These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.
1231 related articles for article (PubMed ID: 27362227)
1. Allosteric inhibition of SHP2 phosphatase inhibits cancers driven by receptor tyrosine kinases. Chen YN; LaMarche MJ; Chan HM; Fekkes P; Garcia-Fortanet J; Acker MG; Antonakos B; Chen CH; Chen Z; Cooke VG; Dobson JR; Deng Z; Fei F; Firestone B; Fodor M; Fridrich C; Gao H; Grunenfelder D; Hao HX; Jacob J; Ho S; Hsiao K; Kang ZB; Karki R; Kato M; Larrow J; La Bonte LR; Lenoir F; Liu G; Liu S; Majumdar D; Meyer MJ; Palermo M; Perez L; Pu M; Price E; Quinn C; Shakya S; Shultz MD; Slisz J; Venkatesan K; Wang P; Warmuth M; Williams S; Yang G; Yuan J; Zhang JH; Zhu P; Ramsey T; Keen NJ; Sellers WR; Stams T; Fortin PD Nature; 2016 Jul; 535(7610):148-52. PubMed ID: 27362227 [TBL] [Abstract][Full Text] [Related]
2. Allosteric Inhibitors of SHP2 with Therapeutic Potential for Cancer Treatment. Xie J; Si X; Gu S; Wang M; Shen J; Li H; Shen J; Li D; Fang Y; Liu C; Zhu J J Med Chem; 2017 Dec; 60(24):10205-10219. PubMed ID: 29155585 [TBL] [Abstract][Full Text] [Related]
3. Allosteric Inhibition of SHP2: Identification of a Potent, Selective, and Orally Efficacious Phosphatase Inhibitor. Garcia Fortanet J; Chen CH; Chen YN; Chen Z; Deng Z; Firestone B; Fekkes P; Fodor M; Fortin PD; Fridrich C; Grunenfelder D; Ho S; Kang ZB; Karki R; Kato M; Keen N; LaBonte LR; Larrow J; Lenoir F; Liu G; Liu S; Lombardo F; Majumdar D; Meyer MJ; Palermo M; Perez L; Pu M; Ramsey T; Sellers WR; Shultz MD; Stams T; Towler C; Wang P; Williams SL; Zhang JH; LaMarche MJ J Med Chem; 2016 Sep; 59(17):7773-82. PubMed ID: 27347692 [TBL] [Abstract][Full Text] [Related]
4. Dual Allosteric Inhibition of SHP2 Phosphatase. Fodor M; Price E; Wang P; Lu H; Argintaru A; Chen Z; Glick M; Hao HX; Kato M; Koenig R; LaRochelle JR; Liu G; McNeill E; Majumdar D; Nishiguchi GA; Perez LB; Paris G; Quinn CM; Ramsey T; Sendzik M; Shultz MD; Williams SL; Stams T; Blacklow SC; Acker MG; LaMarche MJ ACS Chem Biol; 2018 Mar; 13(3):647-656. PubMed ID: 29304282 [TBL] [Abstract][Full Text] [Related]
5. RAS nucleotide cycling underlies the SHP2 phosphatase dependence of mutant BRAF-, NF1- and RAS-driven cancers. Nichols RJ; Haderk F; Stahlhut C; Schulze CJ; Hemmati G; Wildes D; Tzitzilonis C; Mordec K; Marquez A; Romero J; Hsieh T; Zaman A; Olivas V; McCoach C; Blakely CM; Wang Z; Kiss G; Koltun ES; Gill AL; Singh M; Goldsmith MA; Smith JAM; Bivona TG Nat Cell Biol; 2018 Sep; 20(9):1064-1073. PubMed ID: 30104724 [TBL] [Abstract][Full Text] [Related]
6. Canine histiocytic sarcoma cell lines with SHP2 p.Glu76Gln or p.Glu76Ala mutations are sensitive to allosteric SHP2 inhibitor SHP099. Tani H; Kurita S; Miyamoto R; Ochiai K; Tamura K; Bonkobara M Vet Comp Oncol; 2020 Jun; 18(2):161-168. PubMed ID: 31339650 [TBL] [Abstract][Full Text] [Related]
7. SHP2 Drives Adaptive Resistance to ERK Signaling Inhibition in Molecularly Defined Subsets of ERK-Dependent Tumors. Ahmed TA; Adamopoulos C; Karoulia Z; Wu X; Sachidanandam R; Aaronson SA; Poulikakos PI Cell Rep; 2019 Jan; 26(1):65-78.e5. PubMed ID: 30605687 [TBL] [Abstract][Full Text] [Related]
8. PCC0208023, a potent SHP2 allosteric inhibitor, imparts an antitumor effect against KRAS mutant colorectal cancer. Chen X; Zou F; Hu Z; Du G; Yu P; Wang W; Wang H; Ye L; Tian J Toxicol Appl Pharmacol; 2020 Jul; 398():115019. PubMed ID: 32335126 [TBL] [Abstract][Full Text] [Related]
9. Structural reorganization of SHP2 by oncogenic mutations and implications for oncoprotein resistance to allosteric inhibition. LaRochelle JR; Fodor M; Vemulapalli V; Mohseni M; Wang P; Stams T; LaMarche MJ; Chopra R; Acker MG; Blacklow SC Nat Commun; 2018 Oct; 9(1):4508. PubMed ID: 30375388 [TBL] [Abstract][Full Text] [Related]
