BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

159 related articles for article (PubMed ID: 27671303)

  • 1. TGF-β Signal Transduction in Pancreatic Carcinoma Cells is Sensitive to Inhibition by the Src Tyrosine Kinase Inhibitor AZM475271.
    Bartscht T; Rosien B; Rades D; Kaufmann R; Biersack H; Lehnert H; Ungefroren H
    Anticancer Agents Med Chem; 2017; 17(7):966-972. PubMed ID: 27671303
    [TBL] [Abstract][Full Text] [Related]  

  • 2. The Src family kinase inhibitors PP2 and PP1 effectively block TGF-beta1-induced cell migration and invasion in both established and primary carcinoma cells.
    Bartscht T; Lehnert H; Gieseler F; Ungefroren H
    Cancer Chemother Pharmacol; 2012 Aug; 70(2):221-30. PubMed ID: 22699812
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Dasatinib blocks transcriptional and promigratory responses to transforming growth factor-beta in pancreatic adenocarcinoma cells through inhibition of Smad signalling: implications for in vivo mode of action.
    Bartscht T; Rosien B; Rades D; Kaufmann R; Biersack H; Lehnert H; Gieseler F; Ungefroren H
    Mol Cancer; 2015 Nov; 14():199. PubMed ID: 26588899
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Differential roles of Src in transforming growth factor-ß regulation of growth arrest, epithelial-to-mesenchymal transition and cell migration in pancreatic ductal adenocarcinoma cells.
    Ungefroren H; Sebens S; Groth S; Gieseler F; Fändrich F
    Int J Oncol; 2011 Mar; 38(3):797-805. PubMed ID: 21225226
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The Src family kinase inhibitors PP2 and PP1 block TGF-beta1-mediated cellular responses by direct and differential inhibition of type I and type II TGF-beta receptors.
    Ungefroren H; Sebens S; Groth S; Gieseler F; Fändrich F
    Curr Cancer Drug Targets; 2011 May; 11(4):524-35. PubMed ID: 21395548
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Inhibition of TGF-β Signaling in Tumor Cells by Small Molecule Src Family Kinase Inhibitors.
    Bartscht T; Rosien B; Rades D; Kaufmann R; Biersack H; Lehnerta H; Ungefroren H
    Anticancer Agents Med Chem; 2017; 17(10):1351-1356. PubMed ID: 28044939
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Rac1b negatively regulates TGF-β1-induced cell motility in pancreatic ductal epithelial cells by suppressing Smad signalling.
    Ungefroren H; Sebens S; Giehl K; Helm O; Groth S; Fändrich F; Röcken C; Sipos B; Lehnert H; Gieseler F
    Oncotarget; 2014 Jan; 5(1):277-90. PubMed ID: 24378395
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Differential roles of Smad2 and Smad3 in the regulation of TGF-β1-mediated growth inhibition and cell migration in pancreatic ductal adenocarcinoma cells: control by Rac1.
    Ungefroren H; Groth S; Sebens S; Lehnert H; Gieseler F; Fändrich F
    Mol Cancer; 2011 May; 10():67. PubMed ID: 21624123
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Proteinase-activated receptor 2 promotes TGF-β-dependent cell motility in pancreatic cancer cells by sustaining expression of the TGF-β type I receptor ALK5.
    Zeeh F; Witte D; Gädeken T; Rauch BH; Grage-Griebenow E; Leinung N; Fromm SJ; Stölting S; Mihara K; Kaufmann R; Settmacher U; Lehnert H; Hollenberg MD; Ungefroren H
    Oncotarget; 2016 Jul; 7(27):41095-41109. PubMed ID: 27248167
    [TBL] [Abstract][Full Text] [Related]  

