193 related articles for article (PubMed ID: 27636112)
1. Overview of Critical Parameters for the Design and Execution of a High-Throughput Screen for Allosteric Ligands.
Alt A
Curr Protoc Pharmacol; 2016 Sep; 74():9.20.1-9.20.23. PubMed ID: 27636112
[TBL] [Abstract][Full Text] [Related]
2. Mapping Cannabinoid 1 Receptor Allosteric Site(s): Critical Molecular Determinant and Signaling Profile of GAT100, a Novel, Potent, and Irreversibly Binding Probe.
Laprairie RB; Kulkarni AR; Kulkarni PM; Hurst DP; Lynch D; Reggio PH; Janero DR; Pertwee RG; Stevenson LA; Kelly ME; Denovan-Wright EM; Thakur GA
ACS Chem Neurosci; 2016 Jun; 7(6):776-98. PubMed ID: 27046127
[TBL] [Abstract][Full Text] [Related]
3. Computational Advances for the Development of Allosteric Modulators and Bitopic Ligands in G Protein-Coupled Receptors.
Feng Z; Hu G; Ma S; Xie XQ
AAPS J; 2015 Sep; 17(5):1080-95. PubMed ID: 25940084
[TBL] [Abstract][Full Text] [Related]
4. Impact of allosteric modulation: Exploring the binding kinetics of glutamate and other orthosteric ligands of the metabotropic glutamate receptor 2.
Doornbos MLJ; Vermond SC; Lavreysen H; Tresadern G; IJzerman AP; Heitman LH
Biochem Pharmacol; 2018 Sep; 155():356-365. PubMed ID: 30028996
[TBL] [Abstract][Full Text] [Related]
5. Characterization of the novel positive allosteric modulator, LY2119620, at the muscarinic M(2) and M(4) receptors.
Croy CH; Schober DA; Xiao H; Quets A; Christopoulos A; Felder CC
Mol Pharmacol; 2014 Jul; 86(1):106-15. PubMed ID: 24807965
[TBL] [Abstract][Full Text] [Related]
6. How Do Modulators Affect the Orthosteric and Allosteric Binding Pockets?
Chen CJ; Jiang C; Yuan J; Chen M; Cuyler J; Xie XQ; Feng Z
ACS Chem Neurosci; 2022 Apr; 13(7):959-977. PubMed ID: 35298129
[TBL] [Abstract][Full Text] [Related]
7. Development of a high-throughput calcium flux assay for identification of all ligand types including positive, negative, and silent allosteric modulators for G protein-coupled receptors.
Noblin DJ; Bertekap RL; Burford NT; Hendricson A; Zhang L; Knox R; Banks M; O'Connell J; Alt A
Assay Drug Dev Technol; 2012 Oct; 10(5):457-67. PubMed ID: 22746835
[TBL] [Abstract][Full Text] [Related]
8. PAM-Antagonists: A Better Way to Block Pathological Receptor Signaling?
Kenakin T; Strachan RT
Trends Pharmacol Sci; 2018 Aug; 39(8):748-765. PubMed ID: 29885909
[TBL] [Abstract][Full Text] [Related]
9. Allosteric modulators of G-protein-coupled receptors.
May LT; Christopoulos A
Curr Opin Pharmacol; 2003 Oct; 3(5):551-6. PubMed ID: 14559102
[TBL] [Abstract][Full Text] [Related]
10. Strategies for the identification of allosteric modulators of G-protein-coupled receptors.
Burford NT; Watson J; Bertekap R; Alt A
Biochem Pharmacol; 2011 Mar; 81(6):691-702. PubMed ID: 21184747
[TBL] [Abstract][Full Text] [Related]
11. Biased allosteric agonism and modulation of metabotropic glutamate receptor 5: Implications for optimizing preclinical neuroscience drug discovery.
