BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

356 related articles for article (PubMed ID: 27729194)

  • 1. VCP inhibitors induce endoplasmic reticulum stress, cause cell cycle arrest, trigger caspase-mediated cell death and synergistically kill ovarian cancer cells in combination with Salubrinal.
    Bastola P; Neums L; Schoenen FJ; Chien J
    Mol Oncol; 2016 Dec; 10(10):1559-1574. PubMed ID: 27729194
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Sorafenib-mediated targeting of the AAA⁺ ATPase p97/VCP leads to disruption of the secretory pathway, endoplasmic reticulum stress, and hepatocellular cancer cell death.
    Yi P; Higa A; Taouji S; Bexiga MG; Marza E; Arma D; Castain C; Le Bail B; Simpson JC; Rosenbaum J; Balabaud C; Bioulac-Sage P; Blanc JF; Chevet E
    Mol Cancer Ther; 2012 Dec; 11(12):2610-20. PubMed ID: 23041544
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Dendrimer-Based Selective Proteostasis-Inhibition Strategy to Control NSCLC Growth and Progression.
    Walworth K; Bodas M; Campbell RJ; Swanson D; Sharma A; Vij N
    PLoS One; 2016; 11(7):e0158507. PubMed ID: 27434122
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Structure-activity relationship study reveals ML240 and ML241 as potent and selective inhibitors of p97 ATPase.
    Chou TF; Li K; Frankowski KJ; Schoenen FJ; Deshaies RJ
    ChemMedChem; 2013 Feb; 8(2):297-312. PubMed ID: 23316025
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Novel p97/VCP inhibitor induces endoplasmic reticulum stress and apoptosis in both bortezomib-sensitive and -resistant multiple myeloma cells.
    Nishimura N; Radwan MO; Amano M; Endo S; Fujii E; Hayashi H; Ueno S; Ueno N; Tatetsu H; Hata H; Okamoto Y; Otsuka M; Mitsuya H; Matsuoka M; Okuno Y
    Cancer Sci; 2019 Oct; 110(10):3275-3287. PubMed ID: 31368616
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Synergistic apoptosis induction in leukemic cells by the phosphatase inhibitor salubrinal and proteasome inhibitors.
    Drexler HC
    PLoS One; 2009; 4(1):e4161. PubMed ID: 19129918
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Disruption of p97/VCP induces autophagosome accumulation, cell cycle arrest and apoptosis in human choriocarcinoma cells.
    Desdicioglu R; Sahin C; Yavuz F; Cayli S
    Mol Biol Rep; 2021 Mar; 48(3):2163-2171. PubMed ID: 33620660
    [TBL] [Abstract][Full Text] [Related]  

