BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

190 related articles for article (PubMed ID: 27617850)

  • 1. Selective Covalent Targeting of Anti-Apoptotic BFL-1 by Cysteine-Reactive Stapled Peptide Inhibitors.
    Huhn AJ; Guerra RM; Harvey EP; Bird GH; Walensky LD
    Cell Chem Biol; 2016 Sep; 23(9):1123-1134. PubMed ID: 27617850
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Crystal Structures of Anti-apoptotic BFL-1 and Its Complex with a Covalent Stapled Peptide Inhibitor.
    Harvey EP; Seo HS; Guerra RM; Bird GH; Dhe-Paganon S; Walensky LD
    Structure; 2018 Jan; 26(1):153-160.e4. PubMed ID: 29276033
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Identification of a Covalent Molecular Inhibitor of Anti-apoptotic BFL-1 by Disulfide Tethering.
    Harvey EP; Hauseman ZJ; Cohen DT; Rettenmaier TJ; Lee S; Huhn AJ; Wales TE; Seo HS; Luccarelli J; Newman CE; Guerra RM; Bird GH; Dhe-Paganon S; Engen JR; Wells JA; Walensky LD
    Cell Chem Biol; 2020 Jun; 27(6):647-656.e6. PubMed ID: 32413285
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Selective Covalent Targeting of Anti-apoptotic BFL-1 by a Sulfonium-Tethered Peptide.
    Liu N; Wang D; Lian C; Zhao R; Tu L; Zhang Y; Liu J; Zhu H; Yu M; Wan C; Li D; Li S; Yin F; Li Z
    Chembiochem; 2021 Jan; 22(2):340-344. PubMed ID: 32790056
    [TBL] [Abstract][Full Text] [Related]  

  • 5. A redox switch regulates the structure and function of anti-apoptotic BFL-1.
    Korshavn KJ; Wales TE; Bird GH; Engen JR; Walensky LD
    Nat Struct Mol Biol; 2020 Sep; 27(9):781-789. PubMed ID: 32661419
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Relationship between helix stability and binding affinities: molecular dynamics simulations of Bfl-1/A1-binding pro-apoptotic BH3 peptide helices in explicit solvent.
    Modi V; Lama D; Sankararamakrishnan R
    J Biomol Struct Dyn; 2013; 31(1):65-77. PubMed ID: 22803956
    [TBL] [Abstract][Full Text] [Related]  

  • 7. hBfl-1/hNOXA Interaction Studies Provide New Insights on the Role of Bfl-1 in Cancer Cell Resistance and for the Design of Novel Anticancer Agents.
    Barile E; Marconi GD; De SK; Baggio C; Gambini L; Salem AF; Kashyap MK; Castro JE; Kipps TJ; Pellecchia M
    ACS Chem Biol; 2017 Feb; 12(2):444-455. PubMed ID: 28026162
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Precision Targeting of BFL-1/A1 and an ATM Co-dependency in Human Cancer.
    Guerra RM; Bird GH; Harvey EP; Dharia NV; Korshavn KJ; Prew MS; Stegmaier K; Walensky LD
    Cell Rep; 2018 Sep; 24(13):3393-3403.e5. PubMed ID: 30257201
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Identification of Small Inhibitory Molecules Targeting the Bfl-1 Anti-Apoptotic Protein That Alleviates Resistance to ABT-737.
    Mathieu AL; Sperandio O; Pottiez V; Balzarin S; Herlédan A; Elkaïm JO; Fogeron ML; Piveteau C; Dassonneville S; Deprez B; Villoutreix BO; Bonnefoy N; Leroux F
    J Biomol Screen; 2014 Aug; 19(7):1035-46. PubMed ID: 24809353
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Peptide ligands for pro-survival protein Bfl-1 from computationally guided library screening.
    Dutta S; Chen TS; Keating AE
    ACS Chem Biol; 2013 Apr; 8(4):778-88. PubMed ID: 23363053
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Epistatic mutations in PUMA BH3 drive an alternate binding mode to potently and selectively inhibit anti-apoptotic Bfl-1.
    Jenson JM; Ryan JA; Grant RA; Letai A; Keating AE
    Elife; 2017 Jun; 6():. PubMed ID: 28594323
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Discovery of a selective and covalent small-molecule inhibitor of BFL-1 protein that induces robust apoptosis in cancer cells.
    Feng X; Yan Z; Zhou F; Lou J; Lyu X; Ren X; Zeng Z; Liu C; Zhang S; Zhu D; Huang H; Yang J; Zhao Y
    Eur J Med Chem; 2022 Jun; 236():114327. PubMed ID: 35385805
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Binding modes of Bcl-2 homology 3 (BH3) peptides with anti-apoptotic protein A1 and redesign of peptide inhibitors: a computational study.
    Chen Y; Wang J; Zhang J; Wang W
    J Biomol Struct Dyn; 2018 Nov; 36(15):3967-3977. PubMed ID: 29137527
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Inhibitors of BCL2A1/Bfl-1 protein: Potential stock in cancer therapy.
    Li X; Dou J; You Q; Jiang Z
    Eur J Med Chem; 2021 Aug; 220():113539. PubMed ID: 34034128
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Characterization of peptide aptamers targeting Bfl-1 anti-apoptotic protein.
    Brien G; Debaud AL; Bickle M; Trescol-Biemont MC; Moncorge O; Colas P; Bonnefoy-Berard N
    Biochemistry; 2011 Jun; 50(23):5120-9. PubMed ID: 21563784
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Potent and specific peptide inhibitors of human pro-survival protein Bcl-xL.
    Dutta S; Ryan J; Chen TS; Kougentakis C; Letai A; Keating AE
    J Mol Biol; 2015 Mar; 427(6 Pt B):1241-1253. PubMed ID: 25451027
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Binding affinity of pro-apoptotic BH3 peptides for the anti-apoptotic Mcl-1 and A1 proteins: Molecular dynamics simulations of Mcl-1 and A1 in complex with six different BH3 peptides.
    Modi V; Sankararamakrishnan R
    J Mol Graph Model; 2017 May; 73():115-128. PubMed ID: 28279820
    [TBL] [Abstract][Full Text] [Related]  

  • 18. High-throughput fluorescence polarization assay for chemical library screening against anti-apoptotic Bcl-2 family member Bfl-1.
    Zhai D; Godoi P; Sergienko E; Dahl R; Chan X; Brown B; Rascon J; Hurder A; Su Y; Chung TD; Jin C; Diaz P; Reed JC
    J Biomol Screen; 2012 Mar; 17(3):350-60. PubMed ID: 22156224
    [TBL] [Abstract][Full Text] [Related]  

  • 19. BH3 mimetic ABT-737 and a proteasome inhibitor synergistically kill melanomas through Noxa-dependent apoptosis.
    Miller LA; Goldstein NB; Johannes WU; Walton CH; Fujita M; Norris DA; Shellman YG
    J Invest Dermatol; 2009 Apr; 129(4):964-71. PubMed ID: 18987671
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Functional dissection of Bfl-1, a Bcl-2 homolog: anti-apoptosis, oncogene-cooperation and cell proliferation activities.
    D'Sa-Eipper C; Chinnadurai G
    Oncogene; 1998 Jun; 16(24):3105-14. PubMed ID: 9671389
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.