Sengmany K; Singh J; Stewart GD; Conn PJ; Christopoulos A; Gregory KJ
Neuropharmacology; 2017 Mar; 115():60-72. PubMed ID: 27392634
[TBL] [Abstract][Full Text] [Related]
12. Molecular Modeling Study of a Receptor-Orthosteric Ligand-Allosteric Modulator Signaling Complex.
Jiang C; He X; Wang Y; Chen CJ; Othman Y; Hao Y; Yuan J; Xie XQ; Feng Z
ACS Chem Neurosci; 2023 Feb; 14(3):418-434. PubMed ID: 36692197
[TBL] [Abstract][Full Text] [Related]
13. Role of the Second Extracellular Loop of the Adenosine A1 Receptor on Allosteric Modulator Binding, Signaling, and Cooperativity.
Nguyen AT; Vecchio EA; Thomas T; Nguyen TD; Aurelio L; Scammells PJ; White PJ; Sexton PM; Gregory KJ; May LT; Christopoulos A
Mol Pharmacol; 2016 Dec; 90(6):715-725. PubMed ID: 27683013
[TBL] [Abstract][Full Text] [Related]
14. Allosteric "beta-blocker" isolated from a DNA-encoded small molecule library.
Ahn S; Kahsai AW; Pani B; Wang QT; Zhao S; Wall AL; Strachan RT; Staus DP; Wingler LM; Sun LD; Sinnaeve J; Choi M; Cho T; Xu TT; Hansen GM; Burnett MB; Lamerdin JE; Bassoni DL; Gavino BJ; Husemoen G; Olsen EK; Franch T; Costanzi S; Chen X; Lefkowitz RJ
Proc Natl Acad Sci U S A; 2017 Feb; 114(7):1708-1713. PubMed ID: 28130548
[TBL] [Abstract][Full Text] [Related]
15. "Selective" Class C G Protein-Coupled Receptor Modulators Are Neutral or Biased mGlu
Hellyer SD; Albold S; Wang T; Chen ANY; May LT; Leach K; Gregory KJ
Mol Pharmacol; 2018 May; 93(5):504-514. PubMed ID: 29514854
[TBL] [Abstract][Full Text] [Related]
16. Analysis of equilibrium binding of an orthosteric tracer and two allosteric modulators.
Jakubík J; Randáková A; El-Fakahany EE; Doležal V
PLoS One; 2019; 14(3):e0214255. PubMed ID: 30917186
[TBL] [Abstract][Full Text] [Related]
17. Identification of Novel Allosteric Modulators of Metabotropic Glutamate Receptor Subtype 5 Acting at Site Distinct from 2-Methyl-6-(phenylethynyl)-pyridine Binding.
Butkiewicz M; Rodriguez AL; Rainey SE; Wieting J; Luscombe VB; Stauffer SR; Lindsley CW; Conn PJ; Meiler J
ACS Chem Neurosci; 2019 Aug; 10(8):3427-3436. PubMed ID: 31132237
[TBL] [Abstract][Full Text] [Related]
18. Identification of selective agonists and positive allosteric modulators for µ- and δ-opioid receptors from a single high-throughput screen.
Burford NT; Wehrman T; Bassoni D; O'Connell J; Banks M; Zhang L; Alt A
J Biomol Screen; 2014 Oct; 19(9):1255-65. PubMed ID: 25047277
[TBL] [Abstract][Full Text] [Related]
19. Development of a high throughput screen for allosteric modulators of melanocortin-4 receptor signaling using a real time cAMP assay.
Pantel J; Williams SY; Mi D; Sebag J; Corbin JD; Weaver CD; Cone RD
Eur J Pharmacol; 2011 Jun; 660(1):139-47. PubMed ID: 21296065
[TBL] [Abstract][Full Text] [Related]
20. High-Throughput Agonist Shift Assay Development for the Analysis of M
Homsher MF; Beshore DC; Cassaday J; Squadroni B; Mohammed E; Hartnett M; Day S; Ma L; Pechter D; Smith MD; Monsma F; Zuck P; Finley MF; Uebele VN; Hermes JD
SLAS Discov; 2017 Sep; 22(8):1060-1066. PubMed ID: 28426939
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
