BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

230 related articles for article (PubMed ID: 27573798)

  • 1. Spiro[pyrrolidine-3, 3´-oxindole] as potent anti-breast cancer compounds: Their design, synthesis, biological evaluation and cellular target identification.
    Hati S; Tripathy S; Dutta PK; Agarwal R; Srinivasan R; Singh A; Singh S; Sen S
    Sci Rep; 2016 Aug; 6():32213. PubMed ID: 27573798
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Spiro-oxindole derivative 5-chloro-4',5'-diphenyl-3'-(4-(2-(piperidin-1-yl) ethoxy) benzoyl) spiro[indoline-3,2'-pyrrolidin]-2-one triggers apoptosis in breast cancer cells via restoration of p53 function.
    Saxena R; Gupta G; Manohar M; Debnath U; Popli P; Prabhakar YS; Konwar R; Kumar S; Kumar A; Dwivedi A
    Int J Biochem Cell Biol; 2016 Jan; 70():105-17. PubMed ID: 26556313
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Design, synthesis and biological evaluation of novel steroidal spiro-oxindoles as potent antiproliferative agents.
    Yu B; Shi XJ; Qi PP; Yu DQ; Liu HM
    J Steroid Biochem Mol Biol; 2014 May; 141():121-34. PubMed ID: 24508598
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Organocatalytic Asymmetric Synthesis of Spiro-oxindole Piperidine Derivatives That Reduce Cancer Cell Proliferation by Inhibiting MDM2-p53 Interaction.
    Yang MC; Peng C; Huang H; Yang L; He XH; Huang W; Cui HL; He G; Han B
    Org Lett; 2017 Dec; 19(24):6752-6755. PubMed ID: 29210587
    [TBL] [Abstract][Full Text] [Related]  

  • 5. In vitro targeting of colon cancer cells using spiropyrazoline oxindoles.
    Nunes RC; Ribeiro CJA; Monteiro Â; Rodrigues CMP; Amaral JD; Santos MMM
    Eur J Med Chem; 2017 Oct; 139():168-179. PubMed ID: 28800455
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Design, synthesis, and biological evaluation of nitroisoxazole-containing spiro[pyrrolidin-oxindole] derivatives as novel glutathione peroxidase 4/mouse double minute 2 dual inhibitors that inhibit breast adenocarcinoma cell proliferation.
    Liu SJ; Zhao Q; Peng C; Mao Q; Wu F; Zhang FH; Feng QS; He G; Han B
    Eur J Med Chem; 2021 May; 217():113359. PubMed ID: 33725632
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Synthesis of new spirooxindole-pyrrolothiazole derivatives: Anti-cancer activity and molecular docking.
    Lotfy G; Said MM; El Ashry ESH; El Tamany ESH; Al-Dhfyan A; Abdel Aziz YM; Barakat A
    Bioorg Med Chem; 2017 Feb; 25(4):1514-1523. PubMed ID: 28126436
    [TBL] [Abstract][Full Text] [Related]  

