727 related articles for article (PubMed ID: 27460699)
1. Synthesis and evaluation of multi-target-directed ligands for the treatment of Alzheimer's disease based on the fusion of donepezil and melatonin.
Wang J; Wang ZM; Li XM; Li F; Wu JJ; Kong LY; Wang XB
Bioorg Med Chem; 2016 Sep; 24(18):4324-4338. PubMed ID: 27460699
[TBL] [Abstract][Full Text] [Related]
2. Design, synthesis and biological activity of novel donepezil derivatives bearing N-benzyl pyridinium moiety as potent and dual binding site acetylcholinesterase inhibitors.
Lan JS; Zhang T; Liu Y; Yang J; Xie SS; Liu J; Miao ZY; Ding Y
Eur J Med Chem; 2017 Jun; 133():184-196. PubMed ID: 28388521
[TBL] [Abstract][Full Text] [Related]
3. Design, synthesis and evaluation of novel tacrine-(β-carboline) hybrids as multifunctional agents for the treatment of Alzheimer's disease.
Lan JS; Xie SS; Li SY; Pan LF; Wang XB; Kong LY
Bioorg Med Chem; 2014 Nov; 22(21):6089-104. PubMed ID: 25282654
[TBL] [Abstract][Full Text] [Related]
4. Synthesis and evaluation of multi-target-directed ligands against Alzheimer's disease based on the fusion of donepezil and ebselen.
Luo Z; Sheng J; Sun Y; Lu C; Yan J; Liu A; Luo HB; Huang L; Li X
J Med Chem; 2013 Nov; 56(22):9089-99. PubMed ID: 24160297
[TBL] [Abstract][Full Text] [Related]
5. Rational modification of donepezil as multifunctional acetylcholinesterase inhibitors for the treatment of Alzheimer's disease.
Wang ZM; Cai P; Liu QH; Xu DQ; Yang XL; Wu JJ; Kong LY; Wang XB
Eur J Med Chem; 2016 Nov; 123():282-297. PubMed ID: 27484514
[TBL] [Abstract][Full Text] [Related]
6. Rational Design and Multibiological Profiling of Novel Donepezil-Trolox Hybrids against Alzheimer's Disease, with Cholinergic, Antioxidant, Neuroprotective, and Cognition Enhancing Properties.
Cai P; Fang SQ; Yang XL; Wu JJ; Liu QH; Hong H; Wang XB; Kong LY
ACS Chem Neurosci; 2017 Nov; 8(11):2496-2511. PubMed ID: 28806057
[TBL] [Abstract][Full Text] [Related]
7. Design, synthesis and biological evaluation of novel deoxyvasicinone-indole as multi-target agents for Alzheimer's disease.
Nerella A; Jeripothula M
Bioorg Med Chem Lett; 2021 Oct; 49():128212. PubMed ID: 34153471
[TBL] [Abstract][Full Text] [Related]
8. Synthesis and pharmacological evaluation of donepezil-based agents as new cholinesterase/monoamine oxidase inhibitors for the potential application against Alzheimer's disease.
Li F; Wang ZM; Wu JJ; Wang J; Xie SS; Lan JS; Xu W; Kong LY; Wang XB
J Enzyme Inhib Med Chem; 2016; 31(sup3):41-53. PubMed ID: 27384289
[TBL] [Abstract][Full Text] [Related]
9. Synthesis, biological evaluation, and molecular modeling of donepezil and N-[(5-(benzyloxy)-1-methyl-1H-indol-2-yl)methyl]-N-methylprop-2-yn-1-amine hybrids as new multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease.
Bolea I; Juárez-Jiménez J; de Los Ríos C; Chioua M; Pouplana R; Luque FJ; Unzeta M; Marco-Contelles J; Samadi A
J Med Chem; 2011 Dec; 54(24):8251-70. PubMed ID: 22023459
[TBL] [Abstract][Full Text] [Related]
10. Design, synthesis, and evaluation of multitarget-directed ligands against Alzheimer's disease based on the fusion of donepezil and curcumin.
