These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

166 related articles for article (PubMed ID: 27708405)

  • 1. A fragment-based approach applied to a highly flexible target: Insights and challenges towards the inhibition of HSP70 isoforms.
    Jones AM; Westwood IM; Osborne JD; Matthews TP; Cheeseman MD; Rowlands MG; Jeganathan F; Burke R; Lee D; Kadi N; Liu M; Richards M; McAndrew C; Yahya N; Dobson SE; Jones K; Workman P; Collins I; van Montfort RL
    Sci Rep; 2016 Oct; 6():34701. PubMed ID: 27708405
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Discovery and Characterization of a Cryptic Secondary Binding Site in the Molecular Chaperone HSP70.
    O'Connor S; Le Bihan YV; Westwood IM; Liu M; Mak OW; Zazeri G; Povinelli APR; Jones AM; van Montfort R; Reynisson J; Collins I
    Molecules; 2022 Jan; 27(3):. PubMed ID: 35164081
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Allosteric opening of the polypeptide-binding site when an Hsp70 binds ATP.
    Qi R; Sarbeng EB; Liu Q; Le KQ; Xu X; Xu H; Yang J; Wong JL; Vorvis C; Hendrickson WA; Zhou L; Liu Q
    Nat Struct Mol Biol; 2013 Jul; 20(7):900-7. PubMed ID: 23708608
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Human Hsp70 molecular chaperone binds two calcium ions within the ATPase domain.
    Sriram M; Osipiuk J; Freeman B; Morimoto R; Joachimiak A
    Structure; 1997 Mar; 5(3):403-14. PubMed ID: 9083109
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structural and functional characterization of the chaperone Hsp70 from sugarcane. Insights into conformational changes during cycling from cross-linking/mass spectrometry assays.
    Tiroli-Cepeda AO; Lima TB; Balbuena TS; Gozzo FC; Ramos CH
    J Proteomics; 2014 Jun; 104():48-56. PubMed ID: 24530624
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Hsp70 chaperone dynamics and molecular mechanism.
    Mayer MP
    Trends Biochem Sci; 2013 Oct; 38(10):507-14. PubMed ID: 24012426
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Conformational equilibria in allosteric control of Hsp70 chaperones.
    Wang W; Liu Q; Liu Q; Hendrickson WA
    Mol Cell; 2021 Oct; 81(19):3919-3933.e7. PubMed ID: 34453889
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Structural basis for the cooperation of Hsp70 and Hsp110 chaperones in protein folding.
    Polier S; Dragovic Z; Hartl FU; Bracher A
    Cell; 2008 Jun; 133(6):1068-79. PubMed ID: 18555782
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Hsp70 chaperones: cellular functions and molecular mechanism.
    Mayer MP; Bukau B
    Cell Mol Life Sci; 2005 Mar; 62(6):670-84. PubMed ID: 15770419
    [TBL] [Abstract][Full Text] [Related]  

  • 10. ATP-induced conformational changes in Hsp70: molecular dynamics and experimental validation of an in silico predicted conformation.
    Woo HJ; Jiang J; Lafer EM; Sousa R
    Biochemistry; 2009 Dec; 48(48):11470-7. PubMed ID: 19883127
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Structure Based Design of a Grp94-Selective Inhibitor: Exploiting a Key Residue in Grp94 To Optimize Paralog-Selective Binding.
    Que NLS; Crowley VM; Duerfeldt AS; Zhao J; Kent CN; Blagg BSJ; Gewirth DT
    J Med Chem; 2018 Apr; 61(7):2793-2805. PubMed ID: 29528635
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Mapping the role of active site residues for transducing an ATP-induced conformational change in the bovine 70-kDa heat shock cognate protein.
    Johnson ER; McKay DB
    Biochemistry; 1999 Aug; 38(33):10823-30. PubMed ID: 10451379
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structure and dynamics of the ATP-bound open conformation of Hsp70 chaperones.
    Kityk R; Kopp J; Sinning I; Mayer MP
    Mol Cell; 2012 Dec; 48(6):863-74. PubMed ID: 23123194
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Structure of a Bag/Hsc70 complex: convergent functional evolution of Hsp70 nucleotide exchange factors.
    Sondermann H; Scheufler C; Schneider C; Hohfeld J; Hartl FU; Moarefi I
    Science; 2001 Feb; 291(5508):1553-7. PubMed ID: 11222862
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Conformation transitions of the polypeptide-binding pocket support an active substrate release from Hsp70s.
    Yang J; Zong Y; Su J; Li H; Zhu H; Columbus L; Zhou L; Liu Q
    Nat Commun; 2017 Oct; 8(1):1201. PubMed ID: 29084938
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Mapping the conformation of a client protein through the Hsp70 functional cycle.
    Sekhar A; Rosenzweig R; Bouvignies G; Kay LE
    Proc Natl Acad Sci U S A; 2015 Aug; 112(33):10395-400. PubMed ID: 26240333
    [TBL] [Abstract][Full Text] [Related]  

  • 17. (-)-Epigallocatechin-3-Gallate Inhibits the Chaperone Activity of Plasmodium falciparum Hsp70 Chaperones and Abrogates Their Association with Functional Partners.
    Zininga T; Ramatsui L; Makhado PB; Makumire S; Achilinou I; Hoppe H; Dirr H; Shonhai A
    Molecules; 2017 Dec; 22(12):. PubMed ID: 29206141
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Insights into Hsp70 chaperone activity from a crystal structure of the yeast Hsp110 Sse1.
    Liu Q; Hendrickson WA
    Cell; 2007 Oct; 131(1):106-20. PubMed ID: 17923091
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Intra-molecular pathways of allosteric control in Hsp70s.
    Mayer MP
    Philos Trans R Soc Lond B Biol Sci; 2018 Jun; 373(1749):. PubMed ID: 29735737
    [TBL] [Abstract][Full Text] [Related]  

  • 20. NMR study of nucleotide-induced changes in the nucleotide binding domain of Thermus thermophilus Hsp70 chaperone DnaK: implications for the allosteric mechanism.
    Revington M; Holder TM; Zuiderweg ER
    J Biol Chem; 2004 Aug; 279(32):33958-67. PubMed ID: 15175340
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.