480 related articles for article (PubMed ID: 27501246)
1. Proteasome inhibition for treatment of leishmaniasis, Chagas disease and sleeping sickness.
Khare S; Nagle AS; Biggart A; Lai YH; Liang F; Davis LC; Barnes SW; Mathison CJ; Myburgh E; Gao MY; Gillespie JR; Liu X; Tan JL; Stinson M; Rivera IC; Ballard J; Yeh V; Groessl T; Federe G; Koh HX; Venable JD; Bursulaya B; Shapiro M; Mishra PK; Spraggon G; Brock A; Mottram JC; Buckner FS; Rao SP; Wen BG; Walker JR; Tuntland T; Molteni V; Glynne RJ; Supek F
Nature; 2016 Sep; 537(7619):229-233. PubMed ID: 27501246
[TBL] [Abstract][Full Text] [Related]
2. Proteasome as a Drug Target in Trypanosomatid Diseases.
Silva ML; de Santiago-Silva KM; Fabris M; Camargo PG; de Lima Ferreira Bispo M
Curr Drug Targets; 2023; 24(10):781-789. PubMed ID: 37469152
[TBL] [Abstract][Full Text] [Related]
3. An Overview on Target-Based Drug Design against Kinetoplastid Protozoan Infections: Human African Trypanosomiasis, Chagas Disease and Leishmaniases.
Kourbeli V; Chontzopoulou E; Moschovou K; Pavlos D; Mavromoustakos T; Papanastasiou IP
Molecules; 2021 Jul; 26(15):. PubMed ID: 34361781
[TBL] [Abstract][Full Text] [Related]
4. Discovery and Characterization of Clinical Candidate LXE408 as a Kinetoplastid-Selective Proteasome Inhibitor for the Treatment of Leishmaniases.
Nagle A; Biggart A; Be C; Srinivas H; Hein A; Caridha D; Sciotti RJ; Pybus B; Kreishman-Deitrick M; Bursulaya B; Lai YH; Gao MY; Liang F; Mathison CJN; Liu X; Yeh V; Smith J; Lerario I; Xie Y; Chianelli D; Gibney M; Berman A; Chen YL; Jiricek J; Davis LC; Liu X; Ballard J; Khare S; Eggimann FK; Luneau A; Groessl T; Shapiro M; Richmond W; Johnson K; Rudewicz PJ; Rao SPS; Thompson C; Tuntland T; Spraggon G; Glynne RJ; Supek F; Wiesmann C; Molteni V
J Med Chem; 2020 Oct; 63(19):10773-10781. PubMed ID: 32667203
[TBL] [Abstract][Full Text] [Related]
5. The kinetoplastid chemotherapy revisited: current drugs, recent advances and future perspectives.
Castillo E; Dea-Ayuela MA; Bolás-Fernández F; Rangel M; González-Rosende ME
Curr Med Chem; 2010; 17(33):4027-51. PubMed ID: 20939823
[TBL] [Abstract][Full Text] [Related]
6. Sterol 14alpha-demethylase (CYP51) as a therapeutic target for human trypanosomiasis and leishmaniasis.
Lepesheva GI; Waterman MR
Curr Top Med Chem; 2011; 11(16):2060-71. PubMed ID: 21619513
[TBL] [Abstract][Full Text] [Related]
7. Infectious diseases. Overcoming neglect of kinetoplastid diseases.
Bilbe G
Science; 2015 May; 348(6238):974-6. PubMed ID: 26023124
[No Abstract] [Full Text] [Related]
8. Screening a Natural Product-Based Library against Kinetoplastid Parasites.
Zulfiqar B; Jones AJ; Sykes ML; Shelper TB; Davis RA; Avery VM
Molecules; 2017 Oct; 22(10):. PubMed ID: 29023425
[TBL] [Abstract][Full Text] [Related]
9. The Medicinal Chemistry of 3-nitro-1,2,4-triazoles: Focus on Infectious Diseases.
França RRF; Menozzi CAC; Castelo-Branco FS; Hoelz LVB; Boechat N
Curr Top Med Chem; 2021; 21(23):2072-2100. PubMed ID: 34477523
[TBL] [Abstract][Full Text] [Related]
10. Microbial proteasomes as drug targets.
Zhang H; Lin G
PLoS Pathog; 2021 Dec; 17(12):e1010058. PubMed ID: 34882737
[TBL] [Abstract][Full Text] [Related]
11. Leishmanicidal and Trypanocidal Activity of Metal Complexes with 1,2,4-Triazolo[1,5-a]pyrimidines: Insights on their Therapeutic Potential against Leishmaniasis and Chagas Disease.