10. Valencia-Sama I; Ladumor Y; Kee L; Adderley T; Christopher G; Robinson CM; Kano Y; Ohh M; Irwin MS Cancer Res; 2020 Aug; 80(16):3413-3423. PubMed ID: 32586982 [TBL] [Abstract][Full Text] [Related]
11. Phosphorylation of SHP2 at Tyr62 Enables Acquired Resistance to SHP2 Allosteric Inhibitors in FLT3-ITD-Driven AML. Pfeiffer A; Franciosa G; Locard-Paulet M; Piga I; Reckzeh K; Vemulapalli V; Blacklow SC; Theilgaard-Mönch K; Jensen LJ; Olsen JV Cancer Res; 2022 Jun; 82(11):2141-2155. PubMed ID: 35311954 [TBL] [Abstract][Full Text] [Related]
12. SHP2 inhibition restores sensitivity in ALK-rearranged non-small-cell lung cancer resistant to ALK inhibitors. Dardaei L; Wang HQ; Singh M; Fordjour P; Shaw KX; Yoda S; Kerr G; Yu K; Liang J; Cao Y; Chen Y; Lawrence MS; Langenbucher A; Gainor JF; Friboulet L; Dagogo-Jack I; Myers DT; Labrot E; Ruddy D; Parks M; Lee D; DiCecca RH; Moody S; Hao H; Mohseni M; LaMarche M; Williams J; Hoffmaster K; Caponigro G; Shaw AT; Hata AN; Benes CH; Li F; Engelman JA Nat Med; 2018 May; 24(4):512-517. PubMed ID: 29505033 [TBL] [Abstract][Full Text] [Related]
13. Scaffold-based novel SHP2 allosteric inhibitors design using Receptor-Ligand pharmacophore model, virtual screening and molecular dynamics. Jin WY; Ma Y; Li WY; Li HL; Wang RL Comput Biol Chem; 2018 Apr; 73():179-188. PubMed ID: 29494926 [TBL] [Abstract][Full Text] [Related]
14. Identification of an allosteric benzothiazolopyrimidone inhibitor of the oncogenic protein tyrosine phosphatase SHP2. LaRochelle JR; Fodor M; Ellegast JM; Liu X; Vemulapalli V; Mohseni M; Stams T; Buhrlage SJ; Stegmaier K; LaMarche MJ; Acker MG; Blacklow SC Bioorg Med Chem; 2017 Dec; 25(24):6479-6485. PubMed ID: 29089257 [TBL] [Abstract][Full Text] [Related]
15. Exploring the dynamic mechanism of allosteric drug SHP099 inhibiting SHP2 Du S; Lu XH; Li WY; Li LP; Ma YC; Zhou L; Wu JW; Ma Y; Wang RL Mol Divers; 2021 Aug; 25(3):1873-1887. PubMed ID: 33392964 [TBL] [Abstract][Full Text] [Related]
16. Inhibition of SHP2 as an approach to block RAS-driven cancers. Chou YT; Bivona TG Adv Cancer Res; 2022; 153():205-236. PubMed ID: 35101231 [TBL] [Abstract][Full Text] [Related]
17. Off-target autophagy inhibition by SHP2 allosteric inhibitors contributes to their antitumor activity in RAS-driven cancers. Miao Y; Bai Y; Miao J; Murray AA; Lin J; Dong J; Qu Z; Zhang RY; Nguyen QD; Wang S; Yu J; Nguele Meke F; Zhang ZY J Clin Invest; 2024 Jun; 134(15):. PubMed ID: 38842946 [TBL] [Abstract][Full Text] [Related]
18. Mutant KRAS-driven cancers depend on PTPN11/SHP2 phosphatase. Ruess DA; Heynen GJ; Ciecielski KJ; Ai J; Berninger A; Kabacaoglu D; Görgülü K; Dantes Z; Wörmann SM; Diakopoulos KN; Karpathaki AF; Kowalska M; Kaya-Aksoy E; Song L; van der Laan EAZ; López-Alberca MP; Nazaré M; Reichert M; Saur D; Erkan MM; Hopt UT; Sainz B; Birchmeier W; Schmid RM; Lesina M; Algül H Nat Med; 2018 Jul; 24(7):954-960. PubMed ID: 29808009 [TBL] [Abstract][Full Text] [Related]
19. SHP2 Inhibition Enhances the Effects of Tyrosine Kinase Inhibitors in Preclinical Models of Treatment-naïve Kano H; Ichihara E; Watanabe H; Nishii K; Ando C; Nakasuka T; Ninomiya K; Kato Y; Kubo T; Rai K; Ohashi K; Hotta K; Tabata M; Maeda Y; Kiura K Mol Cancer Ther; 2021 Sep; 20(9):1653-1662. PubMed ID: 34158345 [TBL] [Abstract][Full Text] [Related]
20. Combinations with Allosteric SHP2 Inhibitor TNO155 to Block Receptor Tyrosine Kinase Signaling. Liu C; Lu H; Wang H; Loo A; Zhang X; Yang G; Kowal C; Delach S; Wang Y; Goldoni S; Hastings WD; Wong K; Gao H; Meyer MJ; Moody SE; LaMarche MJ; Engelman JA; Williams JA; Hammerman PS; Abrams TJ; Mohseni M; Caponigro G; Hao HX Clin Cancer Res; 2021 Jan; 27(1):342-354. PubMed ID: 33046519 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]