238 related articles for article (PubMed ID: 27385159)
1. Inhibition of Pyruvate Dehydrogenase Kinase 2 Protects Against Hepatic Steatosis Through Modulation of Tricarboxylic Acid Cycle Anaplerosis and Ketogenesis.
Go Y; Jeong JY; Jeoung NH; Jeon JH; Park BY; Kang HJ; Ha CM; Choi YK; Lee SJ; Ham HJ; Kim BG; Park KG; Park SY; Lee CH; Choi CS; Park TS; Lee WN; Harris RA; Lee IK
Diabetes; 2016 Oct; 65(10):2876-87. PubMed ID: 27385159
[TBL] [Abstract][Full Text] [Related]
2. Targeting hepatic pyruvate dehydrogenase kinases restores insulin signaling and mitigates ChREBP-mediated lipogenesis in diet-induced obese mice.
Wu CY; Tso SC; Chuang JL; Gui WJ; Lou M; Sharma G; Khemtong C; Qi X; Wynn RM; Chuang DT
Mol Metab; 2018 Jun; 12():12-24. PubMed ID: 29656110
[TBL] [Abstract][Full Text] [Related]
3. Lipotoxicity in steatohepatitis occurs despite an increase in tricarboxylic acid cycle activity.
Patterson RE; Kalavalapalli S; Williams CM; Nautiyal M; Mathew JT; Martinez J; Reinhard MK; McDougall DJ; Rocca JR; Yost RA; Cusi K; Garrett TJ; Sunny NE
Am J Physiol Endocrinol Metab; 2016 Apr; 310(7):E484-94. PubMed ID: 26814015
[TBL] [Abstract][Full Text] [Related]
4. The importance of pyruvate availability to PDC activation and anaplerosis in human skeletal muscle.
Constantin-Teodosiu D; Simpson EJ; Greenhaff PL
Am J Physiol; 1999 Mar; 276(3):E472-8. PubMed ID: 10070012
[TBL] [Abstract][Full Text] [Related]
5. Hepatic malonyl-CoA synthesis restrains gluconeogenesis by suppressing fat oxidation, pyruvate carboxylation, and amino acid availability.
Deja S; Fletcher JA; Kim CW; Kucejova B; Fu X; Mizerska M; Villegas M; Pudelko-Malik N; Browder N; Inigo-Vollmer M; Menezes CJ; Mishra P; Berglund ED; Browning JD; Thyfault JP; Young JD; Horton JD; Burgess SC
Cell Metab; 2024 May; 36(5):1088-1104.e12. PubMed ID: 38447582
[TBL] [Abstract][Full Text] [Related]
6. Pyruvate Dehydrogenase Kinase Is a Metabolic Checkpoint for Polarization of Macrophages to the M1 Phenotype.
Min BK; Park S; Kang HJ; Kim DW; Ham HJ; Ha CM; Choi BJ; Lee JY; Oh CJ; Yoo EK; Kim HE; Kim BG; Jeon JH; Hyeon DY; Hwang D; Kim YH; Lee CH; Lee T; Kim JW; Choi YK; Park KG; Chawla A; Lee J; Harris RA; Lee IK
Front Immunol; 2019; 10():944. PubMed ID: 31134063
[TBL] [Abstract][Full Text] [Related]
7. Dipeptidyl peptidase-4 inhibition ameliorates Western diet-induced hepatic steatosis and insulin resistance through hepatic lipid remodeling and modulation of hepatic mitochondrial function.
Aroor AR; Habibi J; Ford DA; Nistala R; Lastra G; Manrique C; Dunham MM; Ford KD; Thyfault JP; Parks EJ; Sowers JR; Rector RS
Diabetes; 2015 Jun; 64(6):1988-2001. PubMed ID: 25605806
[TBL] [Abstract][Full Text] [Related]
8. Therapeutic potential of the mammalian pyruvate dehydrogenase kinases in the prevention of hyperglycaemia.
Sugden MC; Holness MJ
Curr Drug Targets Immune Endocr Metabol Disord; 2002 Jul; 2(2):151-65. PubMed ID: 12476789
[TBL] [Abstract][Full Text] [Related]
9. Dimethylarginine Dimethylaminohydrolase 1 Protects Against High-Fat Diet-Induced Hepatic Steatosis and Insulin Resistance in Mice.
