334 related articles for article (PubMed ID: 27530298)
1. Differential 3-bromopyruvate inhibition of cytosolic and mitochondrial human serine hydroxymethyltransferase isoforms, key enzymes in cancer metabolic reprogramming.
Paiardini A; Tramonti A; Schirch D; Guiducci G; di Salvo ML; Fiascarelli A; Giorgi A; Maras B; Cutruzzolà F; Contestabile R
Biochim Biophys Acta; 2016 Nov; 1864(11):1506-17. PubMed ID: 27530298
[TBL] [Abstract][Full Text] [Related]
2. Human Cytosolic and Mitochondrial Serine Hydroxymethyltransferase Isoforms in Comparison: Full Kinetic Characterization and Substrate Inhibition Properties.
Tramonti A; Nardella C; di Salvo ML; Barile A; Cutruzzolà F; Contestabile R
Biochemistry; 2018 Dec; 57(51):6984-6996. PubMed ID: 30500180
[TBL] [Abstract][Full Text] [Related]
3. A pyrazolopyran derivative preferentially inhibits the activity of human cytosolic serine hydroxymethyltransferase and induces cell death in lung cancer cells.
Marani M; Paone A; Fiascarelli A; Macone A; Gargano M; Rinaldo S; Giardina G; Pontecorvi V; Koes D; McDermott L; Yang T; Paiardini A; Contestabile R; Cutruzzolà F
Oncotarget; 2016 Jan; 7(4):4570-83. PubMed ID: 26717037
[TBL] [Abstract][Full Text] [Related]
4. Differential inhibitory effect of a pyrazolopyran compound on human serine hydroxymethyltransferase-amino acid complexes.
Tramonti A; Paiardini A; Paone A; Bouzidi A; Giardina G; Guiducci G; Magnifico MC; Rinaldo S; McDermott L; Menendez JA; Contestabile R; Cutruzzolà F
Arch Biochem Biophys; 2018 Sep; 653():71-79. PubMed ID: 29991441
[TBL] [Abstract][Full Text] [Related]
5. Structural basis of inhibition of the human serine hydroxymethyltransferase SHMT2 by antifolate drugs.
Scaletti E; Jemth AS; Helleday T; Stenmark P
FEBS Lett; 2019 Jul; 593(14):1863-1873. PubMed ID: 31127856
[TBL] [Abstract][Full Text] [Related]
6. The moonlighting RNA-binding activity of cytosolic serine hydroxymethyltransferase contributes to control compartmentalization of serine metabolism.
Guiducci G; Paone A; Tramonti A; Giardina G; Rinaldo S; Bouzidi A; Magnifico MC; Marani M; Menendez JA; Fatica A; Macone A; Armaos A; Tartaglia GG; Contestabile R; Paiardini A; Cutruzzolà F
Nucleic Acids Res; 2019 May; 47(8):4240-4254. PubMed ID: 30809670
[TBL] [Abstract][Full Text] [Related]
7. How pyridoxal 5'-phosphate differentially regulates human cytosolic and mitochondrial serine hydroxymethyltransferase oligomeric state.
Giardina G; Brunotti P; Fiascarelli A; Cicalini A; Costa MG; Buckle AM; di Salvo ML; Giorgi A; Marani M; Paone A; Rinaldo S; Paiardini A; Contestabile R; Cutruzzolà F
FEBS J; 2015 Apr; 282(7):1225-41. PubMed ID: 25619277
[TBL] [Abstract][Full Text] [Related]
8.
Situ Y; Zhang J; Liao W; Liang Q; Lu L; Xu Q; Chen J; Lu X; Cui Y; Shao Z; Deng L
Front Biosci (Landmark Ed); 2023 Sep; 28(9):196. PubMed ID: 37796681
[TBL] [Abstract][Full Text] [Related]
9. Identification of three new compounds that directly target human serine hydroxymethyltransferase 2.
Han Y; He L; Qi Y; Zhao Y; Pan Y; Fang B; Li S; Zhang JZH; Zhang L
Chem Biol Drug Des; 2021 Feb; 97(2):221-230. PubMed ID: 32779873
[TBL] [Abstract][Full Text] [Related]
10. The catalytic activity of serine hydroxymethyltransferase is essential for de novo nuclear dTMP synthesis in lung cancer cells.