Salas JM; Caballero AB; Esteban-Parra GM; Méndez-Arriaga JM
Curr Med Chem; 2017; 24(25):2796-2806. PubMed ID: 28521698
[TBL] [Abstract][Full Text] [Related]
12. Structure-Guided Design and Synthesis of a Pyridazinone Series of
Thomas MG; McGonagle K; Rowland P; Robinson DA; Dodd PG; Camino-Díaz I; Campbell L; Cantizani J; Castañeda P; Conn D; Craggs PD; Edwards D; Ferguson L; Fosberry A; Frame L; Goswami P; Hu X; Korczynska J; MacLean L; Martin J; Mutter N; Osuna-Cabello M; Paterson C; Peña I; Pinto EG; Pont C; Riley J; Shishikura Y; Simeons FRC; Stojanovski L; Thomas J; Wrobel K; Young RJ; Zmuda F; Zuccotto F; Read KD; Gilbert IH; Marco M; Miles TJ; Manzano P; De Rycker M
J Med Chem; 2023 Aug; 66(15):10413-10431. PubMed ID: 37506194
[TBL] [Abstract][Full Text] [Related]
13. Targeting calcium homeostasis as the therapy of Chagas' disease and leishmaniasis - a review.
Benaim B; Garcia CR
Trop Biomed; 2011 Dec; 28(3):471-81. PubMed ID: 22433874
[TBL] [Abstract][Full Text] [Related]
14. Drug discovery for the treatment of leishmaniasis, African sleeping sickness and Chagas disease.
Future Med Chem; 2013 Oct; 5(15):1709-18. PubMed ID: 24144408
[TBL] [Abstract][Full Text] [Related]
15. Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis.
Heby O; Persson L; Rentala M
Amino Acids; 2007 Aug; 33(2):359-66. PubMed ID: 17610127
[TBL] [Abstract][Full Text] [Related]
16. Overview of the role of kinetoplastid surface carbohydrates in infection and host cell invasion: prospects for therapeutic intervention.
Valente M; Castillo-Acosta VM; Vidal AE; González-Pacanowska D
Parasitology; 2019 Dec; 146(14):1743-1754. PubMed ID: 31603063
[TBL] [Abstract][Full Text] [Related]
17. Novel compounds to combat trypanosomatid infections: a medicinal chemical perspective.
González M; Cerecetto H
Expert Opin Ther Pat; 2011 May; 21(5):699-715. PubMed ID: 21428846
[TBL] [Abstract][Full Text] [Related]
18. Systematic study of 1,2,3-triazolyl sterols for the development of new drugs against parasitic Neglected Tropical Diseases.
Porta EOJ; Ballari MS; Carlucci R; Wilkinson S; Ma G; Tekwani BL; Labadie GR
Eur J Med Chem; 2023 Jun; 254():115378. PubMed ID: 37084599
[TBL] [Abstract][Full Text] [Related]
19. In vitro evaluation of arylsubstituted imidazoles derivatives as antiprotozoal agents and docking studies on sterol 14α-demethylase (CYP51) from Trypanosoma cruzi, Leishmania infantum, and Trypanosoma brucei.
Rojas Vargas JA; López AG; Pérez Y; Cos P; Froeyen M
Parasitol Res; 2019 May; 118(5):1533-1548. PubMed ID: 30903349
[TBL] [Abstract][Full Text] [Related]
20. Drug Discovery for Kinetoplastid Diseases: Future Directions.
Rao SPS; Barrett MP; Dranoff G; Faraday CJ; Gimpelewicz CR; Hailu A; Jones CL; Kelly JM; Lazdins-Helds JK; Mäser P; Mengel J; Mottram JC; Mowbray CE; Sacks DL; Scott P; Späth GF; Tarleton RL; Spector JM; Diagana TT
ACS Infect Dis; 2019 Feb; 5(2):152-157. PubMed ID: 30543391
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
