131 related articles for article (PubMed ID: 27480927)
1. Crystal structure of the kinase domain of human protein tyrosine kinase 6 (PTK6) at 2.33 Å resolution.
Thakur MK; Kumar A; Birudukota S; Swaminathan S; Tyagi R; Gosu R
Biochem Biophys Res Commun; 2016 Sep; 478(2):637-42. PubMed ID: 27480927
[TBL] [Abstract][Full Text] [Related]
2. Co-crystal structures of PTK6: With Dasatinib at 2.24 Å, with novel imidazo[1,2-a]pyrazin-8-amine derivative inhibitor at 1.70 Å resolution.
Thakur MK; Birudukota S; Swaminathan S; Battula SK; Vadivelu S; Tyagi R; Gosu R
Biochem Biophys Res Commun; 2017 Jan; 482(4):1289-1295. PubMed ID: 27993680
[TBL] [Abstract][Full Text] [Related]
3. Small molecule inhibitors reveal PTK6 kinase is not an oncogenic driver in breast cancers.
Qiu L; Levine K; Gajiwala KS; Cronin CN; Nagata A; Johnson E; Kraus M; Tatlock J; Kania R; Foley T; Sun S
PLoS One; 2018; 13(6):e0198374. PubMed ID: 29879184
[TBL] [Abstract][Full Text] [Related]
4. An intramolecular interaction between SH2-kinase linker and kinase domain is essential for the catalytic activity of protein-tyrosine kinase-6.
Kim HIe; Lee ST
J Biol Chem; 2005 Aug; 280(32):28973-80. PubMed ID: 15961400
[TBL] [Abstract][Full Text] [Related]
5. Solution structure and backbone dynamics of the non-receptor protein-tyrosine kinase-6 Src homology 2 domain.
Hong E; Shin J; Kim HI; Lee ST; Lee W
J Biol Chem; 2004 Jul; 279(28):29700-8. PubMed ID: 15056653
[TBL] [Abstract][Full Text] [Related]
6. Building a better understanding of the intracellular tyrosine kinase PTK6 - BRK by BRK.
Brauer PM; Tyner AL
Biochim Biophys Acta; 2010 Aug; 1806(1):66-73. PubMed ID: 20193745
[TBL] [Abstract][Full Text] [Related]
7. Protein tyrosine kinase 6 directly phosphorylates AKT and promotes AKT activation in response to epidermal growth factor.
Zheng Y; Peng M; Wang Z; Asara JM; Tyner AL
Mol Cell Biol; 2010 Sep; 30(17):4280-92. PubMed ID: 20606012
[TBL] [Abstract][Full Text] [Related]
8. Exon-intron structure of the human PTK6 gene demonstrates that PTK6 constitutes a distinct family of non-receptor tyrosine kinase.
Lee H; Kim M; Lee KH; Kang KN; Lee ST
Mol Cells; 1998 Aug; 8(4):401-7. PubMed ID: 9749526
[TBL] [Abstract][Full Text] [Related]
9. Molecular dissection of the interaction between the SH3 domain and the SH2-Kinase Linker region in PTK6.
Kim HIe; Jung J; Lee ES; Kim YC; Lee W; Lee ST
Biochem Biophys Res Commun; 2007 Nov; 362(4):829-34. PubMed ID: 17822667
[TBL] [Abstract][Full Text] [Related]
10. PTK6/BRK is expressed in the normal mammary gland and activated at the plasma membrane in breast tumors.
Peng M; Emmadi R; Wang Z; Wiley EL; Gann PH; Khan SA; Banerji N; McDonald W; Asztalos S; Pham TN; Tonetti DA; Tyner AL
Oncotarget; 2014 Aug; 5(15):6038-48. PubMed ID: 25153721
[TBL] [Abstract][Full Text] [Related]
11. Cancer-Associated Mutations in Breast Tumor Kinase/PTK6 Differentially Affect Enzyme Activity and Substrate Recognition.
Tsui T; Miller WT
Biochemistry; 2015 May; 54(20):3173-82. PubMed ID: 25940761
[TBL] [Abstract][Full Text] [Related]
12. Structural basis of the auto-inhibition mechanism of nonreceptor tyrosine kinase PTK6.
Ko S; Ahn KE; Lee YM; Ahn HC; Lee W
Biochem Biophys Res Commun; 2009 Jun; 384(2):236-42. PubMed ID: 19401189
[TBL] [Abstract][Full Text] [Related]
13. Crystal structure of the ALK (anaplastic lymphoma kinase) catalytic domain.
Lee CC; Jia Y; Li N; Sun X; Ng K; Ambing E; Gao MY; Hua S; Chen C; Kim S; Michellys PY; Lesley SA; Harris JL; Spraggon G
Biochem J; 2010 Sep; 430(3):425-37. PubMed ID: 20632993
[TBL] [Abstract][Full Text] [Related]
14. PTK6 inhibition promotes apoptosis of Lapatinib-resistant Her2(+) breast cancer cells by inducing Bim.
Park SH; Ito K; Olcott W; Katsyv I; Halstead-Nussloch G; Irie HY
Breast Cancer Res; 2015 Jun; 17(1):86. PubMed ID: 26084280
[TBL] [Abstract][Full Text] [Related]
15. Structural Insights into Pseudokinase Domains of Receptor Tyrosine Kinases.
Sheetz JB; Mathea S; Karvonen H; Malhotra K; Chatterjee D; Niininen W; Perttilä R; Preuss F; Suresh K; Stayrook SE; Tsutsui Y; Radhakrishnan R; Ungureanu D; Knapp S; Lemmon MA
Mol Cell; 2020 Aug; 79(3):390-405.e7. PubMed ID: 32619402
[TBL] [Abstract][Full Text] [Related]
16. The alternative splice variant of protein tyrosine kinase 6 negatively regulates growth and enhances PTK6-mediated inhibition of β-catenin.
Brauer PM; Zheng Y; Evans MD; Dominguez-Brauer C; Peehl DM; Tyner AL
PLoS One; 2011 Mar; 6(3):e14789. PubMed ID: 21479203
[TBL] [Abstract][Full Text] [Related]
17. Impact of protein tyrosine kinase 6 (PTK6) on human epidermal growth factor receptor (HER) signalling in breast cancer.
Ludyga N; Anastasov N; Gonzalez-Vasconcellos I; Ram M; Höfler H; Aubele M
Mol Biosyst; 2011 May; 7(5):1603-12. PubMed ID: 21380407
[TBL] [Abstract][Full Text] [Related]
18. Molecular Architecture of SF3b and Structural Consequences of Its Cancer-Related Mutations.
Cretu C; Schmitzová J; Ponce-Salvatierra A; Dybkov O; De Laurentiis EI; Sharma K; Will CL; Urlaub H; Lührmann R; Pena V
Mol Cell; 2016 Oct; 64(2):307-319. PubMed ID: 27720643
[TBL] [Abstract][Full Text] [Related]
19. Hsp90 rescues PTK6 from proteasomal degradation in breast cancer cells.
Kang SA; Cho HS; Yoon JB; Chung IK; Lee ST
Biochem J; 2012 Oct; 447(2):313-20. PubMed ID: 22849407
[TBL] [Abstract][Full Text] [Related]
20. Targeting protein tyrosine kinase 6 in cancer.
Gilic MB; Tyner AL
Biochim Biophys Acta Rev Cancer; 2020 Dec; 1874(2):188432. PubMed ID: 32956764
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]