362 related articles for article (PubMed ID: 27569045)
1. The Kinetic Stability of a Full-Length Antibody Light Chain Dimer Determines whether Endoproteolysis Can Release Amyloidogenic Variable Domains.
Morgan GJ; Kelly JW
J Mol Biol; 2016 Oct; 428(21):4280-4297. PubMed ID: 27569045
[TBL] [Abstract][Full Text] [Related]
2. Incomplete Refolding of Antibody Light Chains to Non-Native, Protease-Sensitive Conformations Leads to Aggregation: A Mechanism of Amyloidogenesis in Patients?
Morgan GJ; Usher GA; Kelly JW
Biochemistry; 2017 Dec; 56(50):6597-6614. PubMed ID: 29200282
[TBL] [Abstract][Full Text] [Related]
3. The critical role of the constant region in thermal stability and aggregation of amyloidogenic immunoglobulin light chain.
Klimtchuk ES; Gursky O; Patel RS; Laporte KL; Connors LH; Skinner M; Seldin DC
Biochemistry; 2010 Nov; 49(45):9848-57. PubMed ID: 20936823
[TBL] [Abstract][Full Text] [Related]
4. Protease-sensitive regions in amyloid light chains: what a common pattern of fragmentation across organs suggests about aggregation.
Mazzini G; Ricagno S; Caminito S; Rognoni P; Milani P; Nuvolone M; Basset M; Foli A; Russo R; Merlini G; Palladini G; Lavatelli F
FEBS J; 2022 Jan; 289(2):494-506. PubMed ID: 34482629
[TBL] [Abstract][Full Text] [Related]
5. Stabilization of amyloidogenic immunoglobulin light chains by small molecules.
Morgan GJ; Yan NL; Mortenson DE; Rennella E; Blundon JM; Gwin RM; Lin CY; Stanfield RL; Brown SJ; Rosen H; Spicer TP; Fernandez-Vega V; Merlini G; Kay LE; Wilson IA; Kelly JW
Proc Natl Acad Sci U S A; 2019 Apr; 116(17):8360-8369. PubMed ID: 30971495
[TBL] [Abstract][Full Text] [Related]
6. Role of domain interactions in the aggregation of full-length immunoglobulin light chains.
Rennella E; Morgan GJ; Kelly JW; Kay LE
Proc Natl Acad Sci U S A; 2019 Jan; 116(3):854-863. PubMed ID: 30598439
[TBL] [Abstract][Full Text] [Related]
7. Thermodynamic and fibril formation studies of full length immunoglobulin light chain AL-09 and its germline protein using scan rate dependent thermal unfolding.
Blancas-Mejía LM; Horn TJ; Marin-Argany M; Auton M; Tischer A; Ramirez-Alvarado M
Biophys Chem; 2015 Dec; 207():13-20. PubMed ID: 26263488
[TBL] [Abstract][Full Text] [Related]
8. Aggregation of Full-length Immunoglobulin Light Chains from Systemic Light Chain Amyloidosis (AL) Patients Is Remodeled by Epigallocatechin-3-gallate.
Andrich K; Hegenbart U; Kimmich C; Kedia N; Bergen HR; Schönland S; Wanker E; Bieschke J
J Biol Chem; 2017 Feb; 292(6):2328-2344. PubMed ID: 28031465
[TBL] [Abstract][Full Text] [Related]
9. A constant domain mutation in a patient-derived antibody light chain reveals principles of AL amyloidosis.
Rottenaicher GJ; Absmeier RM; Meier L; Zacharias M; Buchner J
Commun Biol; 2023 Feb; 6(1):209. PubMed ID: 36823438
[TBL] [Abstract][Full Text] [Related]
10. Fatal amyloid formation in a patient's antibody light chain is caused by a single point mutation.
Kazman P; Vielberg MT; Pulido Cendales MD; Hunziger L; Weber B; Hegenbart U; Zacharias M; Köhler R; Schönland S; Groll M; Buchner J
Elife; 2020 Mar; 9():. PubMed ID: 32151314
[TBL] [Abstract][Full Text] [Related]
11. Differential recruitment efficacy of patient-derived amyloidogenic and myeloma light chain proteins by synthetic fibrils-A metric for predicting amyloid propensity.
