156 related articles for article (PubMed ID: 27671499)
1. Tetrahydropyrazolo[4,3-c]pyridine derivatives as potent and peripherally selective cannabinoid-1 (CB1) receptor inverse agonists.
Zhu B; Matthews JM; Xia M; Black S; Chen C; Hou C; Liang Y; Tang Y; Macielag MJ
Bioorg Med Chem Lett; 2016 Nov; 26(22):5597-5601. PubMed ID: 27671499
[TBL] [Abstract][Full Text] [Related]
2. Differential effects of cannabinoid CB1 inverse agonists and antagonists on impulsivity in male Sprague Dawley rats: identification of a possibly clinically relevant vulnerability involving the serotonin 5HT
McLaughlin PJ; Jagielo-Miller JE; Plyler ES; Schutte KK; Vemuri VK; Makriyannis A
Psychopharmacology (Berl); 2017 Mar; 234(6):1029-1043. PubMed ID: 28144708
[TBL] [Abstract][Full Text] [Related]
3. Characterization of a novel, brain-penetrating CB1 receptor inverse agonist: metabolic profile in diet-induced obese models and aspects of central activity.
Jacobson LH; Commerford SR; Gerber SP; Chen YA; Dardik B; Chaperon F; Schwartzkopf C; Nguyen-Tran V; Hollenbeck T; McNamara P; He X; Liu H; Seidel HM; Jaton AL; Gromada J; Teixeira S
Naunyn Schmiedebergs Arch Pharmacol; 2011 Dec; 384(6):565-81. PubMed ID: 21947251
[TBL] [Abstract][Full Text] [Related]
4. Tetrahydroindazole derivatives as potent and peripherally selective cannabinoid-1 (CB1) receptor inverse agonists.
Matthews JM; McNally JJ; Connolly PJ; Xia M; Zhu B; Black S; Chen C; Hou C; Liang Y; Tang Y; Macielag MJ
Bioorg Med Chem Lett; 2016 Nov; 26(21):5346-5349. PubMed ID: 27671496
[TBL] [Abstract][Full Text] [Related]
5. Pyrazole antagonists of the CB1 receptor with reduced brain penetration.
Fulp A; Zhang Y; Bortoff K; Seltzman H; Snyder R; Wiethe R; Amato G; Maitra R
Bioorg Med Chem; 2016 Mar; 24(5):1063-70. PubMed ID: 26827137
[TBL] [Abstract][Full Text] [Related]
6. Second generation CB1 receptor blockers and other inhibitors of peripheral endocannabinoid overactivity and the rationale of their use against metabolic disorders.
Silvestri C; Di Marzo V
Expert Opin Investig Drugs; 2012 Sep; 21(9):1309-22. PubMed ID: 22780328
[TBL] [Abstract][Full Text] [Related]
7. Controlled downregulation of the cannabinoid CB1 receptor provides a promising approach for the treatment of obesity and obesity-derived type 2 diabetes.
Lu D; Dopart R; Kendall DA
Cell Stress Chaperones; 2016 Jan; 21(1):1-7. PubMed ID: 26498013
[TBL] [Abstract][Full Text] [Related]
8. Peripherally restricted CB1 receptor blockers.
Chorvat RJ
Bioorg Med Chem Lett; 2013 Sep; 23(17):4751-60. PubMed ID: 23902803
[TBL] [Abstract][Full Text] [Related]
9. Prospective therapeutic agents for obesity: molecular modification approaches of centrally and peripherally acting selective cannabinoid 1 receptor antagonists.
Sharma MK; Murumkar PR; Kanhed AM; Giridhar R; Yadav MR
Eur J Med Chem; 2014 May; 79():298-339. PubMed ID: 24747288
[TBL] [Abstract][Full Text] [Related]
10. Fluorine-18 isotope labeling for positron emission tomography imaging. Direct evidence for DBPR211 as a peripherally restricted CB1 inverse agonist.