Giardina G; Paone A; Tramonti A; Lucchi R; Marani M; Magnifico MC; Bouzidi A; Pontecorvi V; Guiducci G; Zamparelli C; Rinaldo S; Paiardini A; Contestabile R; Cutruzzolà F
FEBS J; 2018 Sep; 285(17):3238-3253. PubMed ID: 30035852
[TBL] [Abstract][Full Text] [Related]
11. Deamidation of asparagine residues in a recombinant serine hydroxymethyltransferase.
di Salvo ML; Delle Fratte S; Maras B; Bossa F; Wright HT; Schirch V
Arch Biochem Biophys; 1999 Dec; 372(2):271-9. PubMed ID: 10600164
[TBL] [Abstract][Full Text] [Related]
12. Serine hydroxymethyltransferase isoforms are differentially inhibited by leucovorin: characterization and comparison of recombinant zebrafish serine hydroxymethyltransferases.
Chang WN; Tsai JN; Chen BH; Huang HS; Fu TF
Drug Metab Dispos; 2007 Nov; 35(11):2127-37. PubMed ID: 17664250
[TBL] [Abstract][Full Text] [Related]
13. Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-
Dekhne AS; Ning C; Nayeen MJ; Shah K; Kalpage H; Frühauf J; Wallace-Povirk A; O'Connor C; Hou Z; Kim S; Hüttemann M; Gangjee A; Matherly LH
Mol Pharmacol; 2020 Jan; 97(1):9-22. PubMed ID: 31707355
[TBL] [Abstract][Full Text] [Related]
14. Disruption of distal interactions of Arg 262 and of substrate binding to Ser 52 affect catalysis of sheep liver cytosolic serine hydroxymethyltransferase.
Jala VR; Ambili M; Prakash V; Rao NA; Savithri HS
Indian J Biochem Biophys; 2003 Aug; 40(4):226-37. PubMed ID: 22900314
[TBL] [Abstract][Full Text] [Related]
15. SHMT1 knockdown induces apoptosis in lung cancer cells by causing uracil misincorporation.
Paone A; Marani M; Fiascarelli A; Rinaldo S; Giardina G; Contestabile R; Paiardini A; Cutruzzolà F
Cell Death Dis; 2014 Nov; 5(11):e1525. PubMed ID: 25412303
[TBL] [Abstract][Full Text] [Related]
16. Arg-265: a critical residue of L.donovani cytosolic SHMT in maintaining the binding of THF and catalysis.
Gandhi S; Gaur N; Krishna S; Siddiqi MI; Saxena JK
Exp Parasitol; 2015 Feb; 149():16-23. PubMed ID: 25499510
[TBL] [Abstract][Full Text] [Related]
17. The function of arginine 363 as the substrate carboxyl-binding site in Escherichia coli serine hydroxymethyltransferase.
Delle Fratte S; Iurescia S; Angelaccio S; Bossa F; Schirch V
Eur J Biochem; 1994 Oct; 225(1):395-401. PubMed ID: 7925461
[TBL] [Abstract][Full Text] [Related]
18. Serine hydroxymethyltransferase 1 and 2: gene sequence variation and functional genomic characterization.
Hebbring SJ; Chai Y; Ji Y; Abo RP; Jenkins GD; Fridley B; Zhang J; Eckloff BW; Wieben ED; Weinshilboum RM
J Neurochem; 2012 Mar; 120(6):881-90. PubMed ID: 22220685
[TBL] [Abstract][Full Text] [Related]
19. The crystal structure of human cytosolic serine hydroxymethyltransferase: a target for cancer chemotherapy.
Renwick SB; Snell K; Baumann U
Structure; 1998 Sep; 6(9):1105-16. PubMed ID: 9753690
[TBL] [Abstract][Full Text] [Related]
20. Crystal structure at 2.4 A resolution of E. coli serine hydroxymethyltransferase in complex with glycine substrate and 5-formyl tetrahydrofolate.
Scarsdale JN; Radaev S; Kazanina G; Schirch V; Wright HT
J Mol Biol; 2000 Feb; 296(1):155-68. PubMed ID: 10656824
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]