BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

239 related articles for article (PubMed ID: 27533850)

  • 21. A two-drug model for etoposide action against human topoisomerase IIalpha.
    Bromberg KD; Burgin AB; Osheroff N
    J Biol Chem; 2003 Feb; 278(9):7406-12. PubMed ID: 12473657
    [TBL] [Abstract][Full Text] [Related]  

  • 22. Examination of the Impact of Copper(II) α-(N)-Heterocyclic Thiosemicarbazone Complexes on DNA Topoisomerase IIα.
    Wilson JT; Jiang X; McGill BC; Lisic EC; Deweese JE
    Chem Res Toxicol; 2016 Apr; 29(4):649-58. PubMed ID: 26982206
    [TBL] [Abstract][Full Text] [Related]  

  • 23. HU-331 and Oxidized Cannabidiol Act as Inhibitors of Human Topoisomerase IIα and β.
    Wilson JT; Fief CA; Jackson KD; Mercer SL; Deweese JE
    Chem Res Toxicol; 2018 Feb; 31(2):137-144. PubMed ID: 29272108
    [TBL] [Abstract][Full Text] [Related]  

  • 24. Human small cell lung cancer NYH cells selected for resistance to the bisdioxopiperazine topoisomerase II catalytic inhibitor ICRF-187 demonstrate a functional R162Q mutation in the Walker A consensus ATP binding domain of the alpha isoform.
    Wessel I; Jensen LH; Jensen PB; Falck J; Rose A; Roerth M; Nitiss JL; Sehested M
    Cancer Res; 1999 Jul; 59(14):3442-50. PubMed ID: 10416608
    [TBL] [Abstract][Full Text] [Related]  

  • 25. Interactions between the etoposide derivative F14512 and human type II topoisomerases: implications for the C4 spermine moiety in promoting enzyme-mediated DNA cleavage.
    Gentry AC; Pitts SL; Jablonsky MJ; Bailly C; Graves DE; Osheroff N
    Biochemistry; 2011 Apr; 50(15):3240-9. PubMed ID: 21413765
    [TBL] [Abstract][Full Text] [Related]  

  • 26. Cobalt enhances DNA cleavage mediated by human topoisomerase II alpha in vitro and in cultured cells.
    Baldwin EL; Byl JA; Osheroff N
    Biochemistry; 2004 Jan; 43(3):728-35. PubMed ID: 14730977
    [TBL] [Abstract][Full Text] [Related]  

  • 27. Differential cytotoxic pathways of topoisomerase I and II anticancer agents after overexpression of the E2F-1/DP-1 transcription factor complex.
    Hofland K; Petersen BO; Falck J; Helin K; Jensen PB; Sehested M
    Clin Cancer Res; 2000 Apr; 6(4):1488-97. PubMed ID: 10778981
    [TBL] [Abstract][Full Text] [Related]  

  • 28. The geometry of DNA supercoils modulates topoisomerase-mediated DNA cleavage and enzyme response to anticancer drugs.
    McClendon AK; Osheroff N
    Biochemistry; 2006 Mar; 45(9):3040-50. PubMed ID: 16503659
    [TBL] [Abstract][Full Text] [Related]  

  • 29. DNA topoisomerase II as the target for the anticancer drug TOP-53: mechanistic basis for drug action.
    Byl JA; Cline SD; Utsugi T; Kobunai T; Yamada Y; Osheroff N
    Biochemistry; 2001 Jan; 40(3):712-8. PubMed ID: 11170388
    [TBL] [Abstract][Full Text] [Related]  

  • 30. 1,2-Naphthoquinone as a Poison of Human Type II Topoisomerases.
    Collins JA; Osheroff N
    Chem Res Toxicol; 2021 Apr; 34(4):1082-1090. PubMed ID: 33760604
    [TBL] [Abstract][Full Text] [Related]  

  • 31. 4,6-Substituted-1,3,5-triazin-2(1H)-ones as monocyclic catalytic inhibitors of human DNA topoisomerase IIα targeting the ATP binding site.
    Pogorelčnik B; Janežič M; Sosič I; Gobec S; Solmajer T; Perdih A
    Bioorg Med Chem; 2015 Aug; 23(15):4218-4229. PubMed ID: 26183545
    [TBL] [Abstract][Full Text] [Related]  

  • 32. Novel trifluoromethylated 9-amino-3,4-dihydroacridin-1(2H)-ones act as covalent poisons of human topoisomerase IIα.
    Infante Lara L; Sledge A; Laradji A; Okoro CO; Osheroff N
    Bioorg Med Chem Lett; 2017 Feb; 27(3):586-589. PubMed ID: 27998679
    [TBL] [Abstract][Full Text] [Related]  

  • 33. Inhibition of the topoisomerase II-DNA cleavable complex by the ortho-quinone derivative of the antitumor drug etoposide (VP-16).
    Gantchev TG; Hunting DJ
    Biochem Biophys Res Commun; 1997 Aug; 237(1):24-7. PubMed ID: 9266822
    [TBL] [Abstract][Full Text] [Related]  

  • 34. Novel DNA topoisomerase IIα inhibitors from combined ligand- and structure-based virtual screening.
    Drwal MN; Marinello J; Manzo SG; Wakelin LP; Capranico G; Griffith R
    PLoS One; 2014; 9(12):e114904. PubMed ID: 25489853
    [TBL] [Abstract][Full Text] [Related]  

  • 35. N-acetyl-p-benzoquinone imine, the toxic metabolite of acetaminophen, is a topoisomerase II poison.
    Bender RP; Lindsey RH; Burden DA; Osheroff N
    Biochemistry; 2004 Mar; 43(12):3731-9. PubMed ID: 15035644
    [TBL] [Abstract][Full Text] [Related]  

  • 36. Inhibition of topoisomerase IIα sensitizes FaDu cells to ionizing radiation by diminishing DNA repair.
    Saleh EM
    Tumour Biol; 2015 Nov; 36(11):8985-92. PubMed ID: 26081617
    [TBL] [Abstract][Full Text] [Related]  

  • 37. DNA topoisomerases as targets for the anticancer drug TAS-103: primary cellular target and DNA cleavage enhancement.
    Byl JA; Fortune JM; Burden DA; Nitiss JL; Utsugi T; Yamada Y; Osheroff N
    Biochemistry; 1999 Nov; 38(47):15573-9. PubMed ID: 10569941
    [TBL] [Abstract][Full Text] [Related]  

  • 38. Novel xanthone-polyamine conjugates as catalytic inhibitors of human topoisomerase IIα.
    Minniti E; Byl JAW; Riccardi L; Sissi C; Rosini M; De Vivo M; Minarini A; Osheroff N
    Bioorg Med Chem Lett; 2017 Oct; 27(20):4687-4693. PubMed ID: 28919339
    [TBL] [Abstract][Full Text] [Related]  

  • 39. Using 3'-bridging phosphorothiolates to isolate the forward DNA cleavage reaction of human topoisomerase IIalpha.
    Deweese JE; Burgin AB; Osheroff N
    Biochemistry; 2008 Apr; 47(13):4129-40. PubMed ID: 18318502
    [TBL] [Abstract][Full Text] [Related]  

  • 40. Quinolone action against human topoisomerase IIalpha: stimulation of enzyme-mediated double-stranded DNA cleavage.
    Bromberg KD; Burgin AB; Osheroff N
    Biochemistry; 2003 Apr; 42(12):3393-8. PubMed ID: 12653542
    [TBL] [Abstract][Full Text] [Related]  

    [Previous]   [Next]    [New Search]
    of 12.