These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

168 related articles for article (PubMed ID: 27605113)

  • 1. High-Resolution Snapshots of Proteasome Inhibitors in Action Revise Inhibition Paradigms and Inspire Next-Generation Inhibitor Design.
    Carmony K; Lee W; Kim KB
    Chembiochem; 2016 Nov; 17(22):2115-2117. PubMed ID: 27605113
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The inhibition mechanism of human 20S proteasomes enables next-generation inhibitor design.
    Schrader J; Henneberg F; Mata RA; Tittmann K; Schneider TR; Stark H; Bourenkov G; Chari A
    Science; 2016 Aug; 353(6299):594-8. PubMed ID: 27493187
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Systematic comparison of peptidic proteasome inhibitors highlights the α-ketoamide electrophile as an auspicious reversible lead motif.
    Stein ML; Cui H; Beck P; Dubiella C; Voss C; Krüger A; Schmidt B; Groll M
    Angew Chem Int Ed Engl; 2014 Feb; 53(6):1679-83. PubMed ID: 24403024
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Long-range allosteric regulation of the human 26S proteasome by 20S proteasome-targeting cancer drugs.
    Haselbach D; Schrader J; Lambrecht F; Henneberg F; Chari A; Stark H
    Nat Commun; 2017 May; 8():15578. PubMed ID: 28541292
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Systematic Analyses of Substrate Preferences of 20S Proteasomes Using Peptidic Epoxyketone Inhibitors.
    Huber EM; de Bruin G; Heinemeyer W; Paniagua Soriano G; Overkleeft HS; Groll M
    J Am Chem Soc; 2015 Jun; 137(24):7835-42. PubMed ID: 26020686
    [TBL] [Abstract][Full Text] [Related]  

  • 6. α-Keto phenylamides as P1'-extended proteasome inhibitors.
    Voss C; Scholz C; Knorr S; Beck P; Stein ML; Zall A; Kuckelkorn U; Kloetzel PM; Groll M; Hamacher K; Schmidt B
    ChemMedChem; 2014 Nov; 9(11):2557-64. PubMed ID: 25087721
    [TBL] [Abstract][Full Text] [Related]  

  • 7. A mass spectrometry platform for a streamlined investigation of proteasome integrity, posttranslational modifications, and inhibitor binding.
    Gersch M; Hackl MW; Dubiella C; Dobrinevski A; Groll M; Sieber SA
    Chem Biol; 2015 Mar; 22(3):404-11. PubMed ID: 25728267
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Nonpeptidic Selective Inhibitors of the Chymotrypsin-Like (β5 i) Subunit of the Immunoproteasome.
    Sosič I; Gobec M; Brus B; Knez D; Živec M; Konc J; Lešnik S; Ogrizek M; Obreza A; Žigon D; Janežič D; Mlinarič-Raščan I; Gobec S
    Angew Chem Int Ed Engl; 2016 May; 55(19):5745-8. PubMed ID: 27037901
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Nature of pharmacophore influences active site specificity of proteasome inhibitors.
    Screen M; Britton M; Downey SL; Verdoes M; Voges MJ; Blom AE; Geurink PP; Risseeuw MD; Florea BI; van der Linden WA; Pletnev AA; Overkleeft HS; Kisselev AF
    J Biol Chem; 2010 Dec; 285(51):40125-34. PubMed ID: 20937826
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The cryo-EM structure of the Plasmodium falciparum 20S proteasome and its use in the fight against malaria.
    Li H; Bogyo M; da Fonseca PC
    FEBS J; 2016 Dec; 283(23):4238-4243. PubMed ID: 27286897
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits.
    Acosta-Alvear D; Cho MY; Wild T; Buchholz TJ; Lerner AG; Simakova O; Hahn J; Korde N; Landgren O; Maric I; Choudhary C; Walter P; Weissman JS; Kampmann M
    Elife; 2015 Sep; 4():e08153. PubMed ID: 26327694
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Progress curve analysis of the kinetics of slow-binding anticancer drug inhibitors of the 20S proteasome.
    Hasinoff BB
    Arch Biochem Biophys; 2018 Feb; 639():52-58. PubMed ID: 29305052
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Optimization of peptidomimetic boronates bearing a P3 bicyclic scaffold as proteasome inhibitors.
    Troiano V; Scarbaci K; Ettari R; Micale N; Cerchia C; Pinto A; Schirmeister T; Novellino E; Grasso S; Lavecchia A; Zappalà M
    Eur J Med Chem; 2014 Aug; 83():1-14. PubMed ID: 24946214
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Electrochemical assay for 20S proteasome activity and inhibition with anti-cancer drugs.
    Henriques de Jesus CS; Chiorcea-Paquim AM; Barsan MM; Diculescu VC
    Talanta; 2019 Jul; 199():32-39. PubMed ID: 30952265
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Computational Approaches for the Discovery of Human Proteasome Inhibitors: An Overview.
    Guedes RA; Serra P; Salvador JA; Guedes RC
    Molecules; 2016 Jul; 21(7):. PubMed ID: 27438821
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structural Elucidation of a Nonpeptidic Inhibitor Specific for the Human Immunoproteasome.
    Cui H; Baur R; Le Chapelain C; Dubiella C; Heinemeyer W; Huber EM; Groll M
    Chembiochem; 2017 Mar; 18(6):523-526. PubMed ID: 28098422
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Development of a new class of proteasome inhibitors with an epoxyketone warhead: Rational hybridization of non-peptidic belactosin derivatives and peptide epoxyketones.
    Kawamura S; Unno Y; Asai A; Arisawa M; Shuto S
    Bioorg Med Chem; 2014 Jun; 22(12):3091-5. PubMed ID: 24814885
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Blockade of the malignant phenotype by β-subunit selective noncovalent inhibition of immuno- and constitutive proteasomes.
    Villoutreix BO; Khatib AM; Cheng Y; Miteva MA; Maréchal X; Vidal J; Reboud-Ravaux M
    Oncotarget; 2017 Feb; 8(6):10437-10449. PubMed ID: 28060729
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Pipecolic esters as minimized templates for proteasome inhibition.
    Giletto MB; Osmulski PA; Jones CL; Gaczynska ME; Tepe JJ
    Org Biomol Chem; 2019 Mar; 17(10):2734-2746. PubMed ID: 30778435
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Interactions of the natural product kendomycin and the 20S proteasome.
    Beck P; Heinemeyer W; Späth AL; Elnakady Y; Müller R; Groll M
    J Mol Biol; 2014 Sep; 426(18):3108-3117. PubMed ID: 25038530
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.