BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

438 related articles for article (PubMed ID: 27541578)

  • 1. Design, Synthesis, and Evaluation of Thiophene[3,2-d]pyrimidine Derivatives as HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Significantly Improved Drug Resistance Profiles.
    Kang D; Fang Z; Li Z; Huang B; Zhang H; Lu X; Xu H; Zhou Z; Ding X; Daelemans D; De Clercq E; Pannecouque C; Zhan P; Liu X
    J Med Chem; 2016 Sep; 59(17):7991-8007. PubMed ID: 27541578
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure-Based Optimization of Thiophene[3,2-d]pyrimidine Derivatives as Potent HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors with Improved Potency against Resistance-Associated Variants.
    Kang D; Fang Z; Huang B; Lu X; Zhang H; Xu H; Huo Z; Zhou Z; Yu Z; Meng Q; Wu G; Ding X; Tian Y; Daelemans D; De Clercq E; Pannecouque C; Zhan P; Liu X
    J Med Chem; 2017 May; 60(10):4424-4443. PubMed ID: 28481112
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Discovery of biphenyl-substituted diarylpyrimidines as non-nucleoside reverse transcriptase inhibitors with high potency against wild-type and mutant HIV-1.
    Jin K; Yin H; De Clercq E; Pannecouque C; Meng G; Chen F
    Eur J Med Chem; 2018 Feb; 145():726-734. PubMed ID: 29353724
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Discovery of novel diarylpyrimidines as potent HIV-1 NNRTIs by investigating the chemical space of a less explored "hydrophobic channel".
    Zhou Z; Liu T; Kang D; Huo Z; Wu G; Daelemans D; De Clercq E; Pannecouque C; Zhan P; Liu X
    Org Biomol Chem; 2018 Feb; 16(6):1014-1028. PubMed ID: 29349445
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Identification of novel potent HIV-1 inhibitors by exploiting the tolerant regions of the NNRTIs binding pocket.
    Sun Y; Kang D; Da F; Zhang T; Li P; Zhang B; De Clercq E; Pannecouque C; Zhan P; Liu X
    Eur J Med Chem; 2021 Mar; 214():113204. PubMed ID: 33567378
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Bioisosterism-based design and enantiomeric profiling of chiral hydroxyl-substituted biphenyl-diarylpyrimidine nonnucleoside HIV-1 reverse transcriptase inhibitors.
    Chen X; Ding L; Tao Y; Pannecouque C; De Clercq E; Zhuang C; Chen FE
    Eur J Med Chem; 2020 Sep; 202():112549. PubMed ID: 32712537
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Development of Novel Dihydrofuro[3,4-
    Kang D; Sun Y; Feng D; Gao S; Wang Z; Jing L; Zhang T; Jiang X; Lin H; De Clercq E; Pannecouque C; Zhan P; Liu X
    J Med Chem; 2022 Feb; 65(3):2458-2470. PubMed ID: 35061384
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Design, synthesis, and antiviral evaluation of novel hydrazone-substituted thiophene[3,2-d]pyrimidine derivatives as potent human immunodeficiency virus-1 inhibitors.
    Wang Z; Kang D; Chen M; Wu G; Feng D; Zhao T; Zhou Z; Huo Z; Jing L; Zuo X; Daelemans D; De Clercq E; Pannecouque C; Zhan P; Liu X
    Chem Biol Drug Des; 2018 Dec; 92(6):2009-2021. PubMed ID: 30079476
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Discovery of novel indolylarylsulfones as potent HIV-1 NNRTIs via structure-guided scaffold morphing.
    Zhao T; Meng Q; Kang D; Ji J; De Clercq E; Pannecouque C; Liu X; Zhan P
    Eur J Med Chem; 2019 Nov; 182():111619. PubMed ID: 31434039
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Conformational restriction design of thiophene-biphenyl-DAPY HIV-1 non-nucleoside reverse transcriptase inhibitors.
    Sang Y; Han S; Pannecouque C; De Clercq E; Zhuang C; Chen F
    Eur J Med Chem; 2019 Nov; 182():111603. PubMed ID: 31421633
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Fused heterocycles bearing bridgehead nitrogen as potent HIV-1 NNRTIs. Part 3: optimization of [1,2,4]triazolo[1,5-a]pyrimidine core via structure-based and physicochemical property-driven approaches.
