BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

190 related articles for article (PubMed ID: 27718639)

  • 1. Perspective: 4β-hydroxycholesterol as an emerging endogenous biomarker of hepatic CYP3A.
    Mao J; Martin I; McLeod J; Nolan G; van Horn R; Vourvahis M; Lin YS
    Drug Metab Rev; 2017 Feb; 49(1):18-34. PubMed ID: 27718639
    [TBL] [Abstract][Full Text] [Related]  

  • 2. 4β-Hydroxycholesterol as an Endogenous Biomarker for CYP3A Activity: Literature Review and Critical Evaluation.
    Penzak SR; Rojas-Fernandez C
    J Clin Pharmacol; 2019 May; 59(5):611-624. PubMed ID: 30748026
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Quinine compared to 4β-hydroxycholesterol and midazolam as markers for CYP3A induction by rifampicin.
    Björkhem-Bergman L; Bäckström T; Nylén H; Rönquist-Nii Y; Bredberg E; Andersson TB; Bertilsson L; Diczfalusy U
    Drug Metab Pharmacokinet; 2014; 29(4):352-5. PubMed ID: 24522201
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Evaluation of 4β-Hydroxycholesterol and 25-Hydroxycholesterol as Endogenous Biomarkers of CYP3A4: Study with CYP3A-Humanized Mice.
    Nitta SI; Hashimoto M; Kazuki Y; Takehara S; Suzuki H; Oshimura M; Akita H; Chiba K; Kobayashi K
    AAPS J; 2018 Apr; 20(3):61. PubMed ID: 29858698
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Validation of 4β-hydroxycholesterol and evaluation of other endogenous biomarkers for the assessment of CYP3A activity in healthy subjects.
    Kasichayanula S; Boulton DW; Luo WL; Rodrigues AD; Yang Z; Goodenough A; Lee M; Jemal M; LaCreta F
    Br J Clin Pharmacol; 2014 Nov; 78(5):1122-34. PubMed ID: 24837659
    [TBL] [Abstract][Full Text] [Related]  

  • 6. A comparative study for detecting CYP3A induction by CYP3A probe drugs and endogenous markers in cynomolgus monkeys.
    Tahara H; Watanabe M; Hasegawa M
    Biopharm Drug Dispos; 2019 Feb; 40(2):81-93. PubMed ID: 30724384
    [TBL] [Abstract][Full Text] [Related]  

  • 7. 4β-Hydroxycholesterol as an endogenous biomarker of CYP3A activity in cynomolgus monkeys.
    Li K; Zhao S; Zhang L; Wu X; Shu P; Wang Y; Feng H; Gu Z; Han Hsu H
    Drug Metab Dispos; 2014 May; 42(5):839-43. PubMed ID: 24595680
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Recommendations on the Development of a Bioanalytical Assay for 4β-Hydroxycholesterol, an Emerging Endogenous Biomarker of CYP3A Activity.
    Aubry AF; Dean B; Diczfalusy U; Goodenough A; Iffland A; McLeod J; Weng N; Yang Z
    AAPS J; 2016 Sep; 18(5):1056-1066. PubMed ID: 27350147
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Relationships between Endogenous Plasma Biomarkers of Constitutive Cytochrome P450 3A Activity and Single-Time-Point Oral Midazolam Microdose Phenotype in Healthy Subjects.
    Woolsey SJ; Beaton MD; Choi YH; Dresser GK; Gryn SE; Kim RB; Tirona RG
    Basic Clin Pharmacol Toxicol; 2016 Apr; 118(4):284-91. PubMed ID: 26399557
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Use of 4β-Hydroxycholesterol Plasma Concentrations as an Endogenous Biomarker of CYP3A Activity: Clinical Validation in Individuals With Type 2 Diabetes.
    Gravel S; Chiasson JL; Gaudette F; Turgeon J; Michaud V
    Clin Pharmacol Ther; 2019 Oct; 106(4):831-840. PubMed ID: 31002385
    [TBL] [Abstract][Full Text] [Related]  

