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2. Determination of the role of injection site on the efficacy of intra-CSF enzyme replacement therapy in MPS IIIA mice. Beard H; Luck AJ; Hassiotis S; King B; Trim PJ; Snel MF; Hopwood JJ; Hemsley KM Mol Genet Metab; 2015 May; 115(1):33-40. PubMed ID: 25795516 [TBL] [Abstract][Full Text] [Related]
3. Low-dose, continuous enzyme replacement therapy ameliorates brain pathology in the neurodegenerative lysosomal disorder mucopolysaccharidosis type IIIA. King B; Hassiotis S; Rozaklis T; Beard H; Trim PJ; Snel MF; Hopwood JJ; Hemsley KM J Neurochem; 2016 May; 137(3):409-22. PubMed ID: 26762778 [TBL] [Abstract][Full Text] [Related]
4. Intracerebral injection of sulfamidase delays neuropathology in murine MPS-IIIA. Savas PS; Hemsley KM; Hopwood JJ Mol Genet Metab; 2004 Aug; 82(4):273-85. PubMed ID: 15308125 [TBL] [Abstract][Full Text] [Related]
6. Effect of cisternal sulfamidase delivery in MPS IIIA Huntaway dogs--a proof of principle study. Hemsley KM; Norman EJ; Crawley AC; Auclair D; King B; Fuller M; Lang DL; Dean CJ; Jolly RD; Hopwood JJ Mol Genet Metab; 2009 Dec; 98(4):383-92. PubMed ID: 19699666 [TBL] [Abstract][Full Text] [Related]
7. Slow, continuous enzyme replacement via spinal CSF in dogs with the paediatric-onset neurodegenerative disease, MPS IIIA. King B; Marshall NR; Hassiotis S; Trim PJ; Tucker J; Hattersley K; Snel MF; Jolly RD; Hopwood JJ; Hemsley KM J Inherit Metab Dis; 2017 May; 40(3):443-453. PubMed ID: 27832416 [TBL] [Abstract][Full Text] [Related]
8. Glycosaminoglycan levels and structure in a mucopolysaccharidosis IIIA mice and the effect of a highly secreted sulfamidase engineered to cross the blood-brain barrier. Maccari F; Sorrentino NC; Mantovani V; Galeotti F; Fraldi A; Volpi N Metab Brain Dis; 2017 Feb; 32(1):203-210. PubMed ID: 27585464 [TBL] [Abstract][Full Text] [Related]
9. Injection of recombinant human sulfamidase into the CSF via the cerebellomedullary cistern in MPS IIIA mice. Hemsley KM; King B; Hopwood JJ Mol Genet Metab; 2007 Mar; 90(3):313-28. PubMed ID: 17166757 [TBL] [Abstract][Full Text] [Related]
10. Enzyme-replacement therapy from birth delays the development of behavior and learning problems in mucopolysaccharidosis type IIIA mice. Gliddon BL; Hopwood JJ Pediatr Res; 2004 Jul; 56(1):65-72. PubMed ID: 15128919 [TBL] [Abstract][Full Text] [Related]
11. Evaluation of enzyme dose and dose-frequency in ameliorating substrate accumulation in MPS IIIA Huntaway dog brain. King B; Marshall N; Beard H; Hassiotis S; Trim PJ; Snel MF; Rozaklis T; Jolly RD; Hopwood JJ; Hemsley KM J Inherit Metab Dis; 2015 Mar; 38(2):341-50. PubMed ID: 25421091 [TBL] [Abstract][Full Text] [Related]
12. Effect of high dose, repeated intra-cerebrospinal fluid injection of sulphamidase on neuropathology in mucopolysaccharidosis type IIIA mice. Mader KM; Beard H; King BM; Hopwood JJ Genes Brain Behav; 2008 Oct; 7(7):740-53. PubMed ID: 18518922 [TBL] [Abstract][Full Text] [Related]
13. Impact of high-dose, chemically modified sulfamidase on pathology in a murine model of MPS IIIA. Rozaklis T; Beard H; Hassiotis S; Garcia AR; Tonini M; Luck A; Pan J; Lamsa JC; Hopwood JJ; Hemsley KM Exp Neurol; 2011 Jul; 230(1):123-30. PubMed ID: 21515264 [TBL] [Abstract][Full Text] [Related]
15. Correction of mucopolysaccharidosis type IIIA somatic and central nervous system pathology by lentiviral-mediated gene transfer. McIntyre C; Byers S; Anson DS J Gene Med; 2010 Sep; 12(9):717-28. PubMed ID: 20683858 [TBL] [Abstract][Full Text] [Related]
16. Correction of murine mucopolysaccharidosis type IIIA central nervous system pathology by intracerebroventricular lentiviral-mediated gene delivery. McIntyre C; Derrick-Roberts AL; Byers S; Anson DS J Gene Med; 2014; 16(11-12):374-87. PubMed ID: 25418946 [TBL] [Abstract][Full Text] [Related]
17. Validation of a heparan sulfate-derived disaccharide as a marker of accumulation in murine mucopolysaccharidosis type IIIA. King B; Savas P; Fuller M; Hopwood J; Hemsley K Mol Genet Metab; 2006 Feb; 87(2):107-12. PubMed ID: 16352454 [TBL] [Abstract][Full Text] [Related]
18. Functional correction of CNS lesions in an MPS-IIIA mouse model by intracerebral AAV-mediated delivery of sulfamidase and SUMF1 genes. Fraldi A; Hemsley K; Crawley A; Lombardi A; Lau A; Sutherland L; Auricchio A; Ballabio A; Hopwood JJ Hum Mol Genet; 2007 Nov; 16(22):2693-702. PubMed ID: 17725987 [TBL] [Abstract][Full Text] [Related]
19. Delivery of therapeutic protein for prevention of neurodegenerative changes: comparison of different CSF-delivery methods. Marshall NR; Hassiotis S; King B; Rozaklis T; Trim PJ; Duplock SK; Winner LK; Beard H; Snel MF; Jolly RD; Hopwood JJ; Hemsley KM Exp Neurol; 2015 Jan; 263():79-90. PubMed ID: 25246230 [TBL] [Abstract][Full Text] [Related]
20. Low-dose, continual enzyme delivery ameliorates some aspects of established brain disease in a mouse model of a childhood-onset neurodegenerative disorder. King B; Setford ML; Hassiotis S; Trim PJ; Duplock S; Tucker JN; Hattersley K; Snel MF; Hopwood JJ; Hemsley KM Exp Neurol; 2016 Apr; 278():11-21. PubMed ID: 26626972 [TBL] [Abstract][Full Text] [Related] [Next] [New Search]