BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

378 related articles for article (PubMed ID: 27374062)

  • 21. Synthesis, Biological Evaluation, and Computer-Aided Drug Designing of New Derivatives of Hyperactive Suberoylanilide Hydroxamic Acid Histone Deacetylase Inhibitors.
    Zhang S; Huang W; Li X; Yang Z; Feng B
    Chem Biol Drug Des; 2015 Oct; 86(4):795-804. PubMed ID: 25763653
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Development of tetrahydroisoquinoline-based hydroxamic acid derivatives: potent histone deacetylase inhibitors with marked in vitro and in vivo antitumor activities.
    Zhang Y; Feng J; Jia Y; Wang X; Zhang L; Liu C; Fang H; Xu W
    J Med Chem; 2011 Apr; 54(8):2823-38. PubMed ID: 21476600
    [TBL] [Abstract][Full Text] [Related]  

  • 23. Structures of metal-substituted human histone deacetylase 8 provide mechanistic inferences on biological function .
    Dowling DP; Gattis SG; Fierke CA; Christianson DW
    Biochemistry; 2010 Jun; 49(24):5048-56. PubMed ID: 20545365
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Variable active site loop conformations accommodate the binding of macrocyclic largazole analogues to HDAC8.
    Decroos C; Clausen DJ; Haines BE; Wiest O; Williams RM; Christianson DW
    Biochemistry; 2015 Mar; 54(12):2126-35. PubMed ID: 25793284
    [TBL] [Abstract][Full Text] [Related]  

  • 25. A novel suberoylanilide hydroxamic acid histone deacetylase inhibitor derivative, N25, exhibiting improved antitumor activity in both human U251 and H460 cells.
    Zhang S; Huang WB; Wu L; Wang LY; Ye LB; Feng BH
    Asian Pac J Cancer Prev; 2014; 15(10):4331-8. PubMed ID: 24935393
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Benzothiazole-containing hydroxamic acids as histone deacetylase inhibitors and antitumor agents.
    Oanh DT; Hai HV; Park SH; Kim HJ; Han BW; Kim HS; Hong JT; Han SB; Hue VT; Nam NH
    Bioorg Med Chem Lett; 2011 Dec; 21(24):7509-12. PubMed ID: 22036991
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Binding of the Microbial Cyclic Tetrapeptide Trapoxin A to the Class I Histone Deacetylase HDAC8.
    Porter NJ; Christianson DW
    ACS Chem Biol; 2017 Sep; 12(9):2281-2286. PubMed ID: 28846375
    [TBL] [Abstract][Full Text] [Related]  

  • 28. On the inhibition of histone deacetylase 8.
    Estiu G; West N; Mazitschek R; Greenberg E; Bradner JE; Wiest O
    Bioorg Med Chem; 2010 Jun; 18(11):4103-10. PubMed ID: 20472442
    [TBL] [Abstract][Full Text] [Related]  

  • 29. SAHA Capture Compound--a novel tool for the profiling of histone deacetylases and the identification of additional vorinostat binders.
    Fischer JJ; Michaelis S; Schrey AK; Diehl A; Graebner OY; Ungewiss J; Horzowski S; Glinski M; Kroll F; Dreger M; Koester H
    Proteomics; 2011 Oct; 11(20):4096-104. PubMed ID: 21898820
    [TBL] [Abstract][Full Text] [Related]  

  • 30. Histone deacetylase inhibitors: a review on class-I specific inhibition.
    Behera J; Jayaprakash V; Sinha BN
    Mini Rev Med Chem; 2015; 15(9):731-50. PubMed ID: 25994050
    [TBL] [Abstract][Full Text] [Related]  

  • 31. Synthesis and evaluation of aliphatic-chain hydroxamates capped with osthole derivatives as histone deacetylase inhibitors.
    Huang WJ; Chen CC; Chao SW; Yu CC; Yang CY; Guh JH; Lin YC; Kuo CI; Yang P; Chang CI
    Eur J Med Chem; 2011 Sep; 46(9):4042-9. PubMed ID: 21712146
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Structures of a histone deacetylase homologue bound to the TSA and SAHA inhibitors.
    Finnin MS; Donigian JR; Cohen A; Richon VM; Rifkind RA; Marks PA; Breslow R; Pavletich NP
    Nature; 1999 Sep; 401(6749):188-93. PubMed ID: 10490031
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Biological and biophysical properties of the histone deacetylase inhibitor suberoylanilide hydroxamic acid are affected by the presence of short alkyl groups on the phenyl ring.
    Oger F; Lecorgne A; Sala E; Nardese V; Demay F; Chevance S; Desravines DC; Aleksandrova N; Le Guével R; Lorenzi S; Beccari AR; Barath P; Hart DJ; Bondon A; Carettoni D; Simonneaux G; Salbert G
    J Med Chem; 2010 Mar; 53(5):1937-50. PubMed ID: 20143840
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Design, synthesis and biological evaluation of tyrosine-based hydroxamic acid analogs as novel histone deacetylases (HDACs) inhibitors.
    Zhang Y; Feng J; Liu C; Fang H; Xu W
    Bioorg Med Chem; 2011 Aug; 19(15):4437-44. PubMed ID: 21733698
    [TBL] [Abstract][Full Text] [Related]  

  • 35. MYC directs transcription of MCL1 and eIF4E genes to control sensitivity of gastric cancer cells toward HDAC inhibitors.
    Labisso WL; Wirth M; Stojanovic N; Stauber RH; Schnieke A; Schmid RM; Krämer OH; Saur D; Schneider G
    Cell Cycle; 2012 Apr; 11(8):1593-602. PubMed ID: 22456335
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Design, synthesis, and biological activity of NCC149 derivatives as histone deacetylase 8-selective inhibitors.
    Suzuki T; Muto N; Bando M; Itoh Y; Masaki A; Ri M; Ota Y; Nakagawa H; Iida S; Shirahige K; Miyata N
    ChemMedChem; 2014 Mar; 9(3):657-64. PubMed ID: 24403121
    [TBL] [Abstract][Full Text] [Related]  

  • 37. Novel urushiol derivatives as HDAC8 inhibitors: rational design, virtual screening, molecular docking and molecular dynamics studies.
    Zhou H; Wang C; Deng T; Tao R; Li W
    J Biomol Struct Dyn; 2018 Jun; 36(8):1966-1978. PubMed ID: 28632421
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Structural studies of human histone deacetylase 8 and its site-specific variants complexed with substrate and inhibitors.
    Dowling DP; Gantt SL; Gattis SG; Fierke CA; Christianson DW
    Biochemistry; 2008 Dec; 47(51):13554-63. PubMed ID: 19053282
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Synthesis and biological evaluation of ortho-aryl N-hydroxycinnamides as potent histone deacetylase (HDAC) 8 isoform-selective inhibitors.
    Huang WJ; Wang YC; Chao SW; Yang CY; Chen LC; Lin MH; Hou WC; Chen MY; Lee TL; Yang P; Chang CI
    ChemMedChem; 2012 Oct; 7(10):1815-24. PubMed ID: 22907916
    [TBL] [Abstract][Full Text] [Related]  

  • 40. The structural requirements of histone deacetylase inhibitors: suberoylanilide hydroxamic acid analogs modified at the C6 position.
    Choi SE; Pflum MK
    Bioorg Med Chem Lett; 2012 Dec; 22(23):7084-6. PubMed ID: 23089527
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 19.