768 related articles for article (PubMed ID: 27385183)
1. Transporter-Enzyme Interplay: Deconvoluting Effects of Hepatic Transporters and Enzymes on Drug Disposition Using Static and Dynamic Mechanistic Models.
Varma MV; El-Kattan AF
J Clin Pharmacol; 2016 Jul; 56 Suppl 7():S99-S109. PubMed ID: 27385183
[TBL] [Abstract][Full Text] [Related]
2. Evaluation and Quantitative Prediction of Renal Transporter-Mediated Drug-Drug Interactions.
Feng B; Varma MV
J Clin Pharmacol; 2016 Jul; 56 Suppl 7():S110-21. PubMed ID: 27385169
[TBL] [Abstract][Full Text] [Related]
3. Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: their roles in hepatic clearance and intestinal absorption.
Shitara Y; Maeda K; Ikejiri K; Yoshida K; Horie T; Sugiyama Y
Biopharm Drug Dispos; 2013 Jan; 34(1):45-78. PubMed ID: 23115084
[TBL] [Abstract][Full Text] [Related]
4. Transporter-enzyme interplay and the hepatic drug clearance: what have we learned so far?
Alluri RV; Li R; Varma MVS
Expert Opin Drug Metab Toxicol; 2020 May; 16(5):387-401. PubMed ID: 32228316
[No Abstract] [Full Text] [Related]
5. Navigating Transporter Sciences in Pharmacokinetics Characterization Using the Extended Clearance Classification System.
El-Kattan AF; Varma MVS
Drug Metab Dispos; 2018 May; 46(5):729-739. PubMed ID: 29496721
[TBL] [Abstract][Full Text] [Related]
6. Quantitative Analyses of the Influence of Parameters Governing Rate-Determining Process of Hepatic Elimination of Drugs on the Magnitudes of Drug-Drug Interactions via Hepatic OATPs and CYP3A Using Physiologically Based Pharmacokinetic Models.
Yoshikado T; Maeda K; Kusuhara H; Furihata KI; Sugiyama Y
J Pharm Sci; 2017 Sep; 106(9):2739-2750. PubMed ID: 28495568
[TBL] [Abstract][Full Text] [Related]
7. Importance of Hepatic Transporters in Clinical Disposition of Drugs and Their Metabolites.
Patel M; Taskar KS; Zamek-Gliszczynski MJ
J Clin Pharmacol; 2016 Jul; 56 Suppl 7():S23-39. PubMed ID: 27385177
[TBL] [Abstract][Full Text] [Related]
8. When Does the Rate-Determining Step in the Hepatic Clearance of a Drug Switch from Sinusoidal Uptake to All Hepatobiliary Clearances? Implications for Predicting Drug-Drug Interactions.
Patilea-Vrana GI; Unadkat JD
Drug Metab Dispos; 2018 Nov; 46(11):1487-1496. PubMed ID: 30115647
[TBL] [Abstract][Full Text] [Related]
9. Identification and quantitation of enzyme and transporter contributions to hepatic clearance for the assessment of potential drug-drug interactions.
Kimoto E; Obach RS; Varma MVS
Drug Metab Pharmacokinet; 2020 Feb; 35(1):18-29. PubMed ID: 31952912
[TBL] [Abstract][Full Text] [Related]
10. Prediction of pharmacokinetics and drug-drug interactions when hepatic transporters are involved.
Li R; Barton HA; Varma MV
Clin Pharmacokinet; 2014 Aug; 53(8):659-78. PubMed ID: 25056496
[TBL] [Abstract][Full Text] [Related]
11. Sandwich-Cultured Hepatocytes for Mechanistic Understanding of Hepatic Disposition of Parent Drugs and Metabolites by Transporter-Enzyme Interplay.
Matsunaga N; Fukuchi Y; Imawaka H; Tamai I
Drug Metab Dispos; 2018 May; 46(5):680-691. PubMed ID: 29352067
[TBL] [Abstract][Full Text] [Related]
12. The evolution of the OATP hepatic uptake transport protein family in DMPK sciences: from obscure liver transporters to key determinants of hepatobiliary clearance.
Fenner KS; Jones HM; Ullah M; Kempshall S; Dickins M; Lai Y; Morgan P; Barton HA
Xenobiotica; 2012 Jan; 42(1):28-45. PubMed ID: 22077101
[TBL] [Abstract][Full Text] [Related]
13. Projecting ADME Behavior and Drug-Drug Interactions in Early Discovery and Development: Application of the Extended Clearance Classification System.
El-Kattan AF; Varma MV; Steyn SJ; Scott DO; Maurer TS; Bergman A
Pharm Res; 2016 Dec; 33(12):3021-3030. PubMed ID: 27620173
[TBL] [Abstract][Full Text] [Related]
14. Prediction of Cyclosporin-Mediated Drug Interaction Using Physiologically Based Pharmacokinetic Model Characterizing Interplay of Drug Transporters and Enzymes.
Yang Y; Li P; Zhang Z; Wang Z; Liu L; Liu X
Int J Mol Sci; 2020 Sep; 21(19):. PubMed ID: 32987693
[TBL] [Abstract][Full Text] [Related]
15. Predicting Clearance Mechanism in Drug Discovery: Extended Clearance Classification System (ECCS).
Varma MV; Steyn SJ; Allerton C; El-Kattan AF
Pharm Res; 2015 Dec; 32(12):3785-802. PubMed ID: 26155985
[TBL] [Abstract][Full Text] [Related]
16. Transporter-mediated drug--drug interactions involving OATP substrates: predictions based on in vitro inhibition studies.
Yoshida K; Maeda K; Sugiyama Y
Clin Pharmacol Ther; 2012 Jun; 91(6):1053-64. PubMed ID: 22534868
[TBL] [Abstract][Full Text] [Related]
17. Model-based approaches to predict drug-drug interactions associated with hepatic uptake transporters: preclinical, clinical and beyond.
Barton HA; Lai Y; Goosen TC; Jones HM; El-Kattan AF; Gosset JR; Lin J; Varma MV
Expert Opin Drug Metab Toxicol; 2013 Apr; 9(4):459-72. PubMed ID: 23331046
[TBL] [Abstract][Full Text] [Related]
18. Organic anion transporting polypeptide (OATP)1B1 and OATP1B3 as important regulators of the pharmacokinetics of substrate drugs.
Maeda K
Biol Pharm Bull; 2015; 38(2):155-68. PubMed ID: 25747975
[TBL] [Abstract][Full Text] [Related]
19. Evaluation of cynomolgus monkeys for the identification of endogenous biomarkers for hepatic transporter inhibition and as a translatable model to predict pharmacokinetic interactions with statins in humans.
Chu X; Shih SJ; Shaw R; Hentze H; Chan GH; Owens K; Wang S; Cai X; Newton D; Castro-Perez J; Salituro G; Palamanda J; Fernandis A; Ng CK; Liaw A; Savage MJ; Evers R
Drug Metab Dispos; 2015 Jun; 43(6):851-63. PubMed ID: 25813937
[TBL] [Abstract][Full Text] [Related]
20. Organic Anion Transporter 2-Mediated Hepatic Uptake Contributes to the Clearance of High-Permeability-Low-Molecular-Weight Acid and Zwitterion Drugs: Evaluation Using 25 Drugs.
Kimoto E; Mathialagan S; Tylaska L; Niosi M; Lin J; Carlo AA; Tess DA; Varma MVS
J Pharmacol Exp Ther; 2018 Nov; 367(2):322-334. PubMed ID: 30135178
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]