BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

502 related articles for article (PubMed ID: 27432743)

  • 1. An Investigational RNAi Therapeutic Targeting Glycolate Oxidase Reduces Oxalate Production in Models of Primary Hyperoxaluria.
    Liebow A; Li X; Racie T; Hettinger J; Bettencourt BR; Najafian N; Haslett P; Fitzgerald K; Holmes RP; Erbe D; Querbes W; Knight J
    J Am Soc Nephrol; 2017 Feb; 28(2):494-503. PubMed ID: 27432743
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Inhibition of Glycolate Oxidase With Dicer-substrate siRNA Reduces Calcium Oxalate Deposition in a Mouse Model of Primary Hyperoxaluria Type 1.
    Dutta C; Avitahl-Curtis N; Pursell N; Larsson Cohen M; Holmes B; Diwanji R; Zhou W; Apponi L; Koser M; Ying B; Chen D; Shui X; Saxena U; Cyr WA; Shah A; Nazef N; Wang W; Abrams M; Dudek H; Salido E; Brown BD; Lai C
    Mol Ther; 2016 Apr; 24(4):770-8. PubMed ID: 26758691
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Metabolism of (13)C5-hydroxyproline in mouse models of Primary Hyperoxaluria and its inhibition by RNAi therapeutics targeting liver glycolate oxidase and hydroxyproline dehydrogenase.
    Li X; Knight J; Fargue S; Buchalski B; Guan Z; Inscho EW; Liebow A; Fitzgerald K; Querbes W; Todd Lowther W; Holmes RP
    Biochim Biophys Acta; 2016 Feb; 1862(2):233-9. PubMed ID: 26655602
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Systemic Alanine Glyoxylate Aminotransferase mRNA Improves Glyoxylate Metabolism in a Mouse Model of Primary Hyperoxaluria Type 1.
    Kukreja A; Lasaro M; Cobaugh C; Forbes C; Tang JP; Gao X; Martin-Higueras C; Pey AL; Salido E; Sobolov S; Subramanian RR
    Nucleic Acid Ther; 2019 Apr; 29(2):104-113. PubMed ID: 30676254
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Specific Inhibition of Hepatic Lactate Dehydrogenase Reduces Oxalate Production in Mouse Models of Primary Hyperoxaluria.
    Lai C; Pursell N; Gierut J; Saxena U; Zhou W; Dills M; Diwanji R; Dutta C; Koser M; Nazef N; Storr R; Kim B; Martin-Higueras C; Salido E; Wang W; Abrams M; Dudek H; Brown BD
    Mol Ther; 2018 Aug; 26(8):1983-1995. PubMed ID: 29914758
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Lumasiran, an RNAi Therapeutic for Primary Hyperoxaluria Type 1.
    Garrelfs SF; Frishberg Y; Hulton SA; Koren MJ; O'Riordan WD; Cochat P; Deschênes G; Shasha-Lavsky H; Saland JM; Van't Hoff WG; Fuster DG; Magen D; Moochhala SH; Schalk G; Simkova E; Groothoff JW; Sas DJ; Meliambro KA; Lu J; Sweetser MT; Garg PP; Vaishnaw AK; Gansner JM; McGregor TL; Lieske JC;
    N Engl J Med; 2021 Apr; 384(13):1216-1226. PubMed ID: 33789010
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Re: An Investigational RNAi Therapeutic Targeting Glycolate Oxidase Reduces Oxalate Production in Models of Primary Hyperoxaluria.
    Assimos DG
    J Urol; 2017 May; 197(5):1297-1298. PubMed ID: 29539912
    [No Abstract]   [Full Text] [Related]  

  • 8. Lumasiran for Advanced Primary Hyperoxaluria Type 1: Phase 3 ILLUMINATE-C Trial.
    Michael M; Groothoff JW; Shasha-Lavsky H; Lieske JC; Frishberg Y; Simkova E; Sellier-Leclerc AL; Devresse A; Guebre-Egziabher F; Bakkaloglu SA; Mourani C; Saqan R; Singer R; Willey R; Habtemariam B; Gansner JM; Bhan I; McGregor T; Magen D
    Am J Kidney Dis; 2023 Feb; 81(2):145-155.e1. PubMed ID: 35843439
    [TBL] [Abstract][Full Text] [Related]  