Li T; Feng R; Zhao C; Wang Y; Wang J; Liu S; Cao J; Wang H; Wang T; Guo Y; Lu Z
Antioxid Redox Signal; 2017 Apr; 26(11):598-609. PubMed ID: 27565538
[TBL] [Abstract][Full Text] [Related]
10. The odd-carbon medium-chain fatty triglyceride triheptanoin does not reduce hepatic steatosis.
Comhair TM; Garcia Caraballo SC; Dejong CH; Lamers WH; Koehler SE
Clin Nutr; 2017 Feb; 36(1):229-237. PubMed ID: 26778339
[TBL] [Abstract][Full Text] [Related]
11. Elevated TCA cycle function in the pathology of diet-induced hepatic insulin resistance and fatty liver.
Satapati S; Sunny NE; Kucejova B; Fu X; He TT; Méndez-Lucas A; Shelton JM; Perales JC; Browning JD; Burgess SC
J Lipid Res; 2012 Jun; 53(6):1080-92. PubMed ID: 22493093
[TBL] [Abstract][Full Text] [Related]
12. Abrogation of hepatic ATP-citrate lyase protects against fatty liver and ameliorates hyperglycemia in leptin receptor-deficient mice.
Wang Q; Jiang L; Wang J; Li S; Yu Y; You J; Zeng R; Gao X; Rui L; Li W; Liu Y
Hepatology; 2009 Apr; 49(4):1166-75. PubMed ID: 19177596
[TBL] [Abstract][Full Text] [Related]
13. Pyruvate dehydrogenase kinase 4 mediates lipogenesis and contributes to the pathogenesis of nonalcoholic steatohepatitis.
Zhang M; Zhao Y; Li Z; Wang C
Biochem Biophys Res Commun; 2018 Jan; 495(1):582-586. PubMed ID: 29128353
[TBL] [Abstract][Full Text] [Related]
14. Pyruvate-Carboxylase-Mediated Anaplerosis Promotes Antioxidant Capacity by Sustaining TCA Cycle and Redox Metabolism in Liver.
Cappel DA; Deja S; Duarte JAG; Kucejova B; Iñigo M; Fletcher JA; Fu X; Berglund ED; Liu T; Elmquist JK; Hammer S; Mishra P; Browning JD; Burgess SC
Cell Metab; 2019 Jun; 29(6):1291-1305.e8. PubMed ID: 31006591
[TBL] [Abstract][Full Text] [Related]
15. The pyruvate carboxylase-pyruvate dehydrogenase axis in islet pyruvate metabolism: Going round in circles?
Sugden MC; Holness MJ
Islets; 2011; 3(6):302-19. PubMed ID: 21934355
[TBL] [Abstract][Full Text] [Related]
16. Changes in Plasma Pyruvate and TCA Cycle Metabolites upon Increased Hepatic Fatty Acid Oxidation and Ketogenesis in Male Wistar Rats.
Dankel SN; Kalleklev TL; Tungland SL; Stafsnes MH; Bruheim P; Aloysius TA; Lindquist C; Skorve J; Nygård OK; Madsen L; Bjørndal B; Sydnes MO; Berge RK
Int J Mol Sci; 2023 Oct; 24(21):. PubMed ID: 37958519
[TBL] [Abstract][Full Text] [Related]
17. The mitochondrial pyruvate carrier mediates high fat diet-induced increases in hepatic TCA cycle capacity.
Rauckhorst AJ; Gray LR; Sheldon RD; Fu X; Pewa AD; Feddersen CR; Dupuy AJ; Gibson-Corley KN; Cox JE; Burgess SC; Taylor EB
Mol Metab; 2017 Nov; 6(11):1468-1479. PubMed ID: 29107293
[TBL] [Abstract][Full Text] [Related]
18. Genetic activation of pyruvate dehydrogenase alters oxidative substrate selection to induce skeletal muscle insulin resistance.
Rahimi Y; Camporez JP; Petersen MC; Pesta D; Perry RJ; Jurczak MJ; Cline GW; Shulman GI
Proc Natl Acad Sci U S A; 2014 Nov; 111(46):16508-13. PubMed ID: 25368185
[TBL] [Abstract][Full Text] [Related]
19. Investigation of potential mechanisms regulating protein expression of hepatic pyruvate dehydrogenase kinase isoforms 2 and 4 by fatty acids and thyroid hormone.
Holness MJ; Bulmer K; Smith ND; Sugden MC
Biochem J; 2003 Feb; 369(Pt 3):687-95. PubMed ID: 12435272
[TBL] [Abstract][Full Text] [Related]
20. Regulation of hepatic fat and glucose oxidation in rats with lipid-induced hepatic insulin resistance.
Alves TC; Befroy DE; Kibbey RG; Kahn M; Codella R; Carvalho RA; Falk Petersen K; Shulman GI
Hepatology; 2011 Apr; 53(4):1175-81. PubMed ID: 21400553
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
