontotemporal lobar degeneration and neuronal ceroidolipofuscinosis.
    Bossolasco P; Cimini S; Maderna E; Bardelli D; Canafoglia L; Cavallaro T; Ricci M; Silani V; Marucci G; Rossi G
    Neurobiol Dis; 2022 Dec; 175():105891. PubMed ID: 36220610
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.
    Logan T; Simon MJ; Rana A; Cherf GM; Srivastava A; Davis SS; Low RLY; Chiu CL; Fang M; Huang F; Bhalla A; Llapashtica C; Prorok R; Pizzo ME; Calvert MEK; Sun EW; Hsiao-Nakamoto J; Rajendra Y; Lexa KW; Srivastava DB; van Lengerich B; Wang J; Robles-Colmenares Y; Kim DJ; Duque J; Lenser M; Earr TK; Nguyen H; Chau R; Tsogtbaatar B; Ravi R; Skuja LL; Solanoy H; Rosen HJ; Boeve BF; Boxer AL; Heuer HW; Dennis MS; Kariolis MS; Monroe KM; Przybyla L; Sanchez PE; Meisner R; Diaz D; Henne KR; Watts RJ; Henry AG; Gunasekaran K; Astarita G; Suh JH; Lewcock JW; DeVos SL; Di Paolo G
    Cell; 2021 Sep; 184(18):4651-4668.e25. PubMed ID: 34450028
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 35.