  • 9. New therapeutics for primary hyperoxaluria type 1.
    Dejban P; Lieske JC
    Curr Opin Nephrol Hypertens; 2022 Jul; 31(4):344-350. PubMed ID: 35266883
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The effects of the inactivation of Hydroxyproline dehydrogenase on urinary oxalate and glycolate excretion in mouse models of primary hyperoxaluria.
    Buchalski B; Wood KD; Challa A; Fargue S; Holmes RP; Lowther WT; Knight J
    Biochim Biophys Acta Mol Basis Dis; 2020 Mar; 1866(3):165633. PubMed ID: 31821850
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Therapeutic RNA interference: A novel approach to the treatment of primary hyperoxaluria.
    Forbes TA; Brown BD; Lai C
    Br J Clin Pharmacol; 2022 Jun; 88(6):2525-2538. PubMed ID: 34022071
    [TBL] [Abstract][Full Text] [Related]  

  • 12. CRISPR/Cas9-mediated glycolate oxidase disruption is an efficacious and safe treatment for primary hyperoxaluria type I.
    Zabaleta N; Barberia M; Martin-Higueras C; Zapata-Linares N; Betancor I; Rodriguez S; Martinez-Turrillas R; Torella L; Vales A; Olagüe C; Vilas-Zornoza A; Castro-Labrador L; Lara-Astiaso D; Prosper F; Salido E; Gonzalez-Aseguinolaza G; Rodriguez-Madoz JR
    Nat Commun; 2018 Dec; 9(1):5454. PubMed ID: 30575740
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Effects of alanine:glyoxylate aminotransferase variants and pyridoxine sensitivity on oxalate metabolism in a cell-based cytotoxicity assay.
    Fargue S; Knight J; Holmes RP; Rumsby G; Danpure CJ
    Biochim Biophys Acta; 2016 Jun; 1862(6):1055-62. PubMed ID: 26854734
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Hydroxyproline metabolism in mouse models of primary hyperoxaluria.
    Knight J; Holmes RP; Cramer SD; Takayama T; Salido E
    Am J Physiol Renal Physiol; 2012 Mar; 302(6):F688-93. PubMed ID: 22189945
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Glycolate Oxidase Is a Safe and Efficient Target for Substrate Reduction Therapy in a Mouse Model of Primary Hyperoxaluria Type I.
    Martin-Higueras C; Luis-Lima S; Salido E
    Mol Ther; 2016 Apr; 24(4):719-25. PubMed ID: 26689264
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Generation and characterization of a novel rat model of primary hyperoxaluria type 1 with a nonsense mutation in alanine-glyoxylate aminotransferase gene.
    Li Y; Zheng R; Xu G; Huang Y; Li Y; Li D; Geng H
    Am J Physiol Renal Physiol; 2021 Mar; 320(3):F475-F484. PubMed ID: 33491567
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Hepatic alanine-glyoxylate aminotransferase activity and oxalate metabolism in vitamin B6 deficient rats.
    Nishijima S; Sugaya K; Morozumi M; Hatano T; Ogawa Y
    J Urol; 2003 Feb; 169(2):683-6. PubMed ID: 12544342
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Primary hyperoxaluria type 1: novel therapies at a glance.
    Bacchetta J; Lieske JC
    Clin Kidney J; 2022 May; 15(Suppl 1):i17-i22. PubMed ID: 35592618
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Phase 1/2 Study of Lumasiran for Treatment of Primary Hyperoxaluria Type 1: A Placebo-Controlled Randomized Clinical Trial.
    Frishberg Y; Deschênes G; Groothoff JW; Hulton SA; Magen D; Harambat J; Van't Hoff WG; Lorch U; Milliner DS; Lieske JC; Haslett P; Garg PP; Vaishnaw AK; Talamudupula S; Lu J; Habtemariam BA; Erbe DV; McGregor TL; Cochat P;
    Clin J Am Soc Nephrol; 2021 Jul; 16(7):1025-1036. PubMed ID: 33985991
    [TBL] [Abstract][Full Text] [Related]  

  • 20.
    ; ; . PubMed ID:
    [No Abstract]   [Full Text] [Related]  

    [Next]    [New Search]
    of 26.