BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

176 related articles for article (PubMed ID: 27750031)

  • 1. Modulation of topoisomerase IIα expression and chemosensitivity through targeted inhibition of NF-Y:DNA binding by a diamino p-anisyl-benzimidazole (Hx) polyamide.
    Pett L; Kiakos K; Satam V; Patil P; Laughlin-Toth S; Gregory M; Bowerman M; Olson K; Savagian M; Lee M; Lee M; Wilson WD; Hochhauser D; Hartley JA
    Biochim Biophys Acta Gene Regul Mech; 2017 May; 1860(5):617-629. PubMed ID: 27750031
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Modulation of topoisomerase IIalpha expression by a DNA sequence-specific polyamide.
    Hochhauser D; Kotecha M; O'hare C; Morris PJ; Hartley JM; Taherbhai Z; Harris D; Forni C; Mantovani R; Lee M; Hartley JA
    Mol Cancer Ther; 2007 Jan; 6(1):346-54. PubMed ID: 17237293
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Nuclear Localization and Gene Expression Modulation by a Fluorescent Sequence-Selective p-Anisyl-benzimidazolecarboxamido Imidazole-Pyrrole Polyamide.
    Kiakos K; Pett L; Satam V; Patil P; Hochhauser D; Lee M; Hartley JA
    Chem Biol; 2015 Jul; 22(7):862-75. PubMed ID: 26119998
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Targeting the inverted CCAAT box 2 in the topoisomerase IIalpha promoter by JH-37, an imidazole-pyrrole polyamide hairpin: design, synthesis, molecular biology, and biophysical studies.
    Henry JA; Le NM; Nguyen B; Howard CM; Bailey SL; Horick SM; Buchmueller KL; Kotecha M; Hochhauser D; Hartley JA; Wilson WD; Lee M
    Biochemistry; 2004 Sep; 43(38):12249-57. PubMed ID: 15379563
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Nuclear factor-Y binding to the topoisomerase IIalpha promoter is inhibited by both the p53 tumor suppressor and anticancer drugs.
    Joshi AA; Wu Z; Reed RF; Suttle DP
    Mol Pharmacol; 2003 Feb; 63(2):359-67. PubMed ID: 12527807
    [TBL] [Abstract][Full Text] [Related]  

  • 6. HMGB1 and HMGB2 proteins up-regulate cellular expression of human topoisomerase IIalpha.
    Stros M; Polanská E; Struncová S; Pospísilová S
    Nucleic Acids Res; 2009 Apr; 37(7):2070-86. PubMed ID: 19223331
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Inhibition of DNA binding of the NF-Y transcription factor by the pyrrolobenzodiazepine-polyamide conjugate GWL-78.
    Kotecha M; Kluza J; Wells G; O'Hare CC; Forni C; Mantovani R; Howard PW; Morris P; Thurston DE; Hartley JA; Hochhauser D
    Mol Cancer Ther; 2008 May; 7(5):1319-28. PubMed ID: 18483319
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Effects of N-terminus modified Hx-amides on DNA binding affinity, sequence specificity, cellular uptake, and gene expression.
    Kiakos K; Satam V; Patil PC; Sweers J; Bowerman M; Tzou S; Olsen K; Lee M; Schaschl H; Keppler BK; Hochhauser D; Lee M; Hartley JA; Pett L
    Bioorg Med Chem Lett; 2021 Sep; 47():128158. PubMed ID: 34058343
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Novel regulation of nuclear factor-YB by miR-485-3p affects the expression of DNA topoisomerase IIα and drug responsiveness.
    Chen CF; He X; Arslan AD; Mo YY; Reinhold WC; Pommier Y; Beck WT
    Mol Pharmacol; 2011 Apr; 79(4):735-41. PubMed ID: 21252292
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Targeting the ICB2 site of the topoisomerase IIalpha promoter with a formamido-pyrrole-imidazole-pyrrole H-pin polyamide.
    Franks A; Tronrud C; Kiakos K; Kluza J; Munde M; Brown T; Mackay H; Wilson WD; Hochhauser D; Hartley JA; Lee M
    Bioorg Med Chem; 2010 Aug; 18(15):5553-61. PubMed ID: 20615712
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Decreased topoisomerase IIα expression and altered histone and regulatory factors of topoisomerase IIα promoter in patients with chronic benzene poisoning.
    Yu K; Shi YF; Yang KY; Zhuang Y; Zhu RH; Xu X; Cai G
    Toxicol Lett; 2011 Jun; 203(2):111-7. PubMed ID: 21382456
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Upregulation of topoisomerase IIalpha expression in advanced gallbladder carcinoma: a potential chemotherapeutic target.
    Washiro M; Ohtsuka M; Kimura F; Shimizu H; Yoshidome H; Sugimoto T; Seki N; Miyazaki M
    J Cancer Res Clin Oncol; 2008 Jul; 134(7):793-801. PubMed ID: 18204862
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Modulation of DNA topoisomerase II alpha promoter activity by members of the Sp (specificity protein) and NF-Y (nuclear factor Y) families of transcription factors.
    Magan N; Szremska AP; Isaacs RJ; Stowell KM
    Biochem J; 2003 Sep; 374(Pt 3):723-9. PubMed ID: 12769819
    [TBL] [Abstract][Full Text] [Related]  