Chang CP; Huang HL; Huang JK; Hung MS; Wu CH; Song JS; Lee CJ; Yu CS; Shia KS
Bioorg Med Chem; 2019 Jan; 27(1):216-223. PubMed ID: 30528163
[TBL] [Abstract][Full Text] [Related]
11. Contrasting effects of different cannabinoid receptor ligands on mouse ingestive behaviour.
Grey J; Terry P; Higgs S
Behav Pharmacol; 2012 Sep; 23(5-6):551-9. PubMed ID: 22772336
[TBL] [Abstract][Full Text] [Related]
12. Functionalized 6-(Piperidin-1-yl)-8,9-Diphenyl Purines as Peripherally Restricted Inverse Agonists of the CB1 Receptor.
Amato G; Manke A; Wiethe R; Vasukuttan V; Snyder R; Yueh YL; Decker A; Runyon S; Maitra R
J Med Chem; 2019 Jul; 62(13):6330-6345. PubMed ID: 31185168
[TBL] [Abstract][Full Text] [Related]
13. Diphenyl purine derivatives as peripherally selective cannabinoid receptor 1 antagonists.
Fulp A; Bortoff K; Zhang Y; Seltzman H; Mathews J; Snyder R; Fennell T; Maitra R
J Med Chem; 2012 Nov; 55(22):10022-32. PubMed ID: 23098108
[TBL] [Abstract][Full Text] [Related]
14. Overcoming the Psychiatric Side Effects of the Cannabinoid CB1 Receptor Antagonists: Current Approaches for Therapeutics Development.
Nguyen T; Thomas BF; Zhang Y
Curr Top Med Chem; 2019; 19(16):1418-1435. PubMed ID: 31284863
[TBL] [Abstract][Full Text] [Related]
15. Novel effects of the cannabinoid inverse agonist AM 251 on parameters related to metabolic syndrome in obese Zucker rats.
Merroun I; Sánchez-González C; Martínez R; López-Chaves C; Porres JM; Aranda P; Llopis J; Galisteo M; Zarzuelo A; Errami M; López-Jurado M
Metabolism; 2013 Nov; 62(11):1641-50. PubMed ID: 23932644
[TBL] [Abstract][Full Text] [Related]
16. Peripheral selectivity of the novel cannabinoid receptor antagonist TM38837 in healthy subjects.
Klumpers LE; Fridberg M; de Kam ML; Little PB; Jensen NO; Kleinloog HD; Elling CE; van Gerven JM
Br J Clin Pharmacol; 2013 Dec; 76(6):846-57. PubMed ID: 23601084
[TBL] [Abstract][Full Text] [Related]
17. NESS038C6, a novel selective CB1 antagonist agent with anti-obesity activity and improved molecular profile.
Mastinu A; Pira M; Pani L; Pinna GA; Lazzari P
Behav Brain Res; 2012 Oct; 234(2):192-204. PubMed ID: 22771813
[TBL] [Abstract][Full Text] [Related]
18. Reports of the death of CB1 antagonists have been greatly exaggerated: recent preclinical findings predict improved safety in the treatment of obesity.
McLaughlin PJ
Behav Pharmacol; 2012 Sep; 23(5-6):537-50. PubMed ID: 22743603
[TBL] [Abstract][Full Text] [Related]
19. Synthesis, Biological Evaluation, and Molecular Modeling Studies of 3,4-Diarylpyrazoline Series of Compounds as Potent, Nonbrain Penetrant Antagonists of Cannabinoid-1 (CB
Iyer MR; Cinar R; Wood CM; Zawatsky CN; Coffey NJ; Kim KA; Liu Z; Katz A; Abdalla J; Hassan SA; Lee YS
J Med Chem; 2022 Feb; 65(3):2374-2387. PubMed ID: 35084860
[TBL] [Abstract][Full Text] [Related]
20. Blocking Alcoholic Steatosis in Mice with a Peripherally Restricted Purine Antagonist of the Type 1 Cannabinoid Receptor.
Amato GS; Manke A; Harris DL; Wiethe RW; Vasukuttan V; Snyder RW; Lefever TW; Cortes R; Zhang Y; Wang S; Runyon SP; Maitra R
J Med Chem; 2018 May; 61(10):4370-4385. PubMed ID: 29688015
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]
