829 related articles for article (PubMed ID: 27562556)
1. Editor's Highlight: Metformin Protects Against Acetaminophen Hepatotoxicity by Attenuation of Mitochondrial Oxidant Stress and Dysfunction.
Du K; Ramachandran A; Weemhoff JL; Chavan H; Xie Y; Krishnamurthy P; Jaeschke H
Toxicol Sci; 2016 Dec; 154(2):214-226. PubMed ID: 27562556
[TBL] [Abstract][Full Text] [Related]
2. Metformin ameliorates acetaminophen hepatotoxicity via Gadd45β-dependent regulation of JNK signaling in mice.
Kim YH; Hwang JH; Kim KS; Noh JR; Choi DH; Kim DK; Tadi S; Yim YH; Choi HS; Lee CH
J Hepatol; 2015 Jul; 63(1):75-82. PubMed ID: 25681557
[TBL] [Abstract][Full Text] [Related]
3. Inhibitor of apoptosis signal-regulating kinase 1 protects against acetaminophen-induced liver injury.
Xie Y; Ramachandran A; Breckenridge DG; Liles JT; Lebofsky M; Farhood A; Jaeschke H
Toxicol Appl Pharmacol; 2015 Jul; 286(1):1-9. PubMed ID: 25818599
[TBL] [Abstract][Full Text] [Related]
4. Mitochondria-targeted antioxidant Mito-Tempo protects against acetaminophen hepatotoxicity.
Du K; Farhood A; Jaeschke H
Arch Toxicol; 2017 Feb; 91(2):761-773. PubMed ID: 27002509
[TBL] [Abstract][Full Text] [Related]
5. Lower susceptibility of female mice to acetaminophen hepatotoxicity: Role of mitochondrial glutathione, oxidant stress and c-jun N-terminal kinase.
Du K; Williams CD; McGill MR; Jaeschke H
Toxicol Appl Pharmacol; 2014 Nov; 281(1):58-66. PubMed ID: 25218290
[TBL] [Abstract][Full Text] [Related]
6. Apoptosis-inducing factor modulates mitochondrial oxidant stress in acetaminophen hepatotoxicity.
Bajt ML; Ramachandran A; Yan HM; Lebofsky M; Farhood A; Lemasters JJ; Jaeschke H
Toxicol Sci; 2011 Aug; 122(2):598-605. PubMed ID: 21572097
[TBL] [Abstract][Full Text] [Related]
7. 4-Methylpyrazole protects against acetaminophen hepatotoxicity in mice and in primary human hepatocytes.
Akakpo JY; Ramachandran A; Kandel SE; Ni HM; Kumer SC; Rumack BH; Jaeschke H
Hum Exp Toxicol; 2018 Dec; 37(12):1310-1322. PubMed ID: 29739258
[TBL] [Abstract][Full Text] [Related]
8. The impact of partial manganese superoxide dismutase (SOD2)-deficiency on mitochondrial oxidant stress, DNA fragmentation and liver injury during acetaminophen hepatotoxicity.
Ramachandran A; Lebofsky M; Weinman SA; Jaeschke H
Toxicol Appl Pharmacol; 2011 Mar; 251(3):226-33. PubMed ID: 21241727
[TBL] [Abstract][Full Text] [Related]
9. c-Jun N-terminal kinase modulates oxidant stress and peroxynitrite formation independent of inducible nitric oxide synthase in acetaminophen hepatotoxicity.
Saito C; Lemasters JJ; Jaeschke H
Toxicol Appl Pharmacol; 2010 Jul; 246(1-2):8-17. PubMed ID: 20423716
[TBL] [Abstract][Full Text] [Related]
10. Purinergic receptor antagonist A438079 protects against acetaminophen-induced liver injury by inhibiting p450 isoenzymes, not by inflammasome activation.
Xie Y; Williams CD; McGill MR; Lebofsky M; Ramachandran A; Jaeschke H
Toxicol Sci; 2013 Jan; 131(1):325-35. PubMed ID: 22986947
[TBL] [Abstract][Full Text] [Related]
11. Low Dose Acetaminophen Induces Reversible Mitochondrial Dysfunction Associated with Transient c-Jun N-Terminal Kinase Activation in Mouse Liver.
