BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

203 related articles for article (PubMed ID: 27576689)

  • 1. Effects of Hinge-region Natural Polymorphisms on Human Immunodeficiency Virus-Type 1 Protease Structure, Dynamics, and Drug Pressure Evolution.
    Liu Z; Huang X; Hu L; Pham L; Poole KM; Tang Y; Mahon BP; Tang W; Li K; Goldfarb NE; Dunn BM; McKenna R; Fanucci GE
    J Biol Chem; 2016 Oct; 291(43):22741-22756. PubMed ID: 27576689
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structural insights into the South African HIV-1 subtype C protease: impact of hinge region dynamics and flap flexibility in drug resistance.
    Naicker P; Achilonu I; Fanucchi S; Fernandes M; Ibrahim MA; Dirr HW; Soliman ME; Sayed Y
    J Biomol Struct Dyn; 2013 Dec; 31(12):1370-80. PubMed ID: 23140382
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structural Studies of a Rationally Selected Multi-Drug Resistant HIV-1 Protease Reveal Synergistic Effect of Distal Mutations on Flap Dynamics.
    Agniswamy J; Louis JM; Roche J; Harrison RW; Weber IT
    PLoS One; 2016; 11(12):e0168616. PubMed ID: 27992544
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Molecular dynamics and ligand docking of a hinge region variant of South African HIV-1 subtype C protease.
    Zondagh J; Balakrishnan V; Achilonu I; Dirr HW; Sayed Y
    J Mol Graph Model; 2018 Jun; 82():1-11. PubMed ID: 29625416
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The role of select subtype polymorphisms on HIV-1 protease conformational sampling and dynamics.
    Huang X; Britto MD; Kear-Scott JL; Boone CD; Rocca JR; Simmerling C; Mckenna R; Bieri M; Gooley PR; Dunn BM; Fanucci GE
    J Biol Chem; 2014 Jun; 289(24):17203-14. PubMed ID: 24742668
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Impact on replicative fitness of the G48E substitution in the protease of HIV-1: an in vitro and in silico evaluation.
    Zimmer JM; Roman F; Lambert C; Jonckheer A; Vazquez A; Plesséria JM; Servais JY; Covens K; Weber J; Van Laethem K; Schmit JC; Vandamme AM; Quinones-Mateu ME; De Maeyer M
    J Acquir Immune Defic Syndr; 2008 Jul; 48(3):255-62. PubMed ID: 18545158
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structural studies on molecular mechanisms of Nelfinavir resistance caused by non-active site mutation V77I in HIV-1 protease.
    Gupta A; Jamal S; Goyal S; Jain R; Wahi D; Grover A
    BMC Bioinformatics; 2015; 16 Suppl 19(Suppl 19):S10. PubMed ID: 26695135
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Elucidating a relationship between conformational sampling and drug resistance in HIV-1 protease.
    de Vera IM; Smith AN; Dancel MC; Huang X; Dunn BM; Fanucci GE
    Biochemistry; 2013 May; 52(19):3278-88. PubMed ID: 23566104
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Pulsed EPR characterization of HIV-1 protease conformational sampling and inhibitor-induced population shifts.
    Liu Z; Casey TM; Blackburn ME; Huang X; Pham L; de Vera IM; Carter JD; Kear-Scott JL; Veloro AM; Galiano L; Fanucci GE
    Phys Chem Chem Phys; 2016 Feb; 18(8):5819-31. PubMed ID: 26489725
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Amplification of the effects of drug resistance mutations by background polymorphisms in HIV-1 protease from African subtypes.
    Velazquez-Campoy A; Vega S; Freire E
    Biochemistry; 2002 Jul; 41(27):8613-9. PubMed ID: 12093278
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Structural basis and distal effects of Gag substrate coevolution in drug resistance to HIV-1 protease.
    Özen A; Lin KH; Kurt Yilmaz N; Schiffer CA
    Proc Natl Acad Sci U S A; 2014 Nov; 111(45):15993-8. PubMed ID: 25355911
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Natural Polymorphisms D60E and I62V Stabilize a Closed Conformation in HIV-1 Protease in the Absence of an Inhibitor or Substrate.
    Tran TT; Fanucci GE
    Viruses; 2024 Feb; 16(2):. PubMed ID: 38400012
    [TBL] [Abstract][Full Text] [Related]  

  • 13. HIV Protease Hinge Region Insertions at Codon 38 Affect Enzyme Kinetics, Conformational Stability and Dynamics.
    Sheik Ismail Z; Worth R; Mosebi S; Sayed Y
    Protein J; 2023 Oct; 42(5):490-501. PubMed ID: 37421557
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Effects of PRE and POST therapy drug-pressure selected mutations on HIV-1 protease conformational sampling.
    Carter JD; Gonzales EG; Huang X; Smith AN; de Vera IM; D'Amore PW; Rocca JR; Goodenow MM; Dunn BM; Fanucci GE
    FEBS Lett; 2014 Aug; 588(17):3123-8. PubMed ID: 24983495
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Conformational landscape of non-B variants of HIV-1 protease: A pulsed EPR study.
    Tran TT; Liu Z; Fanucci GE
    Biochem Biophys Res Commun; 2020 Nov; 532(2):219-224. PubMed ID: 32863004
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Darunavir-Resistant HIV-1 Protease Constructs Uphold a Conformational Selection Hypothesis for Drug Resistance.
    Liu Z; Tran TT; Pham L; Hu L; Bentz K; Savin DA; Fanucci GE
    Viruses; 2020 Nov; 12(11):. PubMed ID: 33171603
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structural basis of drug resistance by genetic variants of HIV type 1 clade c protease from India.
    Kandathil AJ; Joseph AP; Kannangai R; Srinivasan N; Abraham OC; Pulimood SA; Sridharan G
    AIDS Res Hum Retroviruses; 2009 May; 25(5):511-9. PubMed ID: 19400736
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Conformational variation of an extreme drug resistant mutant of HIV protease.
    Shen CH; Chang YC; Agniswamy J; Harrison RW; Weber IT
    J Mol Graph Model; 2015 Nov; 62():87-96. PubMed ID: 26397743
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Multi-drug resistance profile of PR20 HIV-1 protease is attributed to distorted conformational and drug binding landscape: molecular dynamics insights.
    Chetty S; Bhakat S; Martin AJ; Soliman ME
    J Biomol Struct Dyn; 2016; 34(1):135-51. PubMed ID: 25671669
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Crystal structures of a multidrug-resistant human immunodeficiency virus type 1 protease reveal an expanded active-site cavity.
    Logsdon BC; Vickrey JF; Martin P; Proteasa G; Koepke JI; Terlecky SR; Wawrzak Z; Winters MA; Merigan TC; Kovari LC
    J Virol; 2004 Mar; 78(6):3123-32. PubMed ID: 14990731
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.