BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

267 related articles for article (PubMed ID: 27543075)

  • 1. Novel TDP2-ubiquitin interactions and their importance for the repair of topoisomerase II-mediated DNA damage.
    Rao T; Gao R; Takada S; Al Abo M; Chen X; Walters KJ; Pommier Y; Aihara H
    Nucleic Acids Res; 2016 Dec; 44(21):10201-10215. PubMed ID: 27543075
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Reversal of DNA damage induced Topoisomerase 2 DNA-protein crosslinks by Tdp2.
    Schellenberg MJ; Perera L; Strom CN; Waters CA; Monian B; Appel CD; Vilas CK; Williams JG; Ramsden DA; Williams RS
    Nucleic Acids Res; 2016 May; 44(8):3829-44. PubMed ID: 27060144
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Ubiquitin stimulated reversal of topoisomerase 2 DNA-protein crosslinks by TDP2.
    Schellenberg MJ; Appel CD; Riccio AA; Butler LR; Krahn JM; Liebermann JA; Cortés-Ledesma F; Williams RS
    Nucleic Acids Res; 2020 Jun; 48(11):6310-6325. PubMed ID: 32356875
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Depletion of tyrosyl DNA phosphodiesterase 2 activity enhances etoposide-mediated double-strand break formation and cell killing.
    Kont YS; Dutta A; Mallisetty A; Mathew J; Minas T; Kraus C; Dhopeshwarkar P; Kallakury B; Mitra S; Üren A; Adhikari S
    DNA Repair (Amst); 2016 Jul; 43():38-47. PubMed ID: 27235629
    [TBL] [Abstract][Full Text] [Related]  

  • 5. TDP2 promotes repair of topoisomerase I-mediated DNA damage in the absence of TDP1.
    Zeng Z; Sharma A; Ju L; Murai J; Umans L; Vermeire L; Pommier Y; Takeda S; Huylebroeck D; Caldecott KW; El-Khamisy SF
    Nucleic Acids Res; 2012 Sep; 40(17):8371-80. PubMed ID: 22740648
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Proteolytic degradation of topoisomerase II (Top2) enables the processing of Top2·DNA and Top2·RNA covalent complexes by tyrosyl-DNA-phosphodiesterase 2 (TDP2).
    Gao R; Schellenberg MJ; Huang SY; Abdelmalak M; Marchand C; Nitiss KC; Nitiss JL; Williams RS; Pommier Y
    J Biol Chem; 2014 Jun; 289(26):17960-9. PubMed ID: 24808172
    [TBL] [Abstract][Full Text] [Related]  

  • 7. TDP2-dependent non-homologous end-joining protects against topoisomerase II-induced DNA breaks and genome instability in cells and in vivo.
    Gómez-Herreros F; Romero-Granados R; Zeng Z; Alvarez-Quilón A; Quintero C; Ju L; Umans L; Vermeire L; Huylebroeck D; Caldecott KW; Cortés-Ledesma F
    PLoS Genet; 2013; 9(3):e1003226. PubMed ID: 23505375
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Effect of TDP2 on the Level of TOP2-DNA Complexes and SUMOylated TOP2-DNA Complexes.
    Lee KC; Swan RL; Sondka Z; Padget K; Cowell IG; Austin CA
    Int J Mol Sci; 2018 Jul; 19(7):. PubMed ID: 30011940
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Repair of trapped topoisomerase II covalent cleavage complexes: Novel proteasome-independent mechanisms.
    Tsuda M; Kitamasu K; Hosokawa S; Nakano T; Ide H
    Nucleosides Nucleotides Nucleic Acids; 2020; 39(1-3):170-184. PubMed ID: 31608820
    [TBL] [Abstract][Full Text] [Related]  

