BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

239 related articles for article (PubMed ID: 27533850)

  • 1. Two-Mechanism Model for the Interaction of Etoposide Quinone with Topoisomerase IIα.
    Gibson EG; King MM; Mercer SL; Deweese JE
    Chem Res Toxicol; 2016 Sep; 29(9):1541-8. PubMed ID: 27533850
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Mutation of cysteine residue 455 to alanine in human topoisomerase IIalpha confers hypersensitivity to quinones: enhancing DNA scission by closing the N-terminal protein gate.
    Bender RP; Osheroff N
    Chem Res Toxicol; 2007 Jun; 20(6):975-81. PubMed ID: 17516663
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Etoposide quinone is a redox-dependent topoisomerase II poison.
    Jacob DA; Mercer SL; Osheroff N; Deweese JE
    Biochemistry; 2011 Jun; 50(25):5660-7. PubMed ID: 21595477
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Catalytic core of human topoisomerase IIα: insights into enzyme-DNA interactions and drug mechanism.
    Lindsey RH; Pendleton M; Ashley RE; Mercer SL; Deweese JE; Osheroff N
    Biochemistry; 2014 Oct; 53(41):6595-602. PubMed ID: 25280269
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Quinone-induced enhancement of DNA cleavage by human topoisomerase IIalpha: adduction of cysteine residues 392 and 405.
    Bender RP; Ham AJ; Osheroff N
    Biochemistry; 2007 Mar; 46(10):2856-64. PubMed ID: 17298034
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Polychlorinated biphenyl quinone metabolites poison human topoisomerase IIalpha: altering enzyme function by blocking the N-terminal protein gate.
    Bender RP; Lehmler HJ; Robertson LW; Ludewig G; Osheroff N
    Biochemistry; 2006 Aug; 45(33):10140-52. PubMed ID: 16906772
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Etoposide quinone is a covalent poison of human topoisomerase IIβ.
    Smith NA; Byl JA; Mercer SL; Deweese JE; Osheroff N
    Biochemistry; 2014 May; 53(19):3229-36. PubMed ID: 24766193
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Etoposide metabolites enhance DNA topoisomerase II cleavage near leukemia-associated MLL translocation breakpoints.
    Lovett BD; Strumberg D; Blair IA; Pang S; Burden DA; Megonigal MD; Rappaport EF; Rebbeck TR; Osheroff N; Pommier YG; Felix CA
    Biochemistry; 2001 Feb; 40(5):1159-70. PubMed ID: 11170441
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Effects of Secondary Metabolites from the Fungus Septofusidium berolinense on DNA Cleavage Mediated by Human Topoisomerase IIα.
    Vann KR; Ekiz G; Zencir S; Bedir E; Topcu Z; Osheroff N
    Chem Res Toxicol; 2016 Mar; 29(3):415-20. PubMed ID: 26894873
    [TBL] [Abstract][Full Text] [Related]  

  • 10. HU-331 is a catalytic inhibitor of topoisomerase IIα.
    Regal KM; Mercer SL; Deweese JE
    Chem Res Toxicol; 2014 Dec; 27(12):2044-51. PubMed ID: 25409338
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Impact of the C-terminal domain of topoisomerase IIalpha on the DNA cleavage activity of the human enzyme.
    Dickey JS; Osheroff N
    Biochemistry; 2005 Aug; 44(34):11546-54. PubMed ID: 16114891
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Chinese hamster ovary cells resistant to the topoisomerase II catalytic inhibitor ICRF-159: a Tyr49Phe mutation confers high-level resistance to bisdioxopiperazines.
    Sehested M; Wessel I; Jensen LH; Holm B; Oliveri RS; Kenwrick S; Creighton AM; Nitiss JL; Jensen PB
    Cancer Res; 1998 Apr; 58(7):1460-8. PubMed ID: 9537249
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Contributions of the D-Ring to the activity of etoposide against human topoisomerase IIα: potential interactions with DNA in the ternary enzyme--drug--DNA complex.
    Pitts SL; Jablonksy MJ; Duca M; Dauzonne D; Monneret C; Arimondo PB; Anklin C; Graves DE; Osheroff N
    Biochemistry; 2011 Jun; 50(22):5058-66. PubMed ID: 21548574
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Synthesis and biological evaluation of C1-O-substituted-3-(3-butylamino-2-hydroxy-propoxy)-xanthen-9-one as topoisomerase IIα catalytic inhibitors.
    Park S; Hong E; Kwak SY; Jun KY; Lee ES; Kwon Y; Na Y
    Eur J Med Chem; 2016 Nov; 123():211-225. PubMed ID: 27484510
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Substituents on etoposide that interact with human topoisomerase IIalpha in the binary enzyme-drug complex: contributions to etoposide binding and activity.
    Bender RP; Jablonksy MJ; Shadid M; Romaine I; Dunlap N; Anklin C; Graves DE; Osheroff N
    Biochemistry; 2008 Apr; 47(15):4501-9. PubMed ID: 18355043
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Etoposide catechol is an oxidizable topoisomerase II poison.
    Jacob DA; Gibson EG; Mercer SL; Deweese JE
    Chem Res Toxicol; 2013 Aug; 26(8):1156-8. PubMed ID: 23863110
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Stimulation of topoisomerase II-mediated DNA cleavage by benzene metabolites.
    Lindsey RH; Bender RP; Osheroff N
    Chem Biol Interact; 2005 May; 153-154():197-205. PubMed ID: 15935817
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Modulation of drug sensitivity in yeast cells by the ATP-binding domain of human DNA topoisomerase IIalpha.
    Vilain N; Tsai-Pflugfelder M; Benoit A; Gasser SM; Leroy D
    Nucleic Acids Res; 2003 Oct; 31(19):5714-22. PubMed ID: 14500835
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The p53 tumor suppressor stimulates the catalytic activity of human topoisomerase IIalpha by enhancing the rate of ATP hydrolysis.
    Kwon Y; Shin BS; Chung IK
    J Biol Chem; 2000 Jun; 275(24):18503-10. PubMed ID: 10764786
    [TBL] [Abstract][Full Text] [Related]  

  • 20. A three-dimensional quantitative structure-activity relationship study of the inhibition of the ATPase activity and the strand passing catalytic activity of topoisomerase IIalpha by substituted purine analogs.
    Jensen LH; Liang H; Shoemaker R; Grauslund M; Sehested M; Hasinoff BB
    Mol Pharmacol; 2006 Nov; 70(5):1503-13. PubMed ID: 16880287
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.