196 related articles for article (PubMed ID: 27462143)
1. Effect of N-methyl deuteration on metabolism and pharmacokinetics of enzalutamide.
Jiang J; Pang X; Li L; Dai X; Diao X; Chen X; Zhong D; Wang Y; Chen Y
Drug Des Devel Ther; 2016; 10():2181-91. PubMed ID: 27462143
[TBL] [Abstract][Full Text] [Related]
2. Application of a deuterium replacement strategy to modulate the pharmacokinetics of 7-(3,5-dimethyl-1H-1,2,4-triazol-1-yl)-3-(4-methoxy-2-methylphenyl)-2,6-dimethylpyrazolo[5,1-b]oxazole, a novel CRF1 antagonist.
Stringer RA; Williams G; Picard F; Sohal B; Kretz O; McKenna J; Krauser JA
Drug Metab Dispos; 2014 May; 42(5):954-62. PubMed ID: 24616265
[TBL] [Abstract][Full Text] [Related]
3. Effect of N-methyl deuteration on pharmacokinetics and pharmacodynamics of enzalutamide.
Pang X; Peng L; Chen Y
J Labelled Comp Radiopharm; 2017 Jul; 60(9):401-409. PubMed ID: 28432800
[TBL] [Abstract][Full Text] [Related]
4. Altering Metabolic Profiles of Drugs by Precision Deuteration 2: Discovery of a Deuterated Analog of Ivacaftor with Differentiated Pharmacokinetics for Clinical Development.
Harbeson SL; Morgan AJ; Liu JF; Aslanian AM; Nguyen S; Bridson GW; Brummel CL; Wu L; Tung RD; Pilja L; Braman V; Uttamsingh V
J Pharmacol Exp Ther; 2017 Aug; 362(2):359-367. PubMed ID: 28611092
[TBL] [Abstract][Full Text] [Related]
5. Deuterium isotope effects in drug pharmacokinetics II: Substrate-dependence of the reaction mechanism influences outcome for cytochrome P450 cleared drugs.
Sun H; Piotrowski DW; Orr STM; Warmus JS; Wolford AC; Coffey SB; Futatsugi K; Zhang Y; Vaz ADN
PLoS One; 2018; 13(11):e0206279. PubMed ID: 30427871
[TBL] [Abstract][Full Text] [Related]
6. The kinetic deuterium isotope effect as applied to metabolic deactivation of imatinib to the des-methyl metabolite, CGP74588.
Manley PW; Blasco F; Mestan J; Aichholz R
Bioorg Med Chem; 2013 Jun; 21(11):3231-9. PubMed ID: 23611771
[TBL] [Abstract][Full Text] [Related]
7. A rapid MS/MS method to assess the deuterium kinetic isotope effect and associated improvement in the metabolic stability of deuterated biological and pharmacological molecules as applied to an imaging agent.
Murphy RB; Wyatt NA; Fraser BH; Yepuri NR; Holden PJ; Wotherspoon ATL; Darwish TA
Anal Chim Acta; 2019 Aug; 1064():65-70. PubMed ID: 30982519
[TBL] [Abstract][Full Text] [Related]
8. In vivo clearance of ethoxycoumarin and its prediction from In vitro systems. Use Of drug depletion and metabolite formation methods in hepatic microsomes and isolated hepatocytes.
Carlile DJ; Stevens AJ; Ashforth EI; Waghela D; Houston JB
Drug Metab Dispos; 1998 Mar; 26(3):216-21. PubMed ID: 9492383
[TBL] [Abstract][Full Text] [Related]
9. Absorption, Distribution, Metabolism, and Excretion of the Androgen Receptor Inhibitor Enzalutamide in Rats and Dogs.
Ohtsu Y; Gibbons JA; Suzuki K; Fitzsimmons ME; Nozawa K; Arai H
Eur J Drug Metab Pharmacokinet; 2017 Aug; 42(4):611-626. PubMed ID: 27590197
[TBL] [Abstract][Full Text] [Related]
