325 related articles for article (PubMed ID: 27597642)
21. Synthesis and structure-activity relationship studies of 1,3-diarylprop-2-yn-1-ones: dual inhibitors of cyclooxygenases and lipoxygenases.
Rao PN; Chen QH; Knaus EE
J Med Chem; 2006 Mar; 49(5):1668-83. PubMed ID: 16509583
[TBL] [Abstract][Full Text] [Related]
22. ER-34122, a novel dual 5-lipoxygenase/cyclooxygenase inhibitor with potent anti-inflammatory activity in an arachidonic acid-induced ear inflammation model.
Horizoe T; Nagakura N; Chiba K; Shirota H; Shinoda M; Kobayashi N; Numata H; Okamoto Y; Kobayashi S
Inflamm Res; 1998 Oct; 47(10):375-83. PubMed ID: 9831321
[TBL] [Abstract][Full Text] [Related]
23. Conjugation of 4-aminosalicylate with thiazolinones afforded non-cytotoxic potent in vitro and in vivo anti-inflammatory hybrids.
Abdu-Allah HHM; Abdelmoez AAB; Tarazi H; El-Shorbagi AA; El-Awady R
Bioorg Chem; 2020 Jan; 94():103378. PubMed ID: 31677858
[TBL] [Abstract][Full Text] [Related]
24. Synthesis, biological evaluation and docking study of 1,3,4-thiadiazole-thiazolidinone hybrids as anti-inflammatory agents with dual inhibition of COX-2 and 15-LOX.
Omar YM; Abdu-Allah HHM; Abdel-Moty SG
Bioorg Chem; 2018 Oct; 80():461-471. PubMed ID: 29986191
[TBL] [Abstract][Full Text] [Related]
25. Dual synergistic inhibition of COX and LOX by potential chemicals from Indian daily spices investigated through detailed computational studies.
Rudrapal M; Eltayeb WA; Rakshit G; El-Arabey AA; Khan J; Aldosari SM; Alshehri B; Abdalla M
Sci Rep; 2023 May; 13(1):8656. PubMed ID: 37244921
[TBL] [Abstract][Full Text] [Related]
26. DuCLOX-2/5 inhibition: a promising target for cancer chemoprevention.
Gautam S; Roy S; Ansari MN; Saeedan AS; Saraf SA; Kaithwas G
Breast Cancer; 2017 Mar; 24(2):180-190. PubMed ID: 27558792
[TBL] [Abstract][Full Text] [Related]
27. The anti-inflammatory effects of Yunnan Baiyao are involved in regulation of the phospholipase A2/arachidonic acid metabolites pathways in acute inflammation rat model.
Ren X; Zhang M; Chen L; Zhang W; Huang Y; Luo H; Li L; He H
Mol Med Rep; 2017 Oct; 16(4):4045-4053. PubMed ID: 28765972
[TBL] [Abstract][Full Text] [Related]
28. Benzimidazole scaffold based hybrid molecules for various inflammatory targets: Synthesis and evaluation.
Kaur G; Silakari O
Bioorg Chem; 2018 Oct; 80():24-35. PubMed ID: 29864685
[TBL] [Abstract][Full Text] [Related]
29. Identification and development of thiazole leads as COX-2/5-LOX inhibitors through in-vitro and in-vivo biological evaluation for anti-inflammatory activity.
Jacob P J; Manju SL
Bioorg Chem; 2020 Jul; 100():103882. PubMed ID: 32361295
[TBL] [Abstract][Full Text] [Related]
30. Exploration of binding site pattern in arachidonic acid metabolizing enzymes, Cyclooxygenases and Lipoxygenases.
Reddy KK; Vidya Rajan VK; Gupta A; Aparoy P; Reddanna P
BMC Res Notes; 2015 Apr; 8():152. PubMed ID: 25886468
[TBL] [Abstract][Full Text] [Related]
31. Inhibitors of prostaglandin synthesis inhibit human prostate tumor cell invasiveness and reduce the release of matrix metalloproteinases.
Attiga FA; Fernandez PM; Weeraratna AT; Manyak MJ; Patierno SR
Cancer Res; 2000 Aug; 60(16):4629-37. PubMed ID: 10969817
[TBL] [Abstract][Full Text] [Related]
32. Involvement of eicosanoids in the pathogenesis of pancreatic cancer: the roles of cyclooxygenase-2 and 5-lipoxygenase.
Knab LM; Grippo PJ; Bentrem DJ
World J Gastroenterol; 2014 Aug; 20(31):10729-39. PubMed ID: 25152576
[TBL] [Abstract][Full Text] [Related]
33. Two-pronged approach to anti-inflammatory therapy through the modulation of the arachidonic acid cascade.
Sala A; Proschak E; Steinhilber D; Rovati GE
Biochem Pharmacol; 2018 Dec; 158():161-173. PubMed ID: 30315753
[TBL] [Abstract][Full Text] [Related]
34. Tailoring the substitution pattern of Pyrrolidine-2,5-dione for discovery of new structural template for dual COX/LOX inhibition.
Sadiq A; Mahnashi MH; Alyami BA; Alqahtani YS; Alqarni AO; Rashid U
Bioorg Chem; 2021 Jul; 112():104969. PubMed ID: 34023639
[TBL] [Abstract][Full Text] [Related]
35. Characterization of prostaglandin E2 generation through the cyclooxygenase (COX)-2 pathway in human neutrophils.
St-Onge M; Flamand N; Biarc J; Picard S; Bouchard L; Dussault AA; Laflamme C; James MJ; Caughey GE; Cleland LG; Borgeat P; Pouliot M
Biochim Biophys Acta; 2007 Sep; 1771(9):1235-45. PubMed ID: 17643350
[TBL] [Abstract][Full Text] [Related]
36. Treatment with either COX-2 inhibitor or 5-LOX inhibitor causes no compensation between COX-2 pathway and 5-LOX pathway in chronic aluminum overload-induced liver injury in rats.
Xia H; He Q; Wang H; Wang Y; Yang Y; Li Y; Zhang J; Chen Z; Yang J
Fundam Clin Pharmacol; 2019 Oct; 33(5):535-543. PubMed ID: 30903708
[TBL] [Abstract][Full Text] [Related]
37. 12-HETE is a regulator of PGE
Moreira V; Gutiérrez JM; Lomonte B; Vinolo MAR; Curi R; Lambeau G; Teixeira C
Chem Biol Interact; 2020 Feb; 317():108903. PubMed ID: 31811862
[TBL] [Abstract][Full Text] [Related]
38. New approaches to the modulation of the cyclooxygenase-2 and 5-lipoxygenase pathways.
González-Périz A; Clària J
Curr Top Med Chem; 2007; 7(3):297-309. PubMed ID: 17305572
[TBL] [Abstract][Full Text] [Related]
39. 5-LOX inhibitor modulates the inflammatory responses provoked by Helicobacter pylori infection.
Park S; Han SU; Lee KM; Park KH; Cho SW; Hahm KB
Helicobacter; 2007 Feb; 12(1):49-58. PubMed ID: 17241301
[TBL] [Abstract][Full Text] [Related]
40. Evaluation of anti-inflammatory and immunomodulatory effects of Premna integrifolia extracts and assay-guided isolation of a COX-2/5-LOX dual inhibitor.
Azad R; Babu NK; Gupta AD; Reddanna P
Fitoterapia; 2018 Nov; 131():189-199. PubMed ID: 30339925
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]