Hu J; Ramshesh VK; McGill MR; Jaeschke H; Lemasters JJ
Toxicol Sci; 2016 Mar; 150(1):204-15. PubMed ID: 26721299
[TBL] [Abstract][Full Text] [Related]
12. Mitochondrial protein adduct and superoxide generation are prerequisites for early activation of c-jun N-terminal kinase within the cytosol after an acetaminophen overdose in mice.
Nguyen NT; Du K; Akakpo JY; Umbaugh DS; Jaeschke H; Ramachandran A
Toxicol Lett; 2021 Mar; 338():21-31. PubMed ID: 33290831
[TBL] [Abstract][Full Text] [Related]
13. Mangiferin ameliorates acetaminophen-induced hepatotoxicity through APAP-Cys and JNK modulation.
Chowdhury A; Lu J; Zhang R; Nabila J; Gao H; Wan Z; Adelusi Temitope I; Yin X; Sun Y
Biomed Pharmacother; 2019 Sep; 117():109097. PubMed ID: 31212128
[TBL] [Abstract][Full Text] [Related]
14. Hydrogen-rich water protects against acetaminophen-induced hepatotoxicity in mice.
Zhang JY; Song SD; Pang Q; Zhang RY; Wan Y; Yuan DW; Wu QF; Liu C
World J Gastroenterol; 2015 Apr; 21(14):4195-209. PubMed ID: 25892869
[TBL] [Abstract][Full Text] [Related]
15. The gap junction inhibitor 2-aminoethoxy-diphenyl-borate protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes and c-jun N-terminal kinase activation.
Du K; Williams CD; McGill MR; Xie Y; Farhood A; Vinken M; Jaeschke H
Toxicol Appl Pharmacol; 2013 Dec; 273(3):484-91. PubMed ID: 24070586
[TBL] [Abstract][Full Text] [Related]
16. Mitochondrial protein adducts formation and mitochondrial dysfunction during N-acetyl-m-aminophenol (AMAP)-induced hepatotoxicity in primary human hepatocytes.
Xie Y; McGill MR; Du K; Dorko K; Kumer SC; Schmitt TM; Ding WX; Jaeschke H
Toxicol Appl Pharmacol; 2015 Dec; 289(2):213-22. PubMed ID: 26431796
[TBL] [Abstract][Full Text] [Related]
17. Protein kinase C (PKC) participates in acetaminophen hepatotoxicity through c-jun-N-terminal kinase (JNK)-dependent and -independent signaling pathways.
Saberi B; Ybanez MD; Johnson HS; Gaarde WA; Han D; Kaplowitz N
Hepatology; 2014 Apr; 59(4):1543-1554. PubMed ID: 23873604
[TBL] [Abstract][Full Text] [Related]
18. Protection afforded by pre- or post-treatment with 4-phenylbutyrate against liver injury induced by acetaminophen overdose in mice.
Shimizu D; Ishitsuka Y; Miyata K; Tomishima Y; Kondo Y; Irikura M; Iwawaki T; Oike Y; Irie T
Pharmacol Res; 2014 Sep; 87():26-41. PubMed ID: 24951965
[TBL] [Abstract][Full Text] [Related]
19. The TGFβ1 Receptor Antagonist GW788388 Reduces JNK Activation and Protects Against Acetaminophen Hepatotoxicity in Mice.
McMillin M; Grant S; Frampton G; Petrescu AD; Williams E; Jefferson B; DeMorrow S
Toxicol Sci; 2019 May; 170(2):549-561. PubMed ID: 31132129
[TBL] [Abstract][Full Text] [Related]
20. Benzyl alcohol protects against acetaminophen hepatotoxicity by inhibiting cytochrome P450 enzymes but causes mitochondrial dysfunction and cell death at higher doses.
Du K; McGill MR; Xie Y; Jaeschke H
Food Chem Toxicol; 2015 Dec; 86():253-61. PubMed ID: 26522885
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
