BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

148 related articles for article (PubMed ID: 27617984)

  • 1. Boronic Acid Group: A Cumbersome False Negative Case in the Process of Drug Design.
    Katsamakas S; Papadopoulos AG; Hadjipavlou-Litina D
    Molecules; 2016 Sep; 21(9):. PubMed ID: 27617984
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure-based design of novel boronic acid-based inhibitors of autotaxin.
    Albers HM; Hendrickx LJ; van Tol RJ; Hausmann J; Perrakis A; Ovaa H
    J Med Chem; 2011 Jul; 54(13):4619-26. PubMed ID: 21615078
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Development of Autotaxin Inhibitors: An Overview of the Patent and Primary Literature.
    Castagna D; Budd DC; Macdonald SJ; Jamieson C; Watson AJ
    J Med Chem; 2016 Jun; 59(12):5604-21. PubMed ID: 26745766
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Screening and X-ray crystal structure-based optimization of autotaxin (ENPP2) inhibitors, using a newly developed fluorescence probe.
    Kawaguchi M; Okabe T; Okudaira S; Nishimasu H; Ishitani R; Kojima H; Nureki O; Aoki J; Nagano T
    ACS Chem Biol; 2013 Aug; 8(8):1713-21. PubMed ID: 23688339
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Repurposing Suzuki Coupling Reagents as a Directed Fragment Library Targeting Serine Hydrolases and Related Enzymes.
    Lanier M; Cole DC; Istratiy Y; Klein MG; Schwartz PA; Tjhen R; Jennings A; Hixon MS
    J Med Chem; 2017 Jun; 60(12):5209-5215. PubMed ID: 28564542
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Design, synthesis, and biological evaluation of 2,4-dihydropyrano[2,3-c]pyrazole derivatives as autotaxin inhibitors.
    Pantsar T; Singha P; Nevalainen TJ; Koshevoy I; Leppänen J; Poso A; Niskanen JMA; Pasonen-Seppänen S; Savinainen JR; Laitinen T; Laitinen JT
    Eur J Pharm Sci; 2017 Sep; 107():97-111. PubMed ID: 28687529
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure-Activity Relationships of Small Molecule Autotaxin Inhibitors with a Discrete Binding Mode.
    Miller LM; Keune WJ; Castagna D; Young LC; Duffy EL; Potjewyd F; Salgado-Polo F; Engel García P; Semaan D; Pritchard JM; Perrakis A; Macdonald SJ; Jamieson C; Watson AJ
    J Med Chem; 2017 Jan; 60(2):722-748. PubMed ID: 27982588
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Discovery and synthetic optimization of a novel scaffold for hydrophobic tunnel-targeted autotaxin inhibition.
    Ragle LE; Palanisamy DJ; Joe MJ; Stein RS; Norman DD; Tigyi G; Baker DL; Parrill AL
    Bioorg Med Chem; 2016 Oct; 24(19):4660-4674. PubMed ID: 27544588
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Discovery and optimization of boronic acid based inhibitors of autotaxin.
    Albers HM; van Meeteren LA; Egan DA; van Tilburg EW; Moolenaar WH; Ovaa H
    J Med Chem; 2010 Jul; 53(13):4958-67. PubMed ID: 20536182
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Pharmacophoric Site Identification and Inhibitor Design for Autotaxin.
    Lee MH; Lee DY; Balupuri A; Jeong JW; Kang NS
    Molecules; 2019 Aug; 24(15):. PubMed ID: 31374894
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Design, synthesis, docking and biological evaluation of 4-phenyl-thiazole derivatives as autotaxin (ATX) inhibitors.
    Balupuri A; Lee DY; Lee MH; Chae S; Jung E; Kim Y; Ryu J; Kang NS
    Bioorg Med Chem Lett; 2017 Sep; 27(17):4156-4164. PubMed ID: 28743508
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Structural Basis for Inhibition of Human Autotaxin by Four Potent Compounds with Distinct Modes of Binding.
    Stein AJ; Bain G; Prodanovich P; Santini AM; Darlington J; Stelzer NM; Sidhu RS; Schaub J; Goulet L; Lonergan D; Calderon I; Evans JF; Hutchinson JH
    Mol Pharmacol; 2015 Dec; 88(6):982-92. PubMed ID: 26371182
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structure-based discovery of (S)-2-amino-6-(4-fluorobenzyl)-5,6,11,11a-tetrahydro-1H-imidazo[1',5':1,6]pyrido[3,4-b]indole-1,3(2H)-dione as low nanomolar, orally bioavailable autotaxin inhibitor.
    Roy A; Sarkar T; Datta S; Maiti A; Chakrabarti M; Mondal T; Mondal C; Banerjee A; Roy S; Mukherjee S; Muley P; Chakraborty S; Banerjee M; Kundu M; Roy KK
    Chem Biol Drug Des; 2022 Mar; 99(3):496-503. PubMed ID: 34951520
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Crystal structure of Escherichia coli penicillin-binding protein 5 bound to a tripeptide boronic acid inhibitor: a role for Ser-110 in deacylation.
    Nicola G; Peddi S; Stefanova M; Nicholas RA; Gutheil WG; Davies C
    Biochemistry; 2005 Jun; 44(23):8207-17. PubMed ID: 15938610
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Computer Aided Drug Design Approaches for Identification of Novel Autotaxin (ATX) Inhibitors.
    Vrontaki E; Melagraki G; Kaffe E; Mavromoustakos T; Kokotos G; Aidinis V; Afantitis A
    Curr Med Chem; 2016; 23(17):1708-24. PubMed ID: 26997151
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Unexpected tricovalent binding mode of boronic acids within the active site of a penicillin-binding protein.
    Zervosen A; Herman R; Kerff F; Herman A; Bouillez A; Prati F; Pratt RF; Frère JM; Joris B; Luxen A; Charlier P; Sauvage E
    J Am Chem Soc; 2011 Jul; 133(28):10839-48. PubMed ID: 21574608
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Discovery and optimization of ATX inhibitors via modeling, synthesis and biological evaluation.
    Balupuri A; Lee MH; Chae S; Jung E; Yoon W; Kim Y; Son SJ; Ryu J; Kang DH; Yang YJ; You JN; Kwon H; Jeong JW; Koo TS; Lee DY; Kang NS
    Eur J Med Chem; 2018 Mar; 148():397-409. PubMed ID: 29477073
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Autotaxin inhibition: development and application of computational tools to identify site-selective lead compounds.
    Norman DD; Ibezim A; Scott WE; White S; Parrill AL; Baker DL
    Bioorg Med Chem; 2013 Sep; 21(17):5548-60. PubMed ID: 23816044
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Discovery of non-boronic acid Arginase 1 inhibitors through virtual screening and biophysical methods.
    Gathiaka S; Palte RL; So SS; Chai X; Richard Miller J; Kuvelkar R; Wen X; Cifelli S; Kreamer A; Liaw A; McLaren DG; Fischer C
    Bioorg Med Chem Lett; 2023 Mar; 84():129193. PubMed ID: 36822300
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Differences in binding modes of enantiomers of 1-acetamido boronic acid based protease inhibitors: crystal structures of gamma-chymotrypsin and subtilisin Carlsberg complexes.
    Stoll VS; Eger BT; Hynes RC; Martichonok V; Jones JB; Pai EF
    Biochemistry; 1998 Jan; 37(2):451-62. PubMed ID: 9425066
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.