626 related articles for article (PubMed ID: 27608597)
21. Presenilin Is Essential for ApoE Secretion, a Novel Role of Presenilin Involved in Alzheimer's Disease Pathogenesis.
Islam S; Sun Y; Gao Y; Nakamura T; Noorani AA; Li T; Wong PC; Kimura N; Matsubara E; Kasuga K; Ikeuchi T; Tomita T; Zou K; Michikawa M
J Neurosci; 2022 Feb; 42(8):1574-1586. PubMed ID: 34987110
[TBL] [Abstract][Full Text] [Related]
22. gamma-Secretase heterogeneity in the Aph1 subunit: relevance for Alzheimer's disease.
Serneels L; Van Biervliet J; Craessaerts K; Dejaegere T; Horré K; Van Houtvin T; Esselmann H; Paul S; Schäfer MK; Berezovska O; Hyman BT; Sprangers B; Sciot R; Moons L; Jucker M; Yang Z; May PC; Karran E; Wiltfang J; D'Hooge R; De Strooper B
Science; 2009 May; 324(5927):639-42. PubMed ID: 19299585
[TBL] [Abstract][Full Text] [Related]
23. Purification and characterization of the human gamma-secretase complex.
Fraering PC; Ye W; Strub JM; Dolios G; LaVoie MJ; Ostaszewski BL; van Dorsselaer A; Wang R; Selkoe DJ; Wolfe MS
Biochemistry; 2004 Aug; 43(30):9774-89. PubMed ID: 15274632
[TBL] [Abstract][Full Text] [Related]
24. γ-Secretase Modulators and APH1 Isoforms Modulate γ-Secretase Cleavage but Not Position of ε-Cleavage of the Amyloid Precursor Protein (APP).
Lessard CB; Cottrell BA; Maruyama H; Suresh S; Golde TE; Koo EH
PLoS One; 2015; 10(12):e0144758. PubMed ID: 26678856
[TBL] [Abstract][Full Text] [Related]
25. Flexible and Accurate Substrate Processing with Distinct Presenilin/γ-Secretases in Human Cortical Neurons.
Watanabe H; Imaizumi K; Cai T; Zhou Z; Tomita T; Okano H
eNeuro; 2021; 8(2):. PubMed ID: 33608391
[TBL] [Abstract][Full Text] [Related]
26. Toward the structure of presenilin/γ-secretase and presenilin homologs.
Wolfe MS
Biochim Biophys Acta; 2013 Dec; 1828(12):2886-97. PubMed ID: 24099007
[TBL] [Abstract][Full Text] [Related]
27. γ-Secretase complexes containing caspase-cleaved presenilin-1 increase intracellular Aβ(42) /Aβ(40) ratio.
Hedskog L; Petersen CA; Svensson AI; Welander H; Tjernberg LO; Karlström H; Ankarcrona M
J Cell Mol Med; 2011 Oct; 15(10):2150-63. PubMed ID: 21054783
[TBL] [Abstract][Full Text] [Related]
28. Are γ-secretase and its associated Alzheimer's disease γ problems?
Rodríguez-Manotas M; Amorín-Díaz M; Cabezas-Herrera J; Acedo-Martínez A; Llorca-Escuín I
Med Hypotheses; 2012 Feb; 78(2):299-304. PubMed ID: 22133557
[TBL] [Abstract][Full Text] [Related]
29. G206D Mutation of Presenilin-1 Reduces Pen2 Interaction, Increases Aβ42/Aβ40 Ratio and Elevates ER Ca(2+) Accumulation.
Chen WT; Hsieh YF; Huang YJ; Lin CC; Lin YT; Liu YC; Lien CC; Cheng IH
Mol Neurobiol; 2015 Dec; 52(3):1835-1849. PubMed ID: 25394380
[TBL] [Abstract][Full Text] [Related]
30. Genes and mechanisms involved in beta-amyloid generation and Alzheimer's disease.
Steiner H; Capell A; Leimer U; Haass C
Eur Arch Psychiatry Clin Neurosci; 1999; 249(6):266-70. PubMed ID: 10653281
[TBL] [Abstract][Full Text] [Related]
31. Analysis of 138 pathogenic mutations in presenilin-1 on the in vitro production of Aβ42 and Aβ40 peptides by γ-secretase.
