BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

197 related articles for article (PubMed ID: 27515131)

  • 1. The chemical class of quinazoline compounds provides a core structure for the design of anticytomegaloviral kinase inhibitors.
    Hutterer C; Hamilton S; Steingruber M; Zeitträger I; Bahsi H; Thuma N; Naing Z; Örfi Z; Örfi L; Socher E; Sticht H; Rawlinson W; Chou S; Haupt VJ; Marschall M
    Antiviral Res; 2016 Oct; 134():130-143. PubMed ID: 27515131
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Novel chemical class of pUL97 protein kinase-specific inhibitors with strong anticytomegaloviral activity.
    Herget T; Freitag M; Morbitzer M; Kupfer R; Stamminger T; Marschall M
    Antimicrob Agents Chemother; 2004 Nov; 48(11):4154-62. PubMed ID: 15504835
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Clinical development of letermovir and maribavir: Overview of human cytomegalovirus drug resistance.
    Piret J; Boivin G
    Antiviral Res; 2019 Mar; 163():91-105. PubMed ID: 30690043
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Antagonistic Relationship between Human Cytomegalovirus pUL27 and pUL97 Activities during Infection.
    Bigley TM; Reitsma JM; Terhune SS
    J Virol; 2015 Oct; 89(20):10230-46. PubMed ID: 26223645
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Novel cytomegalovirus-inhibitory compounds of the class pyrrolopyridines show a complex pattern of target binding that suggests an unusual mechanism of antiviral activity.
    Hahn F; Hutterer C; Henry C; Hamilton ST; Strojan H; Kraut A; Schulte U; Schütz M; Kohrt S; Wangen C; Pfizer J; Couté Y; Rawlinson WD; Strobl S; Marschall M
    Antiviral Res; 2018 Nov; 159():84-94. PubMed ID: 30268914
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Inhibitors of human cytomegalovirus replication drastically reduce the activity of the viral protein kinase pUL97.
    Marschall M; Stein-Gerlach M; Freitag M; Kupfer R; van den Bogaard M; Stamminger T
    J Gen Virol; 2001 Jun; 82(Pt 6):1439-1450. PubMed ID: 11369889
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Direct targeting of human cytomegalovirus protein kinase pUL97 by kinase inhibitors is a novel principle for antiviral therapy.
    Marschall M; Stein-Gerlach M; Freitag M; Kupfer R; van den Bogaard M; Stamminger T
    J Gen Virol; 2002 May; 83(Pt 5):1013-1023. PubMed ID: 11961255
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Differential properties of cytomegalovirus pUL97 kinase isoforms affect viral replication and maribavir susceptibility.
    Webel R; Hakki M; Prichard MN; Rawlinson WD; Marschall M; Chou S
    J Virol; 2014 May; 88(9):4776-85. PubMed ID: 24522923
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Protein kinase inhibitors of the quinazoline class exert anti-cytomegaloviral activity in vitro and in vivo.
    Schleiss M; Eickhoff J; Auerochs S; Leis M; Abele S; Rechter S; Choi Y; Anderson J; Scott G; Rawlinson W; Michel D; Ensminger S; Klebl B; Stamminger T; Marschall M
    Antiviral Res; 2008 Jul; 79(1):49-61. PubMed ID: 18329738
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Resistance of human cytomegalovirus to ganciclovir/valganciclovir: a comprehensive review of putative resistance pathways.
    Komatsu TE; Pikis A; Naeger LK; Harrington PR
    Antiviral Res; 2014 Jan; 101():12-25. PubMed ID: 24184129
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Combinatorial Drug Treatments Reveal Promising Anticytomegaloviral Profiles for Clinically Relevant Pharmaceutical Kinase Inhibitors (PKIs).
    Wild M; Kicuntod J; Seyler L; Wangen C; Bertzbach LD; Conradie AM; Kaufer BB; Wagner S; Michel D; Eickhoff J; Tsogoeva SB; Bäuerle T; Hahn F; Marschall M
    Int J Mol Sci; 2021 Jan; 22(2):. PubMed ID: 33430060
    [TBL] [Abstract][Full Text] [Related]  

  • 12. In vitro and in vivo activities of the novel anticytomegalovirus compound AIC246.
    Lischka P; Hewlett G; Wunberg T; Baumeister J; Paulsen D; Goldner T; Ruebsamen-Schaeff H; Zimmermann H
    Antimicrob Agents Chemother; 2010 Mar; 54(3):1290-7. PubMed ID: 20047911
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Antiviral inhibition targeting the HCMV kinase pUL97 requires pUL27-dependent degradation of Tip60 acetyltransferase and cell-cycle arrest.
    Reitsma JM; Savaryn JP; Faust K; Sato H; Halligan BD; Terhune SS
    Cell Host Microbe; 2011 Feb; 9(2):103-14. PubMed ID: 21320693
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis and characterization of novel quinazoline type inhibitors for mutant and wild-type EGFR and RICK kinases.
    Breza N; Pato J; Orfi L; Hegymegi-Barakonyi B; Banhegyi P; Varkondi E; Borbely G; Petak I; Keri G
    J Recept Signal Transduct Res; 2008; 28(4):361-73. PubMed ID: 18702009
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Cyclin-Dependent Kinases (CDKs) and the Human Cytomegalovirus-Encoded CDK Ortholog pUL97 Represent Highly Attractive Targets for Synergistic Drug Combinations.
    Wild M; Hahn F; Brückner N; Schütz M; Wangen C; Wagner S; Sommerer M; Strobl S; Marschall M
    Int J Mol Sci; 2022 Feb; 23(5):. PubMed ID: 35269635
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Indolocarbazoles exhibit strong antiviral activity against human cytomegalovirus and are potent inhibitors of the pUL97 protein kinase.
    Zimmermann A; Wilts H; Lenhardt M; Hahn M; Mertens T
    Antiviral Res; 2000 Oct; 48(1):49-60. PubMed ID: 11080540
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Inhibitors of dual-specificity tyrosine phosphorylation-regulated kinases (DYRK) exert a strong anti-herpesviral activity.
    Hutterer C; Milbradt J; Hamilton S; Zaja M; Leban J; Henry C; Vitt D; Steingruber M; Sonntag E; Zeitträger I; Bahsi H; Stamminger T; Rawlinson W; Strobl S; Marschall M
    Antiviral Res; 2017 Jul; 143():113-121. PubMed ID: 28400201
    [TBL] [Abstract][Full Text] [Related]  

  • 18. An in silico-designed flavone derivative, 6-fluoro-4'-hydroxy-3',5'-dimetoxyflavone, has a greater anti-human cytomegalovirus effect than ganciclovir in infected cells.
    Fujimoto KJ; Nema D; Ninomiya M; Koketsu M; Sadanari H; Takemoto M; Daikoku T; Murayama T
    Antiviral Res; 2018 Jun; 154():10-16. PubMed ID: 29559264
    [TBL] [Abstract][Full Text] [Related]  

  • 19. In vitro drug combination studies of Letermovir (AIC246, MK-8228) with approved anti-human cytomegalovirus (HCMV) and anti-HIV compounds in inhibition of HCMV and HIV replication.
    Wildum S; Zimmermann H; Lischka P
    Antimicrob Agents Chemother; 2015; 59(6):3140-8. PubMed ID: 25779572
    [TBL] [Abstract][Full Text] [Related]  

  • 20. The UL97 protein kinase of human cytomegalovirus and homologues in other herpesviruses: impact on virus and host.
    Michel D; Mertens T
    Biochim Biophys Acta; 2004 Mar; 1697(1-2):169-80. PubMed ID: 15023359
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.