These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

120 related articles for article (PubMed ID: 27513093)

  • 1. Novel Pyrimidine Toll-like Receptor 7 and 8 Dual Agonists to Treat Hepatitis B Virus.
    McGowan D; Herschke F; Pauwels F; Stoops B; Last S; Pieters S; Scholliers A; Thoné T; Van Schoubroeck B; De Pooter D; Mostmans W; Khamlichi MD; Embrechts W; Dhuyvetter D; Smyej I; Arnoult E; Demin S; Borghys H; Fanning G; Vlach J; Raboisson P
    J Med Chem; 2016 Sep; 59(17):7936-49. PubMed ID: 27513093
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Identification and Optimization of Pyrrolo[3,2-d]pyrimidine Toll-like Receptor 7 (TLR7) Selective Agonists for the Treatment of Hepatitis B.
    McGowan DC; Herschke F; Pauwels F; Stoops B; Smyej I; Last S; Pieters S; Embrechts W; Khamlichi MD; Thoné T; Van Schoubroeck B; Mostmans W; Wuyts D; Verstappen D; Scholliers A; De Pooter D; Dhuyvetter D; Borghys H; Tuefferd M; Arnoult E; Hong J; Fanning G; Bollekens J; Urmaliya V; Teisman A; Horton H; Jonckers THM; Raboisson P
    J Med Chem; 2017 Jul; 60(14):6137-6151. PubMed ID: 28671847
    [TBL] [Abstract][Full Text] [Related]  