Sun L; Zhou R; Yang G; Shi Y
Proc Natl Acad Sci U S A; 2017 Jan; 114(4):E476-E485. PubMed ID: 27930341
[TBL] [Abstract][Full Text] [Related]
32. Mutant presenilins specifically elevate the levels of the 42 residue beta-amyloid peptide in vivo: evidence for augmentation of a 42-specific gamma secretase.
Jankowsky JL; Fadale DJ; Anderson J; Xu GM; Gonzales V; Jenkins NA; Copeland NG; Lee MK; Younkin LH; Wagner SL; Younkin SG; Borchelt DR
Hum Mol Genet; 2004 Jan; 13(2):159-70. PubMed ID: 14645205
[TBL] [Abstract][Full Text] [Related]
33. Effects of Folic Acid on Secretases Involved in Aβ Deposition in APP/PS1 Mice.
Tian T; Bai D; Li W; Huang GW; Liu H
Nutrients; 2016 Sep; 8(9):. PubMed ID: 27618097
[TBL] [Abstract][Full Text] [Related]
34. Alzheimer's disease-linked mutations in presenilin-1 result in a drastic loss of activity in purified γ-secretase complexes.
Cacquevel M; Aeschbach L; Houacine J; Fraering PC
PLoS One; 2012; 7(4):e35133. PubMed ID: 22529981
[TBL] [Abstract][Full Text] [Related]
35. The large hydrophilic loop of presenilin 1 is important for regulating gamma-secretase complex assembly and dictating the amyloid beta peptide (Abeta) Profile without affecting Notch processing.
Wanngren J; Frånberg J; Svensson AI; Laudon H; Olsson F; Winblad B; Liu F; Näslund J; Lundkvist J; Karlström H
J Biol Chem; 2010 Mar; 285(12):8527-36. PubMed ID: 20106965
[TBL] [Abstract][Full Text] [Related]
36. Induction of Amyloid-β42 Production by Fipronil and Other Pyrazole Insecticides.
Cam M; Durieu E; Bodin M; Manousopoulou A; Koslowski S; Vasylieva N; Barnych B; Hammock BD; Bohl B; Koch P; Omori C; Yamamoto K; Hata S; Suzuki T; Karg F; Gizzi P; Erakovic Haber V; Bencetic Mihaljevic V; Tavcar B; Portelius E; Pannee J; Blennow K; Zetterberg H; Garbis SD; Auvray P; Gerber H; Fraering J; Fraering PC; Meijer L
J Alzheimers Dis; 2018; 62(4):1663-1681. PubMed ID: 29504531
[TBL] [Abstract][Full Text] [Related]
37. In vitro reconstitution of gamma-secretase activity using yeast microsomes.
Yagishita S; Futai E; Ishiura S
Biochem Biophys Res Commun; 2008 Dec; 377(1):141-5. PubMed ID: 18834861
[TBL] [Abstract][Full Text] [Related]
38. Bax inhibitor 1 is a γ-secretase-independent presenilin-binding protein.
Wu S; Song W; Wong CCL; Shi Y
Proc Natl Acad Sci U S A; 2019 Jan; 116(1):141-147. PubMed ID: 30559186
[TBL] [Abstract][Full Text] [Related]
39. Immature nicastrin stabilizes APH-1 independent of PEN-2 and presenilin: identification of nicastrin mutants that selectively interact with APH-1.
Shirotani K; Edbauer D; Kostka M; Steiner H; Haass C
J Neurochem; 2004 Jun; 89(6):1520-7. PubMed ID: 15189355
[TBL] [Abstract][Full Text] [Related]
40. Specific Mutations in Aph1 Cause γ-Secretase Activation.
Watanabe H; Yoshida C; Hidaka M; Ogawa T; Tomita T; Futai E
Int J Mol Sci; 2022 Jan; 23(1):. PubMed ID: 35008932
[TBL] [Abstract][Full Text] [Related]
[Previous] [Next] [New Search]