  • 11. 4β-Hydroxycholesterol, an endogenous marker of CYP3A4/5 activity in humans.
    Diczfalusy U; Nylén H; Elander P; Bertilsson L
    Br J Clin Pharmacol; 2011 Feb; 71(2):183-9. PubMed ID: 21219398
    [TBL] [Abstract][Full Text] [Related]  

  • 12. CYP3A induction and inhibition by different antiretroviral regimens reflected by changes in plasma 4beta-hydroxycholesterol levels.
    Josephson F; Bertilsson L; Böttiger Y; Flamholc L; Gisslén M; Ormaasen V; Sönnerborg A; Diczfalusy U
    Eur J Clin Pharmacol; 2008 Aug; 64(8):775-81. PubMed ID: 18458892
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Formation of CYP3A-specific metabolites of ibrutinib in vitro is correlated with hepatic CYP3A activity and 4β-hydroxycholesterol/cholesterol ratio.
    Lee J; Fallon JK; Smith PC; Jackson KD
    Clin Transl Sci; 2023 Feb; 16(2):279-291. PubMed ID: 36350327
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Quantitation of P450 3A4 endogenous biomarker - 4β-hydroxycholesterol - in human plasma using LC/ESI-MS/MS.
    Huang MQ; Lin W; Wang W; Zhang W; Lin ZJ; Weng N
    Biomed Chromatogr; 2014 Jun; 28(6):794-801. PubMed ID: 24861746
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Effect of Statin Treatment on Plasma 4β-Hydroxycholesterol Concentrations.
    Björkhem-Bergman L; Nylén H; Eriksson M; Parini P; Diczfalusy U
    Basic Clin Pharmacol Toxicol; 2016 Jun; 118(6):499-502. PubMed ID: 26617265
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Assessment of induced CYP3A activity in pregnant women using 4β-hydroxycholesterol: Cholesterol ratio as an appropriate metabolic marker.
    Kim AH; Kim B; Rhee SJ; Lee Y; Park JS; Lee SM; Kim SM; Lee S; Yu KS; Jang IJ; Cho JY
    Drug Metab Pharmacokinet; 2018 Jun; 33(3):173-178. PubMed ID: 29759884
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Comparison of endogenous 4β-hydroxycholesterol with midazolam as markers for CYP3A4 induction by rifampicin.
    Björkhem-Bergman L; Bäckström T; Nylén H; Rönquist-Nii Y; Bredberg E; Andersson TB; Bertilsson L; Diczfalusy U
    Drug Metab Dispos; 2013 Aug; 41(8):1488-93. PubMed ID: 23674608
    [TBL] [Abstract][Full Text] [Related]  

  • 18. CYP3A activity based on plasma 4β-hydroxycholesterol during the early postpartum period has an effect on the plasma disposition of amlodipine.
    Naito T; Kubono N; Ishida T; Deguchi S; Sugihara M; Itoh H; Kanayama N; Kawakami J
    Drug Metab Pharmacokinet; 2015 Dec; 30(6):419-24. PubMed ID: 26654672
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Clinical Evaluation Based on a New Approach to Improve the Accuracy of 4β-Hydroxycholesterol Measurement as a Biomarker of CYP3A4 Activity.
    Taya Y; Mizunaga M; Nakao S; Jutanom M; Shimizu N; Nomura Y; Nakagawa K
    Molecules; 2023 Feb; 28(4):. PubMed ID: 36838563
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Urinary 6β-Hydroxycortisol/Cortisol Ratio Most Highly Correlates With Midazolam Clearance Under Hepatic CYP3A Inhibition and Induction in Females: A Pharmacometabolomics Approach.
    Shin KH; Ahn LY; Choi MH; Moon JY; Lee J; Jang IJ; Yu KS; Cho JY
    AAPS J; 2016 Sep; 18(5):1254-1261. PubMed ID: 27317471
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.