  • 10. TDP2 suppresses chromosomal translocations induced by DNA topoisomerase II during gene transcription.
    Gómez-Herreros F; Zagnoli-Vieira G; Ntai I; Martínez-Macías MI; Anderson RM; Herrero-Ruíz A; Caldecott KW
    Nat Commun; 2017 Aug; 8(1):233. PubMed ID: 28794467
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Biochemical characterization of human tyrosyl-DNA phosphodiesterase 2 (TDP2/TTRAP): a Mg(2+)/Mn(2+)-dependent phosphodiesterase specific for the repair of topoisomerase cleavage complexes.
    Gao R; Huang SY; Marchand C; Pommier Y
    J Biol Chem; 2012 Aug; 287(36):30842-52. PubMed ID: 22822062
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Tyrosyl-DNA phosphodiesterases: rescuing the genome from the risks of relaxation.
    Kawale AS; Povirk LF
    Nucleic Acids Res; 2018 Jan; 46(2):520-537. PubMed ID: 29216365
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Type II DNA Topoisomerases Cause Spontaneous Double-Strand Breaks in Genomic DNA.
    Morimoto S; Tsuda M; Bunch H; Sasanuma H; Austin C; Takeda S
    Genes (Basel); 2019 Oct; 10(11):. PubMed ID: 31671674
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Repair of topoisomerase 1-induced DNA damage by tyrosyl-DNA phosphodiesterase 2 (TDP2) is dependent on its magnesium binding.
    Shimizu N; Hamada Y; Morozumi R; Yamamoto J; Iwai S; Sugiyama KI; Ide H; Tsuda M
    J Biol Chem; 2023 Aug; 299(8):104988. PubMed ID: 37392847
    [TBL] [Abstract][Full Text] [Related]  

  • 15. A human 5'-tyrosyl DNA phosphodiesterase that repairs topoisomerase-mediated DNA damage.
    Cortes Ledesma F; El Khamisy SF; Zuma MC; Osborn K; Caldecott KW
    Nature; 2009 Oct; 461(7264):674-8. PubMed ID: 19794497
    [TBL] [Abstract][Full Text] [Related]  

  • 16. ZATT (ZNF451)-mediated resolution of topoisomerase 2 DNA-protein cross-links.
    Schellenberg MJ; Lieberman JA; Herrero-Ruiz A; Butler LR; Williams JG; Muñoz-Cabello AM; Mueller GA; London RE; Cortés-Ledesma F; Williams RS
    Science; 2017 Sep; 357(6358):1412-1416. PubMed ID: 28912134
    [TBL] [Abstract][Full Text] [Related]  

  • 17. TDP2/TTRAP is the major 5'-tyrosyl DNA phosphodiesterase activity in vertebrate cells and is critical for cellular resistance to topoisomerase II-induced DNA damage.
    Zeng Z; Cortés-Ledesma F; El Khamisy SF; Caldecott KW
    J Biol Chem; 2011 Jan; 286(1):403-9. PubMed ID: 21030584
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Physiological concentrations of glucocorticoids induce pathological DNA double-strand breaks.
    Akter S; Shimba A; Ikuta K; Mahmud MRA; Yamada S; Sasanuma H; Tsuda M; Sone M; Ago Y; Murai K; Tanaka H; Takeda S
    Genes Cells; 2023 Jan; 28(1):53-67. PubMed ID: 36415926
    [TBL] [Abstract][Full Text] [Related]  

  • 19. TDP2 protects transcription from abortive topoisomerase activity and is required for normal neural function.
    Gómez-Herreros F; Schuurs-Hoeijmakers JH; McCormack M; Greally MT; Rulten S; Romero-Granados R; Counihan TJ; Chaila E; Conroy J; Ennis S; Delanty N; Cortés-Ledesma F; de Brouwer AP; Cavalleri GL; El-Khamisy SF; de Vries BB; Caldecott KW
    Nat Genet; 2014 May; 46(5):516-21. PubMed ID: 24658003
    [TBL] [Abstract][Full Text] [Related]  

  • 20. ERK3 regulates TDP2-mediated DNA damage response and chemoresistance in lung cancer cells.
    Bian K; Muppani NR; Elkhadragy L; Wang W; Zhang C; Chen T; Jung S; Seternes OM; Long W
    Oncotarget; 2016 Feb; 7(6):6665-75. PubMed ID: 26701725
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.