These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

190 related articles for article (PubMed ID: 27621483)

  • 1. 'Up with the LRRK': a phosphorylated Rab10 assay for evaluation of LRRK2 activity and inhibitor engagement.
    Eyers PA
    Biochem J; 2016 Sep; 473(18):2757-62. PubMed ID: 27621483
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Phos-tag analysis of Rab10 phosphorylation by LRRK2: a powerful assay for assessing kinase function and inhibitors.
    Ito G; Katsemonova K; Tonelli F; Lis P; Baptista MA; Shpiro N; Duddy G; Wilson S; Ho PW; Ho SL; Reith AD; Alessi DR
    Biochem J; 2016 Sep; 473(17):2671-85. PubMed ID: 27474410
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Selective LRRK2 kinase inhibition reduces phosphorylation of endogenous Rab10 and Rab12 in human peripheral mononuclear blood cells.
    Thirstrup K; Dächsel JC; Oppermann FS; Williamson DS; Smith GP; Fog K; Christensen KV
    Sci Rep; 2017 Aug; 7(1):10300. PubMed ID: 28860483
    [TBL] [Abstract][Full Text] [Related]  

  • 4. LRRK2-mediated Rab10 phosphorylation in immune cells from Parkinson's disease patients.
    Atashrazm F; Hammond D; Perera G; Bolliger MF; Matar E; Halliday GM; Schüle B; Lewis SJG; Nichols RJ; Dzamko N
    Mov Disord; 2019 Mar; 34(3):406-415. PubMed ID: 30597610
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Deciphering the LRRK code: LRRK1 and LRRK2 phosphorylate distinct Rab proteins and are regulated by diverse mechanisms.
    Malik AU; Karapetsas A; Nirujogi RS; Mathea S; Chatterjee D; Pal P; Lis P; Taylor M; Purlyte E; Gourlay R; Dorward M; Weidlich S; Toth R; Polinski NK; Knapp S; Tonelli F; Alessi DR
    Biochem J; 2021 Feb; 478(3):553-578. PubMed ID: 33459343
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Development of phospho-specific Rab protein antibodies to monitor
    Lis P; Burel S; Steger M; Mann M; Brown F; Diez F; Tonelli F; Holton JL; Ho PW; Ho SL; Chou MY; Polinski NK; Martinez TN; Davies P; Alessi DR
    Biochem J; 2018 Jan; 475(1):1-22. PubMed ID: 29127256
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Interrogating Parkinson's disease LRRK2 kinase pathway activity by assessing Rab10 phosphorylation in human neutrophils.
    Fan Y; Howden AJM; Sarhan AR; Lis P; Ito G; Martinez TN; Brockmann K; Gasser T; Alessi DR; Sammler EM
    Biochem J; 2018 Jan; 475(1):23-44. PubMed ID: 29127255
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Accurate MS-based Rab10 Phosphorylation Stoichiometry Determination as Readout for LRRK2 Activity in Parkinson's Disease.
    Karayel Ö; Tonelli F; Virreira Winter S; Geyer PE; Fan Y; Sammler EM; Alessi DR; Steger M; Mann M
    Mol Cell Proteomics; 2020 Sep; 19(9):1546-1560. PubMed ID: 32601174
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Genetic background influences LRRK2-mediated Rab phosphorylation in the rat brain.
    Kelly K; Chang A; Hastings L; Abdelmotilib H; West AB
    Brain Res; 2021 May; 1759():147372. PubMed ID: 33600829
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human.
    Mir R; Tonelli F; Lis P; Macartney T; Polinski NK; Martinez TN; Chou MY; Howden AJM; König T; Hotzy C; Milenkovic I; Brücke T; Zimprich A; Sammler E; Alessi DR
    Biochem J; 2018 Jun; 475(11):1861-1883. PubMed ID: 29743203
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Single molecule array measures of LRRK2 kinase activity in serum link Parkinson's disease severity to peripheral inflammation.
    Yuan Y; Li H; Sreeram K; Malankhanova T; Boddu R; Strader S; Chang A; Bryant N; Yacoubian TA; Standaert DG; Erb M; Moore DJ; Sanders LH; Lutz MW; Velmeshev D; West AB
    Mol Neurodegener; 2024 Jun; 19(1):47. PubMed ID: 38862989
    [TBL] [Abstract][Full Text] [Related]  