  • 10. TGF-β1-induced cell migration in pancreatic carcinoma cells is RAC1 and NOX4-dependent and requires RAC1 and NOX4-dependent activation of p38 MAPK.
    Witte D; Bartscht T; Kaufmann R; Pries R; Settmacher U; Lehnert H; Ungefroren H
    Oncol Rep; 2017 Dec; 38(6):3693-3701. PubMed ID: 29039574
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Src activation is not necessary for transforming growth factor (TGF)-beta-mediated epithelial to mesenchymal transitions (EMT) in mammary epithelial cells. PP1 directly inhibits TGF-beta receptors I and II.
    Maeda M; Shintani Y; Wheelock MJ; Johnson KR
    J Biol Chem; 2006 Jan; 281(1):59-68. PubMed ID: 16267045
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Effect of Src kinase inhibition on metastasis and tumor angiogenesis in human pancreatic cancer.
    Ischenko I; Guba M; Yezhelyev M; Papyan A; Schmid G; Green T; Fennell M; Jauch KW; Bruns CJ
    Angiogenesis; 2007; 10(3):167-82. PubMed ID: 17486419
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Stem cell marker nestin is critical for TGF-β1-mediated tumor progression in pancreatic cancer.
    Su HT; Weng CC; Hsiao PJ; Chen LH; Kuo TL; Chen YW; Kuo KK; Cheng KH
    Mol Cancer Res; 2013 Jul; 11(7):768-79. PubMed ID: 23552743
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Dissecting the role of TGF-beta type I receptor/ALK5 in pancreatic ductal adenocarcinoma: Smad activation is crucial for both the tumor suppressive and prometastatic function.
    Schniewind B; Groth S; Sebens Müerköster S; Sipos B; Schäfer H; Kalthoff H; Fändrich F; Ungefroren H
    Oncogene; 2007 Jul; 26(33):4850-62. PubMed ID: 17297450
    [TBL] [Abstract][Full Text] [Related]  

  • 15. JAK/STAT3 signaling is required for TGF-β-induced epithelial-mesenchymal transition in lung cancer cells.
    Liu RY; Zeng Y; Lei Z; Wang L; Yang H; Liu Z; Zhao J; Zhang HT
    Int J Oncol; 2014 May; 44(5):1643-51. PubMed ID: 24573038
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Targeting endogenous transforming growth factor beta receptor signaling in SMAD4-deficient human pancreatic carcinoma cells inhibits their invasive phenotype1.
    Subramanian G; Schwarz RE; Higgins L; McEnroe G; Chakravarty S; Dugar S; Reiss M
    Cancer Res; 2004 Aug; 64(15):5200-11. PubMed ID: 15289325
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The Crosstalk between Nrf2 and TGF-β1 in the Epithelial-Mesenchymal Transition of Pancreatic Duct Epithelial Cells.
    Arfmann-Knübel S; Struck B; Genrich G; Helm O; Sipos B; Sebens S; Schäfer H
    PLoS One; 2015; 10(7):e0132978. PubMed ID: 26226105
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inhibition of SRC tyrosine kinase as treatment for human pancreatic cancer growing orthotopically in nude mice.
    Yezhelyev MV; Koehl G; Guba M; Brabletz T; Jauch KW; Ryan A; Barge A; Green T; Fennell M; Bruns CJ
    Clin Cancer Res; 2004 Dec; 10(23):8028-36. PubMed ID: 15585638
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Plasminogen activator inhibitor type-1 gene expression and induced migration in TGF-beta1-stimulated smooth muscle cells is pp60(c-src)/MEK-dependent.
    Samarakoon R; Higgins CE; Higgins SP; Kutz SM; Higgins PJ
    J Cell Physiol; 2005 Jul; 204(1):236-46. PubMed ID: 15622520
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Resveratrol suppresses epithelial-to-mesenchymal transition in colorectal cancer through TGF-β1/Smads signaling pathway mediated Snail/E-cadherin expression.
    Ji Q; Liu X; Han Z; Zhou L; Sui H; Yan L; Jiang H; Ren J; Cai J; Li Q
    BMC Cancer; 2015 Mar; 15():97. PubMed ID: 25884904
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.