10. Deuterium isotope effect on the metabolism of N-nitrosodimethylamine and related compounds by cytochrome P4502E1.
Yang CS; Ishizaki H
Xenobiotica; 1992; 22(9-10):1165-73. PubMed ID: 1441607
[TBL] [Abstract][Full Text] [Related]
11. Distal kinetic deuterium isotope effect: Phenyl ring deuteration attenuates N-demethylation of Lu AF35700.
Gjervig Jensen K; Tornby Christoffersen C; Graulund Hvenegaard M; Didriksen M; Jørgensen M
Bioorg Med Chem Lett; 2022 Sep; 72():128879. PubMed ID: 35809818
[TBL] [Abstract][Full Text] [Related]
12. Effects of deuteration on transamination and oxidation of hyperpolarized
Funk AM; Wen X; Hever T; Maptue NR; Khemtong C; Sherry AD; Malloy CR
J Magn Reson; 2019 Apr; 301():102-108. PubMed ID: 30861456
[TBL] [Abstract][Full Text] [Related]
13. Pharmacokinetics of enzalutamide, an anti-prostate cancer drug, in rats.
Kim TH; Jeong JW; Song JH; Lee KR; Ahn S; Ahn SH; Kim S; Koo TS
Arch Pharm Res; 2015 Nov; 38(11):2076-82. PubMed ID: 25956695
[TBL] [Abstract][Full Text] [Related]
14. Intramolecular deuterium isotope effect and enantiotopic differentiation in oxidative demethylation of chiral [monomethyl-d3]methoxychlor in rat liver microsomes.
Ichinose R; Kurihara N
Biochem Pharmacol; 1987 Nov; 36(21):3751-6. PubMed ID: 3675629
[TBL] [Abstract][Full Text] [Related]
15. Investigation of the mechanistic basis of N,N-dimethylformamide toxicity. Metabolism of N,N-dimethylformamide and its deuterated isotopomers by cytochrome P450 2E1.
Mráz J; Jheeta P; Gescher A; Hyland R; Thummel K; Threadgill MD
Chem Res Toxicol; 1993; 6(2):197-207. PubMed ID: 8477011
[TBL] [Abstract][Full Text] [Related]
16. Pharmacokinetics and Safety of Enzalutamide in Healthy Chinese Male Volunteers.
Liu YM; Wu P; Fukushi R; Yamada S; Chen Q
Clin Ther; 2019 Feb; 41(2):261-268. PubMed ID: 30642613
[TBL] [Abstract][Full Text] [Related]
17. The use of isotope effects to determine enzyme mechanisms.
Cleland WW
Arch Biochem Biophys; 2005 Jan; 433(1):2-12. PubMed ID: 15581561
[TBL] [Abstract][Full Text] [Related]
18. Deuterium isotope effects on drug pharmacokinetics. I. System-dependent effects of specific deuteration with aldehyde oxidase cleared drugs.
Sharma R; Strelevitz TJ; Gao H; Clark AJ; Schildknegt K; Obach RS; Ripp SL; Spracklin DK; Tremaine LM; Vaz AD
Drug Metab Dispos; 2012 Mar; 40(3):625-34. PubMed ID: 22190693
[TBL] [Abstract][Full Text] [Related]
19. Metabolism and pharmacokinetic study of deuterated osimertinib.
Zhan X; Bao S; Li X; Zhou S; Dahar MR; Lin N; Chen X; Niu C; Ji K; Wu Y; Zeng K; Tang Z; Yu L
Biopharm Drug Dispos; 2023 Apr; 44(2):165-174. PubMed ID: 36649539
[TBL] [Abstract][Full Text] [Related]
20. Significant species difference in amide hydrolysis of GDC-0834, a novel potent and selective Bruton's tyrosine kinase inhibitor.
Liu L; Halladay JS; Shin Y; Wong S; Coraggio M; La H; Baumgardner M; Le H; Gopaul S; Boggs J; Kuebler P; Davis JC; Liao XC; Lubach JW; Deese A; Sowell CG; Currie KS; Young WB; Khojasteh SC; Hop CE; Wong H
Drug Metab Dispos; 2011 Oct; 39(10):1840-9. PubMed ID: 21742900
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