  • 8. DNA Fragmentation, Cell Cycle Arrest, and Docking Study of Novel Bis Spiro-cyclic 2-oxindole of Pyrimido[4,5-b]quinoline-4,6-dione Derivatives Against Breast Carcinoma.
    Mohamed MF; Abdelmoniem AM; Elwahy AHM; Abdelhamid IA
    Curr Cancer Drug Targets; 2018; 18(4):372-381. PubMed ID: 28669339
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Synthesis of new thiazolo-pyrrolidine-(spirooxindole) tethered to 3-acylindole as anticancer agents.
    Islam MS; Ghawas HM; El-Senduny FF; Al-Majid AM; Elshaier YAMM; Badria FA; Barakat A
    Bioorg Chem; 2019 Feb; 82():423-430. PubMed ID: 30508794
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis, Biological Evaluation and In Silico Studies of Certain Oxindole-Indole Conjugates as Anticancer CDK Inhibitors.
    Al-Warhi T; El Kerdawy AM; Aljaeed N; Ismael OE; Ayyad RR; Eldehna WM; Abdel-Aziz HA; Al-Ansary GH
    Molecules; 2020 Apr; 25(9):. PubMed ID: 32349307
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Synthesis of novel spiropyrazoline oxindoles and evaluation of cytotoxicity in cancer cell lines.
    Monteiro Â; Gonçalves LM; Santos MM
    Eur J Med Chem; 2014 May; 79():266-72. PubMed ID: 24747063
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Design, synthesis and biological evaluation of novel antitumor spirotetrahydrothiopyran-oxindole derivatives as potent p53-MDM2 inhibitors.
    Ji C; Wang S; Chen S; He S; Jiang Y; Miao Z; Li J; Sheng C
    Bioorg Med Chem; 2017 Oct; 25(20):5268-5277. PubMed ID: 28797774
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Design of chemically stable, potent, and efficacious MDM2 inhibitors that exploit the retro-mannich ring-opening-cyclization reaction mechanism in spiro-oxindoles.
    Aguilar A; Sun W; Liu L; Lu J; McEachern D; Bernard D; Deschamps JR; Wang S
    J Med Chem; 2014 Dec; 57(24):10486-98. PubMed ID: 25496041
    [TBL] [Abstract][Full Text] [Related]  

  • 14. H2O-mediated isatin spiro-epoxide ring opening with NaCN: Synthesis of novel 3-tetrazolylmethyl-3-hydroxy-oxindole hybrids and their anticancer evaluation.
    Sharma P; Senwar KR; Jeengar MK; Reddy TS; Naidu VG; Kamal A; Shankaraiah N
    Eur J Med Chem; 2015 Nov; 104():11-24. PubMed ID: 26413726
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Design and Synthesis of New
    Farghaly TA; Pashameah RA; Bayazeed A; Al-Soliemy AM; Alsaedi AMR; Harras MF
    Med Chem; 2024; 20(1):63-77. PubMed ID: 37723960
    [TBL] [Abstract][Full Text] [Related]  

  • 16. A Facile One-Pot Construction of Succinimide-Fused Spiro[Pyrrolidine-2,3'-Oxindoles] via 1,3-Dipolar Cycloaddition Involving 3-Amino Oxindoles and Maleimides.
    Jin L; Liang F
    Molecules; 2018 Mar; 23(3):. PubMed ID: 29510590
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Fe
    Maddela S; Makula A; Galigniana MD; Parambi DGT; Federicci F; Mazaira G; Hendawy OM; Dev S; Mathew GE; Mathew B
    Arch Pharm (Weinheim); 2019 Jan; 352(1):e1800174. PubMed ID: 30485473
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Facile and diastereoselective synthesis of 3,2'-spiropyrrolidine-oxindoles derivatives, their molecular docking and antiproliferative activities.
    Kathirvelan D; Haribabu J; Reddy BS; Balachandran C; Duraipandiyan V
    Bioorg Med Chem Lett; 2015 Jan; 25(2):389-99. PubMed ID: 25435149
    [TBL] [Abstract][Full Text] [Related]  

  • 19. One-pot three-component synthesis of novel spirooxindoles with potential cytotoxic activity against triple-negative breast cancer MDA-MB-231 cells.
    Eldehna WM; El-Naggar DH; Hamed AR; Ibrahim HS; Ghabbour HA; Abdel-Aziz HA
    J Enzyme Inhib Med Chem; 2018 Dec; 33(1):309-318. PubMed ID: 29281924
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Discovery of new LXRβ agonists as glioblastoma inhibitors.
    Chen H; Chen Z; Zhang Z; Li Y; Zhang S; Jiang F; Wei J; Ding P; Zhou H; Gu Q; Xu J
    Eur J Med Chem; 2020 May; 194():112240. PubMed ID: 32248003
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 12.