These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

147 related articles for article (PubMed ID: 27722252)

  • 1. Picolinic acids as β-exosite inhibitors of botulinum neurotoxin A light chain.
    Bremer PT; Xue S; Janda KD
    Chem Commun (Camb); 2016 Oct; 52(84):12521-12524. PubMed ID: 27722252
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Benzoquinones as inhibitors of botulinum neurotoxin serotype A.
    Bremer PT; Hixon MS; Janda KD
    Bioorg Med Chem; 2014 Aug; 22(15):3971-81. PubMed ID: 24984937
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Probing BoNT/A protease exosites: implications for inhibitor design and light chain longevity.
    Xue S; Javor S; Hixon MS; Janda KD
    Biochemistry; 2014 Nov; 53(43):6820-4. PubMed ID: 25295706
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Synthesis and activity of isoleucine sulfonamide derivatives as novel botulinum neurotoxin serotype A light chain inhibitors.
    Thompson JC; Dao WT; Ku A; Rodriguez-Beltran SL; Amezcua M; Palomino AY; Lien T; Salzameda NT
    Bioorg Med Chem; 2020 Sep; 28(18):115659. PubMed ID: 32828426
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Synthesis and evaluation of library of betulin derivatives against the botulinum neurotoxin A protease.
    Šilhár P; Alakurtti S; Čapková K; Xiaochuan F; Shoemaker CB; Yli-Kauhaluoma J; Janda KD
    Bioorg Med Chem Lett; 2011 Apr; 21(8):2229-31. PubMed ID: 21421315
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structural insight into exosite binding and discovery of novel exosite inhibitors of botulinum neurotoxin serotype A through in silico screening.
    Hu X; Legler PM; Southall N; Maloney DJ; Simeonov A; Jadhav A
    J Comput Aided Mol Des; 2014 Jul; 28(7):765-78. PubMed ID: 24958623
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Time-dependent botulinum neurotoxin serotype A metalloprotease inhibitors.
    Li B; Cardinale SC; Butler MM; Pai R; Nuss JE; Peet NP; Bavari S; Bowlin TL
    Bioorg Med Chem; 2011 Dec; 19(24):7338-48. PubMed ID: 22082667
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Examination of α-exosite inhibitors against Botulinum neurotoxin A protease through structure-activity relationship studies of chicoric acid.
    Xue S; Seki H; Remes M; Šilhár P; Janda K
    Bioorg Med Chem Lett; 2017 Nov; 27(22):4956-4959. PubMed ID: 29050781
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Chirality holds the key for potent inhibition of the botulinum neurotoxin serotype a protease.
    Stowe GN; Silhár P; Hixon MS; Silvaggi NR; Allen KN; Moe ST; Jacobson AR; Barbieri JT; Janda KD
    Org Lett; 2010 Feb; 12(4):756-9. PubMed ID: 20092262
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Synthesis/biological evaluation of hydroxamic acids and their prodrugs as inhibitors for Botulinum neurotoxin A light chain.
    Seki H; Pellett S; Silhár P; Stowe GN; Blanco B; Lardy MA; Johnson EA; Janda KD
    Bioorg Med Chem; 2014 Feb; 22(3):1208-17. PubMed ID: 24360826
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Metal Ions Effectively Ablate the Action of Botulinum Neurotoxin A.
    Bremer PT; Pellett S; Carolan JP; Tepp WH; Eubanks LM; Allen KN; Johnson EA; Janda KD
    J Am Chem Soc; 2017 May; 139(21):7264-7272. PubMed ID: 28475321
    [TBL] [Abstract][Full Text] [Related]  

  • 12. 8-Hydroxyquinoline and hydroxamic acid inhibitors of botulinum neurotoxin BoNT/A.
    Dickerson TJ; Smith GR; Pelletier JC; Reitz AB
    Curr Top Med Chem; 2014; 14(18):2094-102. PubMed ID: 25335884
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Botulinum neurotoxin A protease: discovery of natural product exosite inhibitors.
    Silhár P; Capková K; Salzameda NT; Barbieri JT; Hixon MS; Janda KD
    J Am Chem Soc; 2010 Mar; 132(9):2868-9. PubMed ID: 20158239
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Reexamining hydroxamate inhibitors of botulinum neurotoxin serotype A: extending towards the β-exosite.
    Smith GR; Caglič D; Capek P; Zhang Y; Godbole S; Reitz AB; Dickerson TJ
    Bioorg Med Chem Lett; 2012 Jun; 22(11):3754-7. PubMed ID: 22542019
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Strategies to Counteract Botulinum Neurotoxin A: Nature's Deadliest Biomolecule.
    Lin L; Olson ME; Eubanks LM; Janda KD
    Acc Chem Res; 2019 Aug; 52(8):2322-2331. PubMed ID: 31322847
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The synthesis of 2,5-bis(4-amidinophenyl)thiophene derivatives providing submicromolar-range inhibition of the botulinum neurotoxin serotype A metalloprotease.
    Opsenica I; Filipovic V; Nuss JE; Gomba LM; Opsenica D; Burnett JC; Gussio R; Solaja BA; Bavari S
    Eur J Med Chem; 2012 Jul; 53():374-9. PubMed ID: 22516424
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Structural characterization of three novel hydroxamate-based zinc chelating inhibitors of the Clostridium botulinum serotype A neurotoxin light chain metalloprotease reveals a compact binding site resulting from 60/70 loop flexibility.
    Thompson AA; Jiao GS; Kim S; Thai A; Cregar-Hernandez L; Margosiak SA; Johnson AT; Han GW; O'Malley S; Stevens RC
    Biochemistry; 2011 May; 50(19):4019-28. PubMed ID: 21434688
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Evaluation of adamantane hydroxamates as botulinum neurotoxin inhibitors: synthesis, crystallography, modeling, kinetic and cellular based studies.
    Šilhár P; Silvaggi NR; Pellett S; Čapková K; Johnson EA; Allen KN; Janda KD
    Bioorg Med Chem; 2013 Mar; 21(5):1344-8. PubMed ID: 23340139
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Small molecule metalloprotease inhibitor with in vitro, ex vivo and in vivo efficacy against botulinum neurotoxin serotype A.
    Jacobson AR; Adler M; Silvaggi NR; Allen KN; Smith GM; Fredenburg RA; Stein RL; Park JB; Feng X; Shoemaker CB; Deshpande SS; Goodnough MC; Malizio CJ; Johnson EA; Pellett S; Tepp WH; Tzipori S
    Toxicon; 2017 Oct; 137():36-47. PubMed ID: 28698055
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Camelid VHH Antibodies that Neutralize Botulinum Neurotoxin Serotype E Intoxication or Protease Function.
    Tremblay JM; Vazquez-Cintron E; Lam KH; Mukherjee J; Bedenice D; Ondeck CA; Conroy MT; Bodt SML; Winner BM; Webb RP; Ichtchenko K; Jin R; McNutt PM; Shoemaker CB
    Toxins (Basel); 2020 Sep; 12(10):. PubMed ID: 32987745
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 8.