Martin EB; Williams A; Wooliver C; Heidel RE; Adams S; Dunlap J; Ramirez-Alvarado M; Blancas-Mejia LM; Lands RH; Kennel SJ; Wall JS
PLoS One; 2017; 12(3):e0174152. PubMed ID: 28350808
[TBL] [Abstract][Full Text] [Related]
12. Concurrent structural and biophysical traits link with immunoglobulin light chains amyloid propensity.
Oberti L; Rognoni P; Barbiroli A; Lavatelli F; Russo R; Maritan M; Palladini G; Bolognesi M; Merlini G; Ricagno S
Sci Rep; 2017 Dec; 7(1):16809. PubMed ID: 29196671
[TBL] [Abstract][Full Text] [Related]
13. Heat-induced native dimerization prevents amyloid formation by variable domain from immunoglobulin light-chain REI.
Nawata M; Tsutsumi H; Kobayashi Y; Unzai S; Mine S; Nakamura T; Uegaki K; Kamikubo H; Kataoka M; Hamada D
FEBS J; 2017 Sep; 284(18):3114-3127. PubMed ID: 28736891
[TBL] [Abstract][Full Text] [Related]
14. Mass spectrometry characterization of light chain fragmentation sites in cardiac AL amyloidosis: insights into the timing of proteolysis.
Lavatelli F; Mazzini G; Ricagno S; Iavarone F; Rognoni P; Milani P; Nuvolone M; Swuec P; Caminito S; Tasaki M; Chaves-Sanjuan A; Urbani A; Merlini G; Palladini G
J Biol Chem; 2020 Dec; 295(49):16572-16584. PubMed ID: 32952127
[TBL] [Abstract][Full Text] [Related]
15. Identification of two principal amyloid-driving segments in variable domains of Ig light chains in systemic light-chain amyloidosis.
Brumshtein B; Esswein SR; Sawaya MR; Rosenberg G; Ly AT; Landau M; Eisenberg DS
J Biol Chem; 2018 Dec; 293(51):19659-19671. PubMed ID: 30355736
[TBL] [Abstract][Full Text] [Related]
16. Mutations can cause light chains to be too stable or too unstable to form amyloid fibrils.
Marin-Argany M; Güell-Bosch J; Blancas-Mejía LM; Villegas S; Ramirez-Alvarado M
Protein Sci; 2015 Nov; 24(11):1829-40. PubMed ID: 26300552
[TBL] [Abstract][Full Text] [Related]
17. Domain Interactions Determine the Amyloidogenicity of Antibody Light Chain Mutants.
Weber B; Hora M; Kazman P; Pradhan T; Rührnößl F; Reif B; Buchner J
J Mol Biol; 2020 Nov; 432(23):6187-6199. PubMed ID: 33058870
[TBL] [Abstract][Full Text] [Related]
18. Amyloidogenic immunoglobulin light chain kinetic stabilizers comprising a simple urea linker module reveal a novel binding sub-site.
Yan NL; Nair R; Chu A; Wilson IA; Johnson KA; Morgan GJ; Kelly JW
Bioorg Med Chem Lett; 2022 Mar; 60():128571. PubMed ID: 35065233
[TBL] [Abstract][Full Text] [Related]
19. Kinetic evidence for multiple aggregation pathways in antibody light chain variable domains.
Wong S; West ME; Morgan GJ
Protein Sci; 2024 Mar; 33(3):e4871. PubMed ID: 38100259
[TBL] [Abstract][Full Text] [Related]
20. The Antibody Light-Chain Linker Regulates Domain Orientation and Amyloidogenicity.
Weber B; Hora M; Kazman P; Göbl C; Camilloni C; Reif B; Buchner J
J Mol Biol; 2018 Dec; 430(24):4925-4940. PubMed ID: 30414962
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