  • 12. A feed-forward pathway drives LRRK2 kinase membrane recruitment and activation.
    Vides EG; Adhikari A; Chiang CY; Lis P; Purlyte E; Limouse C; Shumate JL; Spínola-Lasso E; Dhekne HS; Alessi DR; Pfeffer SR
    Elife; 2022 Sep; 11():. PubMed ID: 36149401
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Development of a multiplexed targeted mass spectrometry assay for LRRK2-phosphorylated Rabs and Ser910/Ser935 biomarker sites.
    Nirujogi RS; Tonelli F; Taylor M; Lis P; Zimprich A; Sammler E; Alessi DR
    Biochem J; 2021 Jan; 478(2):299-326. PubMed ID: 33367571
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Roles of lysosomotropic agents on LRRK2 activation and Rab10 phosphorylation.
    Kuwahara T; Funakawa K; Komori T; Sakurai M; Yoshii G; Eguchi T; Fukuda M; Iwatsubo T
    Neurobiol Dis; 2020 Nov; 145():105081. PubMed ID: 32919031
    [TBL] [Abstract][Full Text] [Related]  

  • 15.
    Wauters F; Cornelissen T; Imberechts D; Martin S; Koentjoro B; Sue C; Vangheluwe P; Vandenberghe W
    Autophagy; 2020 Feb; 16(2):203-222. PubMed ID: 30945962
    [TBL] [Abstract][Full Text] [Related]  

  • 16. R1441G but not G2019S mutation enhances LRRK2 mediated Rab10 phosphorylation in human peripheral blood neutrophils.
    Fan Y; Nirujogi RS; Garrido A; Ruiz-Martínez J; Bergareche-Yarza A; Mondragón-Rezola E; Vinagre-Aragón A; Croitoru I; Gorostidi Pagola A; Paternain Markinez L; Alcalay R; Hickman RA; Düring J; Gomes S; Pratuseviciute N; Padmanabhan S; Valldeoriola F; Pérez Sisqués L; Malagelada C; Ximelis T; Molina Porcel L; Martí MJ; Tolosa E; Alessi DR; Sammler EM
    Acta Neuropathol; 2021 Sep; 142(3):475-494. PubMed ID: 34125248
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Cellular and subcellular localization of Rab10 and phospho-T73 Rab10 in the mouse and human brain.
    Singh V; Menard MA; Serrano GE; Beach TG; Zhao HT; Riley-DiPaolo A; Subrahmanian N; LaVoie MJ; Volpicelli-Daley LA
    Acta Neuropathol Commun; 2023 Dec; 11(1):201. PubMed ID: 38110990
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes.
    Wang X; Bondar VV; Davis OB; Maloney MT; Agam M; Chin MY; Cheuk-Nga Ho A; Ghosh R; Leto DE; Joy D; Calvert MEK; Lewcock JW; Di Paolo G; Thorne RG; Sweeney ZK; Henry AG
    Elife; 2023 Oct; 12():. PubMed ID: 37874617
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Rab10 Phosphorylation Detection by LRRK2 Activity Using SDS-PAGE with a Phosphate-binding Tag.
    Ito G; Tomita T
    J Vis Exp; 2017 Dec; (130):. PubMed ID: 29286425
    [TBL] [Abstract][Full Text] [Related]  

  • 20. RAB8, RAB10 and RILPL1 contribute to both LRRK2 kinase-mediated centrosomal cohesion and ciliogenesis deficits.
    Lara Ordónez AJ; Fernández B; Fdez E; Romo-Lozano M; Madero-Pérez J; Lobbestael E; Baekelandt V; Aiastui A; López de Munaín A; Melrose HL; Civiero L; Hilfiker S
    Hum Mol Genet; 2019 Nov; 28(21):3552-3568. PubMed ID: 31428781
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.