  • 8. VCP/p97/Cdc48, A Linking of Protein Homeostasis and Cancer Therapy.
    Lan B; Chai S; Wang P; Wang K
    Curr Mol Med; 2017; 17(9):608-618. PubMed ID: 29521227
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Interaction between salt-inducible kinase 2 (SIK2) and p97/valosin-containing protein (VCP) regulates endoplasmic reticulum (ER)-associated protein degradation in mammalian cells.
    Yang FC; Lin YH; Chen WH; Huang JY; Chang HY; Su SH; Wang HT; Chiang CY; Hsu PH; Tsai MD; Tan BC; Lee SC
    J Biol Chem; 2013 Nov; 288(47):33861-33872. PubMed ID: 24129571
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Valosin-containing protein (p97) is a regulator of endoplasmic reticulum stress and of the degradation of N-end rule and ubiquitin-fusion degradation pathway substrates in mammalian cells.
    Wójcik C; Rowicka M; Kudlicki A; Nowis D; McConnell E; Kujawa M; DeMartino GN
    Mol Biol Cell; 2006 Nov; 17(11):4606-18. PubMed ID: 16914519
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Endoplasmic Reticulum Stress Plays a Key Role in Rotenone-Induced Apoptotic Death of Neurons.
    Goswami P; Gupta S; Biswas J; Joshi N; Swarnkar S; Nath C; Singh S
    Mol Neurobiol; 2016 Jan; 53(1):285-298. PubMed ID: 25428620
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Covalent and allosteric inhibitors of the ATPase VCP/p97 induce cancer cell death.
    Magnaghi P; D'Alessio R; Valsasina B; Avanzi N; Rizzi S; Asa D; Gasparri F; Cozzi L; Cucchi U; Orrenius C; Polucci P; Ballinari D; Perrera C; Leone A; Cervi G; Casale E; Xiao Y; Wong C; Anderson DJ; Galvani A; Donati D; O'Brien T; Jackson PK; Isacchi A
    Nat Chem Biol; 2013 Sep; 9(9):548-56. PubMed ID: 23892893
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Pharmacological targeting of valosin containing protein (VCP) induces DNA damage and selectively kills canine lymphoma cells.
    Nadeau MÈ; Rico C; Tsoi M; Vivancos M; Filimon S; Paquet M; Boerboom D
    BMC Cancer; 2015 Jun; 15():479. PubMed ID: 26104798
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Pathogenic Mutations in the Valosin-containing Protein/p97(VCP) N-domain Inhibit the SUMOylation of VCP and Lead to Impaired Stress Response.
    Wang T; Xu W; Qin M; Yang Y; Bao P; Shen F; Zhang Z; Xu J
    J Biol Chem; 2016 Jul; 291(27):14373-14384. PubMed ID: 27226613
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Valosin-Containing Protein (VCP)/p97: A Prognostic Biomarker and Therapeutic Target in Cancer.
    Costantini S; Capone F; Polo A; Bagnara P; Budillon A
    Int J Mol Sci; 2021 Sep; 22(18):. PubMed ID: 34576340
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Salubrinal offers neuroprotection through suppressing endoplasmic reticulum stress, autophagy and apoptosis in a mouse traumatic brain injury model.
    Wang ZF; Gao C; Chen W; Gao Y; Wang HC; Meng Y; Luo CL; Zhang MY; Chen G; Chen XP; Wang T; Tao LY
    Neurobiol Learn Mem; 2019 May; 161():12-25. PubMed ID: 30851432
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Mifepristone increases mRNA translation rate, triggers the unfolded protein response, increases autophagic flux, and kills ovarian cancer cells in combination with proteasome or lysosome inhibitors.
    Zhang L; Hapon MB; Goyeneche AA; Srinivasan R; Gamarra-Luques CD; Callegari EA; Drappeau DD; Terpstra EJ; Pan B; Knapp JR; Chien J; Wang X; Eyster KM; Telleria CM
    Mol Oncol; 2016 Aug; 10(7):1099-117. PubMed ID: 27233943
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Selenoprotein S-dependent Selenoprotein K Binding to p97(VCP) Protein Is Essential for Endoplasmic Reticulum-associated Degradation.
    Lee JH; Park KJ; Jang JK; Jeon YH; Ko KY; Kwon JH; Lee SR; Kim IY
    J Biol Chem; 2015 Dec; 290(50):29941-52. PubMed ID: 26504085
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Functional ATPase activity of p97/valosin-containing protein (VCP) is required for the quality control of endoplasmic reticulum in neuronally differentiated mammalian PC12 cells.
    Kobayashi T; Tanaka K; Inoue K; Kakizuka A
    J Biol Chem; 2002 Dec; 277(49):47358-65. PubMed ID: 12351637
    [TBL] [Abstract][Full Text] [Related]  

  • 20. UV-induced proteolysis of RNA polymerase II is mediated by VCP/p97 segregase and timely orchestration by Cockayne syndrome B protein.
    He J; Zhu Q; Wani G; Wani AA
    Oncotarget; 2017 Feb; 8(7):11004-11019. PubMed ID: 28036256
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 18.