    Huang B; Li C; Chen W; Liu T; Yu M; Fu L; Sun Y; Liu H; De Clercq E; Pannecouque C; Balzarini J; Zhan P; Liu X
    Eur J Med Chem; 2015 Mar; 92():754-65. PubMed ID: 25626145
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Identification of Dihydrofuro[3,4- d]pyrimidine Derivatives as Novel HIV-1 Non-Nucleoside Reverse Transcriptase Inhibitors with Promising Antiviral Activities and Desirable Physicochemical Properties.
    Kang D; Zhang H; Wang Z; Zhao T; Ginex T; Luque FJ; Yang Y; Wu G; Feng D; Wei F; Zhang J; De Clercq E; Pannecouque C; Chen CH; Lee KH; Murugan NA; Steitz TA; Zhan P; Liu X
    J Med Chem; 2019 Feb; 62(3):1484-1501. PubMed ID: 30624934
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synthesis and anti-human immunodeficiency virus activity of substituted ( o,o-difluorophenyl)-linked-pyrimidines as potent non-nucleoside reverse transcriptase inhibitors.
    Čechová L; Dejmek M; Baszczyňski O; Šaman D; Gao L; Hu E; Stepan G; Jansa P; Janeba Z; Šimon P
    Antivir Chem Chemother; 2019; 27():2040206619826265. PubMed ID: 30788976
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Design and synthesis of a new series of modified CH-diarylpyrimidines as drug-resistant HIV non-nucleoside reverse transcriptase inhibitors.
    Meng G; Liu Y; Zheng A; Chen F; Chen W; De Clercq E; Pannecouque C; Balzarini J
    Eur J Med Chem; 2014 Jul; 82():600-11. PubMed ID: 24952305
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Pharmacophore-fusing design of pyrimidine sulfonylacetanilides as potent non-nucleoside inhibitors of HIV-1 reverse transcriptase.
    Sang Y; Pannecouque C; De Clercq E; Zhuang C; Chen F
    Bioorg Chem; 2020 Mar; 96():103595. PubMed ID: 32006797
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Molecular design, synthesis and biological evaluation of BP-O-DAPY and O-DAPY derivatives as non-nucleoside HIV-1 reverse transcriptase inhibitors.
    Yang S; Pannecouque C; Daelemans D; Ma XD; Liu Y; Chen FE; De Clercq E
    Eur J Med Chem; 2013 Jul; 65():134-43. PubMed ID: 23707918
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Follow on-based optimization of the biphenyl-DAPYs as HIV-1 nonnucleoside reverse transcriptase inhibitors against the wild-type and mutant strains.
    Sang Y; Han S; Han S; Pannecouque C; De Clercq E; Zhuang C; Chen F
    Bioorg Chem; 2019 Aug; 89():102974. PubMed ID: 31102693
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Difluoromethylbenzoxazole pyrimidine thioether derivatives: a novel class of potent non-nucleoside HIV-1 reverse transcriptase inhibitors.
    Boyer J; Arnoult E; Médebielle M; Guillemont J; Unge J; Jochmans D
    J Med Chem; 2011 Dec; 54(23):7974-85. PubMed ID: 22017513
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Structure-guided design of novel biphenyl-quinazoline derivatives as potent non-nucleoside reverse transcriptase inhibitors featuring improved anti-resistance, selectivity, and solubility.
    Wang JS; Zhao KX; Zhang K; Pannecouque C; De Clercq E; Wang S; Chen FE
    Bioorg Chem; 2024 Jun; 147():107340. PubMed ID: 38593532
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Targeting the hydrophobic channel of NNIBP: discovery of novel 1,2,3-triazole-derived diarylpyrimidines as novel HIV-1 NNRTIs with high potency against wild-type and K103N mutant virus.
    Zhou Z; Liu T; Wu G; Kang D; Fu Z; Wang Z; De Clercq E; Pannecouque C; Zhan P; Liu X
    Org Biomol Chem; 2019 Mar; 17(12):3202-3217. PubMed ID: 30839042
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 22.