  • 14. CBF/NF-Y functions both in nucleosomal disruption and transcription activation of the chromatin-assembled topoisomerase IIalpha promoter. Transcription activation by CBF/NF-Y in chromatin is dependent on the promoter structure.
    Coustry F; Hu Q; de Crombrugghe B; Maity SN
    J Biol Chem; 2001 Nov; 276(44):40621-30. PubMed ID: 11514576
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Targeting the inverted CCAAT Box-2 of the topoisomerase IIalpha gene: DNA sequence selective recognition by a polyamide-intercalator as a staggered dimer.
    Mackay H; Brown T; Sexton JS; Kotecha M; Nguyen B; Wilson WD; Kluza J; Savic B; O'Hare C; Hochhauser D; Lee M; Hartley JA
    Bioorg Med Chem; 2008 Feb; 16(4):2093-102. PubMed ID: 17977733
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Down-regulation of human topoisomerase IIalpha correlates with altered expression of transcriptional regulators NF-YA and Sp1.
    Allen KA; Williams AO; Isaacs RJ; Stowell KM
    Anticancer Drugs; 2004 Apr; 15(4):357-62. PubMed ID: 15057140
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Characterization of the human topoisomerase IIbeta (TOP2B) promoter activity: essential roles of the nuclear factor-Y (NF-Y)- and specificity protein-1 (Sp1)-binding sites.
    Lok CN; Lang AJ; Mirski SE; Cole SP
    Biochem J; 2002 Dec; 368(Pt 3):741-51. PubMed ID: 12197834
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Binding of f-PIP, a pyrrole- and imidazole-containing triamide, to the inverted CCAAT box-2 of the topoisomerase IIalpha promoter and modulation of gene expression in cells.
    Le NM; Sielaff AM; Cooper AJ; Mackay H; Brown T; Kotecha M; O'Hare C; Hochhauser D; Lee M; Hartley JA
    Bioorg Med Chem Lett; 2006 Dec; 16(24):6161-4. PubMed ID: 17011187
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Design of a hairpin polyamide, ZT65B, for targeting the inverted CCAAT box (ICB) site in the multidrug resistant (MDR1) gene.
    Buchmueller KL; Taherbhai Z; Howard CM; Bailey SL; Nguyen B; O'Hare C; Hochhauser D; Hartley JA; Wilson WD; Lee M
    Chembiochem; 2005 Dec; 6(12):2305-11. PubMed ID: 16254941
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cell-cycle regulation of the DNA topoisomerase IIalpha promoter is mediated by proximal CCAAT boxes: possible involvement of acetylation.
    Adachi N; Nomoto M; Kohno K; Koyama H
    Gene; 2000 Mar; 245(1):49-57. PubMed ID: 10713444
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 9.