These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

158 related articles for article (PubMed ID: 27452145)

  • 1. Metabolic Precision Medicines: Curing POMC Deficiency.
    Müller TD; Tschöp MH; O'Rahilly S
    Cell Metab; 2016 Aug; 24(2):194-5. PubMed ID: 27452145
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Efficacy and safety of setmelanotide, an MC4R agonist, in individuals with severe obesity due to LEPR or POMC deficiency: single-arm, open-label, multicentre, phase 3 trials.
    Clément K; van den Akker E; Argente J; Bahm A; Chung WK; Connors H; De Waele K; Farooqi IS; Gonneau-Lejeune J; Gordon G; Kohlsdorf K; Poitou C; Puder L; Swain J; Stewart M; Yuan G; Wabitsch M; Kühnen P;
    Lancet Diabetes Endocrinol; 2020 Dec; 8(12):960-970. PubMed ID: 33137293
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Evaluation of a melanocortin-4 receptor (MC4R) agonist (Setmelanotide) in MC4R deficiency.
    Collet TH; Dubern B; Mokrosinski J; Connors H; Keogh JM; Mendes de Oliveira E; Henning E; Poitou-Bernert C; Oppert JM; Tounian P; Marchelli F; Alili R; Le Beyec J; Pépin D; Lacorte JM; Gottesdiener A; Bounds R; Sharma S; Folster C; Henderson B; O'Rahilly S; Stoner E; Gottesdiener K; Panaro BL; Cone RD; Clément K; Farooqi IS; Van der Ploeg LHT
    Mol Metab; 2017 Oct; 6(10):1321-1329. PubMed ID: 29031731
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Pro-opiomelanocortin (POMC) deficiency and peripheral melanocortins in obesity.
    Zemel MB; Shi H
    Nutr Rev; 2000 Jun; 58(6):177-80. PubMed ID: 10885325
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Proopiomelanocortin Deficiency Treated with a Melanocortin-4 Receptor Agonist.
    Kühnen P; Clément K; Wiegand S; Blankenstein O; Gottesdiener K; Martini LL; Mai K; Blume-Peytavi U; Grüters A; Krude H
    N Engl J Med; 2016 Jul; 375(3):240-6. PubMed ID: 27468060
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Two Cases With an Early Presented Proopiomelanocortin Deficiency-A Long-Term Follow-Up and Systematic Literature Review.
    Gregoric N; Groselj U; Bratina N; Debeljak M; Zerjav Tansek M; Suput Omladic J; Kovac J; Battelino T; Kotnik P; Avbelj Stefanija M
    Front Endocrinol (Lausanne); 2021; 12():689387. PubMed ID: 34177811
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Quality of life outcomes in two phase 3 trials of setmelanotide in patients with obesity due to LEPR or POMC deficiency.
    Kühnen P; Wabitsch M; von Schnurbein J; Chirila C; Mallya UG; Callahan P; Gnanasakthy A; Poitou C; Krabusch PM; Stewart M; Clément K
    Orphanet J Rare Dis; 2022 Feb; 17(1):38. PubMed ID: 35123544
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Effects of pro-opiomelanocortin (POMC) on food intake and body weight: mechanisms and therapeutic potential?
    Coll AP
    Clin Sci (Lond); 2007 Aug; 113(4):171-82. PubMed ID: 17623013
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Setmelanotide: a promising advancement for pediatric patients with rare forms of genetic obesity.
    Trapp CM; Censani M
    Curr Opin Endocrinol Diabetes Obes; 2023 Apr; 30(2):136-140. PubMed ID: 36722447
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Mitochondrial uncoupling in the melanocortin system differentially regulates NPY and POMC neurons to promote weight-loss.
    Michael NJ; Simonds SE; van den Top M; Cowley MA; Spanswick D
    Mol Metab; 2017 Oct; 6(10):1103-1112. PubMed ID: 29031712
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A Patient with Proopiomelanocortin Deficiency: An Increasingly Important Diagnosis to Make.
    Çetinkaya S; Güran T; Kurnaz E; Keskin M; Sağsak E; Savaş Erdeve S; Suntharalingham JP; Buonocore F; Achermann JC; Aycan Z
    J Clin Res Pediatr Endocrinol; 2018 Mar; 10(1):68-73. PubMed ID: 28739551
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Long-Term MC4R Agonist Treatment in POMC-Deficient Patients.
    Kühnen P; Clément K
    N Engl J Med; 2022 Sep; 387(9):852-854. PubMed ID: 36053514
    [No Abstract]   [Full Text] [Related]  

  • 13. Magel2-null mice are hyper-responsive to setmelanotide, a melanocortin 4 receptor agonist.
    Bischof JM; Van Der Ploeg LH; Colmers WF; Wevrick R
    Br J Pharmacol; 2016 Sep; 173(17):2614-21. PubMed ID: 27339818
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Pro-Opiomelanocortin (POMC) Neurones, POMC-Derived Peptides, Melanocortin Receptors and Obesity: How Understanding of this System has Changed Over the Last Decade.
    Mountjoy KG
    J Neuroendocrinol; 2015 Jun; 27(6):406-18. PubMed ID: 25872650
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Understanding the Patient Experience of Hunger and Improved Quality of Life with Setmelanotide Treatment in POMC and LEPR Deficiencies.
    Wabitsch M; Fehnel S; Mallya UG; Sluga-O'Callaghan M; Richardson D; Price M; Kühnen P
    Adv Ther; 2022 Apr; 39(4):1772-1783. PubMed ID: 35192151
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Setmelanotide: First Approval.
    Markham A
    Drugs; 2021 Feb; 81(3):397-403. PubMed ID: 33638809
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Obesity due to proopiomelanocortin deficiency: three new cases and treatment trials with thyroid hormone and ACTH4-10.
    Krude H; Biebermann H; Schnabel D; Tansek MZ; Theunissen P; Mullis PE; Grüters A
    J Clin Endocrinol Metab; 2003 Oct; 88(10):4633-40. PubMed ID: 14557433
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Pro-opiomelanocortin processing in the hypothalamus: impact on melanocortin signalling and obesity.
    Pritchard LE; Turnbull AV; White A
    J Endocrinol; 2002 Mar; 172(3):411-21. PubMed ID: 11874690
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Melanocortin 4 Receptor Pathway Dysfunction in Obesity: Patient Stratification Aimed at MC4R Agonist Treatment.
    Ayers KL; Glicksberg BS; Garfield AS; Longerich S; White JA; Yang P; Du L; Chittenden TW; Gulcher JR; Roy S; Fiedorek F; Gottesdiener K; Cohen S; North KE; Schadt EE; Li SD; Chen R; Van der Ploeg LHT
    J Clin Endocrinol Metab; 2018 Jul; 103(7):2601-2612. PubMed ID: 29726959
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Rare genetic forms of obesity: From gene to therapy.
    Clément K; Mosbah H; Poitou C
    Physiol Behav; 2020 Dec; 227():113134. PubMed ID: 32805220
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.