  • 3. 2,4-Diaminoquinazolines as Dual Toll-like Receptor (TLR) 7/8 Modulators for the Treatment of Hepatitis B Virus.
    Embrechts W; Herschke F; Pauwels F; Stoops B; Last S; Pieters S; Pande V; Pille G; Amssoms K; Smyej I; Dhuyvetter D; Scholliers A; Mostmans W; Van Dijck K; Van Schoubroeck B; Thone T; De Pooter D; Fanning G; Jonckers THM; Horton H; Raboisson P; McGowan D
    J Med Chem; 2018 Jul; 61(14):6236-6246. PubMed ID: 29965759
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Design and synthesis of tetrahydropyridopyrimidine based Toll-Like Receptor (TLR) 7/8 dual agonists.
    McGowan DC; Herschke F; Khamlichi MD; Rosauro ML; Benedicto SMP; Pauwels F; Stoops B; Pande V; Scholliers A; Van Schoubroeck B; Mostmans W; Van Dijck K; Thoné T; Horton H; Fanning G; Jonckers THM; Raboisson P
    Bioorg Med Chem Lett; 2018 Oct; 28(19):3216-3221. PubMed ID: 30143425
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Discovery of GS-9688 (Selgantolimod) as a Potent and Selective Oral Toll-Like Receptor 8 Agonist for the Treatment of Chronic Hepatitis B.
    Mackman RL; Mish M; Chin G; Perry JK; Appleby T; Aktoudianakis V; Metobo S; Pyun P; Niu C; Daffis S; Yu H; Zheng J; Villasenor AG; Zablocki J; Chamberlain J; Jin H; Lee G; Suekawa-Pirrone K; Santos R; Delaney WE; Fletcher SP
    J Med Chem; 2020 Sep; 63(18):10188-10203. PubMed ID: 32407112
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Design, synthesis, and biological evaluation of triazolo-pyrimidine derivatives as novel inhibitors of hepatitis B virus surface antigen (HBsAg) secretion.
    Yu W; Goddard C; Clearfield E; Mills C; Xiao T; Guo H; Morrey JD; Motter NE; Zhao K; Block TM; Cuconati A; Xu X
    J Med Chem; 2011 Aug; 54(16):5660-70. PubMed ID: 21786803
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Study on 2-arylthio-5-iodo pyrimidine derivatives as novel nonnucleoside inhibitors against hepatitis B virus DNA replication.
    Zhao J; Tu J; Fan N; Chen X; Lu F; Zhang Y; Zhang L; Tian C; Zhang Z; Liu J; Wang X
    Future Med Chem; 2016 May; 8(7):751-63. PubMed ID: 27172826
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery of selective 2,4-diaminoquinazoline toll-like receptor 7 (TLR 7) agonists.
    Pieters S; McGowan D; Herschke F; Pauwels F; Stoops B; Last S; Embrechts W; Scholliers A; Mostmans W; Van Dijck K; Van Schoubroeck B; Thoné T; De Pooter D; Fanning G; Rosauro ML; Khamlichi MD; Houpis I; Arnoult E; Jonckers THM; Raboisson P
    Bioorg Med Chem Lett; 2018 Feb; 28(4):711-719. PubMed ID: 29366653
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Identification and optimization of pteridinone Toll-like receptor 7 (TLR7) agonists for the oral treatment of viral hepatitis.
    Roethle PA; McFadden RM; Yang H; Hrvatin P; Hui H; Graupe M; Gallagher B; Chao J; Hesselgesser J; Duatschek P; Zheng J; Lu B; Tumas DB; Perry J; Halcomb RL
    J Med Chem; 2013 Sep; 56(18):7324-33. PubMed ID: 23961878
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Design and synthesis of aminothiazole based Hepatitis B Virus (HBV) capsid inhibitors.
    Pan T; Ding Y; Wu L; Liang L; He X; Li Q; Bai C; Zhang H
    Eur J Med Chem; 2019 Mar; 166():480-501. PubMed ID: 30739828
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Structure-Based Design of Highly Potent Toll-like Receptor 7/8 Dual Agonists for Cancer Immunotherapy.
    Wang Z; Gao Y; He L; Sun S; Xia T; Hu L; Yao L; Wang L; Li D; Shi H; Liao X
    J Med Chem; 2021 Jun; 64(11):7507-7532. PubMed ID: 34048243
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Synthesis and antiviral evaluation of novel heteroarylpyrimidines analogs as HBV capsid effectors.
    Boucle S; Lu X; Bassit L; Ozturk T; Russell OO; Amblard F; Coats SJ; Schinazi RF
    Bioorg Med Chem Lett; 2017 Feb; 27(4):904-910. PubMed ID: 28094179
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A new series of HAPs as anti-HBV agents targeting at capsid assembly.
    Yang XY; Xu XQ; Guan H; Wang LL; Wu Q; Zhao GM; Li S
    Bioorg Med Chem Lett; 2014 Sep; 24(17):4247-9. PubMed ID: 25127104
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Antiviral activity of various 1-(2'-deoxy-β-D-lyxofuranosyl), 1-(2'-fluoro-β-D-xylofuranosyl), 1-(3'-fluoro-β-D-arabinofuranosyl), and 2'-fluoro-2',3'-didehydro-2',3'-dideoxyribose pyrimidine nucleoside analogues against duck hepatitis B virus (DHBV) and human hepatitis B virus (HBV) replication.
    Srivastav NC; Shakya N; Mak M; Agrawal B; Tyrrell DL; Kumar R
    J Med Chem; 2010 Oct; 53(19):7156-66. PubMed ID: 20857959
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Identification of High-Potency Human TLR8 and Dual TLR7/TLR8 Agonists in Pyrimidine-2,4-diamines.
    Beesu M; Salyer AC; Brush MJ; Trautman KL; Hill JK; David SA
    J Med Chem; 2017 Mar; 60(5):2084-2098. PubMed ID: 28146629
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Recent advance of the hepatitis B virus inhibitors: a medicinal chemistry overview.
    Jia H; Rai D; Zhan P; Chen X; Jiang X; Liu X
    Future Med Chem; 2015; 7(5):587-607. PubMed ID: 25921400
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Administration of a dual toll-like receptor 7 and toll-like receptor 8 agonist protects against influenza in rats.
    Hammerbeck DM; Burleson GR; Schuller CJ; Vasilakos JP; Tomai M; Egging E; Cochran FR; Woulfe S; Miller RL
    Antiviral Res; 2007 Jan; 73(1):1-11. PubMed ID: 16959331
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Synthesis and SAR of pyridothiazole substituted pyrimidine derived HCV replication inhibitors.
    Girijavallabhan VM; Alvarez C; Bennett F; Chen L; Gavalas S; Huang Y; Kim SH; Kosinski A; Pinto P; Rizvi R; Rossman R; Shankar B; Tong L; Velazquez F; Venkatraman S; Verma VA; Kozlowski J; Shih NY; Piwinski JJ; MacCoss M; Kwong CD; Bansal N; Clark JL; Fowler AT; Kezar HS; Valiyaveettil J; Reynolds RC; Maddry JA; Ananthan S; Secrist JA; Li C; Chase R; Curry S; Huang HC; Tong X; Njoroge FG; Arasappan A
    Bioorg Med Chem Lett; 2012 Sep; 22(17):5652-7. PubMed ID: 22858143
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Inhibitory effects of metachromin A on hepatitis B virus production via impairment of the viral promoter activity.
    Yamashita A; Tamaki M; Kasai H; Tanaka T; Otoguro T; Ryo A; Maekawa S; Enomoto N; de Voogd NJ; Tanaka J; Moriishi K
    Antiviral Res; 2017 Sep; 145():136-145. PubMed ID: 28827084
    [TBL] [Abstract][Full Text] [Related]  

  • 20. 2-Arylthio-5-iodo pyrimidine derivatives as non-nucleoside HBV polymerase inhibitors.
    Wang J; Zhang L; Zhao J; Zhang Y; Liu Q; Tian C; Zhang Z; Liu J; Wang X
    Bioorg Med Chem; 2018 May; 26(8):1573-1578. PubMed ID: 29459146
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 6.