BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

205 related articles for article (PubMed ID: 27624966)

  • 1. Crystal Structures of Trimethoprim-Resistant DfrA1 Rationalize Potent Inhibition by Propargyl-Linked Antifolates.
    Lombardo MN; G-Dayanandan N; Wright DL; Anderson AC
    ACS Infect Dis; 2016 Feb; 2(2):149-56. PubMed ID: 27624966
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Crystal structures of Klebsiella pneumoniae dihydrofolate reductase bound to propargyl-linked antifolates reveal features for potency and selectivity.
    Lamb KM; Lombardo MN; Alverson J; Priestley ND; Wright DL; Anderson AC
    Antimicrob Agents Chemother; 2014 Dec; 58(12):7484-91. PubMed ID: 25288083
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Structure-guided functional studies of plasmid-encoded dihydrofolate reductases reveal a common mechanism of trimethoprim resistance in Gram-negative pathogens.
    Krucinska J; Lombardo MN; Erlandsen H; Estrada A; Si D; Viswanathan K; Wright DL
    Commun Biol; 2022 May; 5(1):459. PubMed ID: 35562546
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Charged Propargyl-Linked Antifolates Reveal Mechanisms of Antifolate Resistance and Inhibit Trimethoprim-Resistant MRSA Strains Possessing Clinically Relevant Mutations.
    Reeve SM; Scocchera E; Ferreira JJ; G-Dayanandan N; Keshipeddy S; Wright DL; Anderson AC
    J Med Chem; 2016 Jul; 59(13):6493-500. PubMed ID: 27308944
    [TBL] [Abstract][Full Text] [Related]  

  • 5. In vitro efficacy of new antifolates against trimethoprim-resistant Bacillus anthracis.
    Barrow EW; Dreier J; Reinelt S; Bourne PC; Barrow WW
    Antimicrob Agents Chemother; 2007 Dec; 51(12):4447-52. PubMed ID: 17875993
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Toward Broad Spectrum Dihydrofolate Reductase Inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin Resistant
    Reeve SM; Si D; Krucinska J; Yan Y; Viswanathan K; Wang S; Holt GT; Frenkel MS; Ojewole AA; Estrada A; Agabiti SS; Alverson JB; Gibson ND; Priestley ND; Wiemer AJ; Donald BR; Wright DL
    ACS Infect Dis; 2019 Nov; 5(11):1896-1906. PubMed ID: 31565920
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Towards the understanding of resistance mechanisms in clinically isolated trimethoprim-resistant, methicillin-resistant Staphylococcus aureus dihydrofolate reductase.
    Frey KM; Lombardo MN; Wright DL; Anderson AC
    J Struct Biol; 2010 Apr; 170(1):93-7. PubMed ID: 20026215
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Crystal structures of wild-type and mutant methicillin-resistant Staphylococcus aureus dihydrofolate reductase reveal an alternate conformation of NADPH that may be linked to trimethoprim resistance.
    Frey KM; Liu J; Lombardo MN; Bolstad DB; Wright DL; Anderson AC
    J Mol Biol; 2009 Apr; 387(5):1298-308. PubMed ID: 19249312
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Increased substrate affinity in the Escherichia coli L28R dihydrofolate reductase mutant causes trimethoprim resistance.
    Abdizadeh H; Tamer YT; Acar O; Toprak E; Atilgan AR; Atilgan C
    Phys Chem Chem Phys; 2017 May; 19(18):11416-11428. PubMed ID: 28422217
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Fragment-based design of symmetrical bis-benzimidazoles as selective inhibitors of the trimethoprim-resistant, type II R67 dihydrofolate reductase.
    Bastien D; Ebert MC; Forge D; Toulouse J; Kadnikova N; Perron F; Mayence A; Huang TL; Vanden Eynde JJ; Pelletier JN
    J Med Chem; 2012 Apr; 55(7):3182-92. PubMed ID: 22424148
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Nonracemic Antifolates Stereoselectively Recruit Alternate Cofactors and Overcome Resistance in S. aureus.
    Keshipeddy S; Reeve SM; Anderson AC; Wright DL
    J Am Chem Soc; 2015 Jul; 137(28):8983-90. PubMed ID: 26098608
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Molecular characterisation of trimethoprim resistance in Escherichia coli and Klebsiella pneumoniae during a two year intervention on trimethoprim use.
    Brolund A; Sundqvist M; Kahlmeter G; Grape M
    PLoS One; 2010 Feb; 5(2):e9233. PubMed ID: 20169085
    [TBL] [Abstract][Full Text] [Related]  

  • 13. A trimethoprim derivative impedes antibiotic resistance evolution.
    Manna MS; Tamer YT; Gaszek I; Poulides N; Ahmed A; Wang X; Toprak FCR; Woodard DR; Koh AY; Williams NS; Borek D; Atilgan AR; Hulleman JD; Atilgan C; Tambar U; Toprak E
    Nat Commun; 2021 May; 12(1):2949. PubMed ID: 34011959
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Chiral evasion and stereospecific antifolate resistance in Staphylococcus aureus.
    Wang S; Reeve SM; Holt GT; Ojewole AA; Frenkel MS; Gainza P; Keshipeddy S; Fowler VG; Wright DL; Donald BR
    PLoS Comput Biol; 2022 Feb; 18(2):e1009855. PubMed ID: 35143481
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Prospective screening of novel antibacterial inhibitors of dihydrofolate reductase for mutational resistance.
    Frey KM; Viswanathan K; Wright DL; Anderson AC
    Antimicrob Agents Chemother; 2012 Jul; 56(7):3556-62. PubMed ID: 22491688
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Interaction of dihydrofolate reductase and aminoglycoside adenyltransferase enzyme from Klebsiella pneumoniae multidrug resistant strain DF12SA with clindamycin: a molecular modelling and docking study.
    Shahi SK; Singh VK; Kumar A; Gupta SK; Singh SK
    J Mol Model; 2013 Mar; 19(3):973-83. PubMed ID: 23097003
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Antifolate activity of epigallocatechin gallate against Stenotrophomonas maltophilia.
    Navarro-Martínez MD; Navarro-Perán E; Cabezas-Herrera J; Ruiz-Gómez J; García-Cánovas F; Rodríguez-López JN
    Antimicrob Agents Chemother; 2005 Jul; 49(7):2914-20. PubMed ID: 15980368
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Towards new antifolates targeting eukaryotic opportunistic infections.
    Liu J; Bolstad DB; Bolstad ES; Wright DL; Anderson AC
    Eukaryot Cell; 2009 Apr; 8(4):483-6. PubMed ID: 19168759
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The prevalence of trimethoprim-resistance-conferring dihydrofolate reductase genes in urinary isolates of Escherichia coli in Korea.
    Lee JC; Oh JY; Cho JW; Park JC; Kim JM; Seol SY; Cho DT
    J Antimicrob Chemother; 2001 May; 47(5):599-604. PubMed ID: 11328770
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Characteristics of extended-spectrum cephalosporin-resistant Escherichia coli and Klebsiella pneumoniae isolates from horses.
    Vo AT; van Duijkeren E; Fluit AC; Gaastra W
    Vet Microbiol; 2007 Oct; 124(3-4):248-55. PubMed ID: 17521833
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.