Yan J; Hu J; Liu A; He L; Li X; Wei H
Bioorg Med Chem; 2017 Jun; 25(12):2946-2955. PubMed ID: 28454848
[TBL] [Abstract][Full Text] [Related]
11. Design, synthesis and biological activity of novel tacrine-isatin Schiff base hybrid derivatives.
Riazimontazer E; Sadeghpour H; Nadri H; Sakhteman A; Tüylü Küçükkılınç T; Miri R; Edraki N
Bioorg Chem; 2019 Aug; 89():103006. PubMed ID: 31158577
[TBL] [Abstract][Full Text] [Related]
12. Synthesis, biological evaluation and molecular docking study of novel piperidine and piperazine derivatives as multi-targeted agents to treat Alzheimer's disease.
Meena P; Nemaysh V; Khatri M; Manral A; Luthra PM; Tiwari M
Bioorg Med Chem; 2015 Mar; 23(5):1135-48. PubMed ID: 25624107
[TBL] [Abstract][Full Text] [Related]
13. Discovery of indanone derivatives as multi-target-directed ligands against Alzheimer's disease.
Huang L; Miao H; Sun Y; Meng F; Li X
Eur J Med Chem; 2014 Nov; 87():429-39. PubMed ID: 25282266
[TBL] [Abstract][Full Text] [Related]
14. Design, Synthesis and Biological Evaluation of Xanthone Derivatives for Possible Treatment of Alzheimer's Disease Based on Multi-Target Strategy.
Yang A; Yu Q; Ju H; Song L; Kou X; Shen R
Chem Biodivers; 2020 Oct; 17(10):e2000442. PubMed ID: 32692899
[TBL] [Abstract][Full Text] [Related]
15. Donepezil-butylated hydroxytoluene (BHT) hybrids as Anti-Alzheimer's disease agents with cholinergic, antioxidant, and neuroprotective properties.
Cai P; Fang SQ; Yang HL; Yang XL; Liu QH; Kong LY; Wang XB
Eur J Med Chem; 2018 Sep; 157():161-176. PubMed ID: 30096650
[TBL] [Abstract][Full Text] [Related]
16. 1-Benzylpyrrolidine-3-amine-based BuChE inhibitors with anti-aggregating, antioxidant and metal-chelating properties as multifunctional agents against Alzheimer's disease.
Wichur T; Więckowska A; Więckowski K; Godyń J; Jończyk J; Valdivieso ÁDR; Panek D; Pasieka A; Sabaté R; Knez D; Gobec S; Malawska B
Eur J Med Chem; 2020 Feb; 187():111916. PubMed ID: 31812794
[TBL] [Abstract][Full Text] [Related]
17. Multipotent cholinesterase/monoamine oxidase inhibitors for the treatment of Alzheimer's disease: design, synthesis, biochemical evaluation, ADMET, molecular modeling, and QSAR analysis of novel donepezil-pyridyl hybrids.
Bautista-Aguilera OM; Esteban G; Chioua M; Nikolic K; Agbaba D; Moraleda I; Iriepa I; Soriano E; Samadi A; Unzeta M; Marco-Contelles J
Drug Des Devel Ther; 2014; 8():1893-910. PubMed ID: 25378907
[TBL] [Abstract][Full Text] [Related]
18. Novel chromanone-dithiocarbamate hybrids as multifunctional AChE inhibitors with β-amyloid anti-aggregation properties for the treatment of Alzheimer's disease.
Jiang N; Ding J; Liu J; Sun X; Zhang Z; Mo Z; Li X; Yin H; Tang W; Xie SS
Bioorg Chem; 2019 Aug; 89():103027. PubMed ID: 31176237
[TBL] [Abstract][Full Text] [Related]
19. Synthesis, pharmacology and molecular docking on multifunctional tacrine-ferulic acid hybrids as cholinesterase inhibitors against Alzheimer's disease.
Zhu J; Yang H; Chen Y; Lin H; Li Q; Mo J; Bian Y; Pei Y; Sun H
J Enzyme Inhib Med Chem; 2018 Dec; 33(1):496-506. PubMed ID: 29405075
[TBL] [Abstract][Full Text] [Related]
20. Design, synthesis and biological evaluation of novel donepezil-coumarin hybrids as multi-target agents for the treatment of Alzheimer's disease.
Xie SS; Lan JS; Wang X; Wang ZM; Jiang N; Li F; Wu JJ; Wang J; Kong LY
Bioorg Med Chem; 2016 Apr; 24(7):1528-39. PubMed ID: 26917219
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]