BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

298 related articles for article (PubMed ID: 27764245)

  • 1. An Epigenetic Compound Library Screen Identifies BET Inhibitors That Promote HSV-1 and -2 Replication by Bridging P-TEFb to Viral Gene Promoters through BRD4.
    Ren K; Zhang W; Chen X; Ma Y; Dai Y; Fan Y; Hou Y; Tan RX; Li E
    PLoS Pathog; 2016 Oct; 12(10):e1005950. PubMed ID: 27764245
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Bromodomain and extra-terminal (BET) bromodomain inhibition activate transcription via transient release of positive transcription elongation factor b (P-TEFb) from 7SK small nuclear ribonucleoprotein.
    Bartholomeeusen K; Xiang Y; Fujinaga K; Peterlin BM
    J Biol Chem; 2012 Oct; 287(43):36609-16. PubMed ID: 22952229
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Bromodomain protein Brd4 regulates human immunodeficiency virus transcription through phosphorylation of CDK9 at threonine 29.
    Zhou M; Huang K; Jung KJ; Cho WK; Klase Z; Kashanchi F; Pise-Masison CA; Brady JN
    J Virol; 2009 Jan; 83(2):1036-44. PubMed ID: 18971272
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Transcriptional Elongation Control of Hepatitis B Virus Covalently Closed Circular DNA Transcription by Super Elongation Complex and BRD4.
    Francisco JC; Dai Q; Luo Z; Wang Y; Chong RH; Tan YJ; Xie W; Lee GH; Lin C
    Mol Cell Biol; 2017 Oct; 37(19):. PubMed ID: 28694331
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Suppression of BRD4 inhibits human hepatocellular carcinoma by repressing MYC and enhancing BIM expression.
    Li GQ; Guo WZ; Zhang Y; Seng JJ; Zhang HP; Ma XX; Zhang G; Li J; Yan B; Tang HW; Li SS; Wang LD; Zhang SJ
    Oncotarget; 2016 Jan; 7(3):2462-74. PubMed ID: 26575167
    [TBL] [Abstract][Full Text] [Related]  

  • 6. BET bromodomain-targeting compounds reactivate HIV from latency via a Tat-independent mechanism.
    Boehm D; Calvanese V; Dar RD; Xing S; Schroeder S; Martins L; Aull K; Li PC; Planelles V; Bradner JE; Zhou MM; Siliciano RF; Weinberger L; Verdin E; Ott M
    Cell Cycle; 2013 Feb; 12(3):452-62. PubMed ID: 23255218
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Compensatory RNA polymerase 2 loading determines the efficacy and transcriptional selectivity of JQ1 in Myc-driven tumors.
    Donato E; Croci O; Sabò A; Muller H; Morelli MJ; Pelizzola M; Campaner S
    Leukemia; 2017 Feb; 31(2):479-490. PubMed ID: 27443262
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Targeting BRD4 proteins suppresses the growth of NSCLC through downregulation of eIF4E expression.
    Gao Z; Yuan T; Zhou X; Ni P; Sun G; Li P; Cheng Z; Wang X
    Cancer Biol Ther; 2018 May; 19(5):407-415. PubMed ID: 29333921
    [TBL] [Abstract][Full Text] [Related]  

  • 9. The BET bromodomain inhibitor JQ1 activates HIV latency through antagonizing Brd4 inhibition of Tat-transactivation.
    Li Z; Guo J; Wu Y; Zhou Q
    Nucleic Acids Res; 2013 Jan; 41(1):277-87. PubMed ID: 23087374
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Affinity map of bromodomain protein 4 (BRD4) interactions with the histone H4 tail and the small molecule inhibitor JQ1.
    Jung M; Philpott M; Müller S; Schulze J; Badock V; Eberspächer U; Moosmayer D; Bader B; Schmees N; Fernández-Montalván A; Haendler B
    J Biol Chem; 2014 Mar; 289(13):9304-19. PubMed ID: 24497639
    [TBL] [Abstract][Full Text] [Related]  

  • 11. BET Bromodomain Blockade Mitigates Intimal Hyperplasia in Rat Carotid Arteries.
    Wang B; Zhang M; Takayama T; Shi X; Roenneburg DA; Kent KC; Guo LW
    EBioMedicine; 2015 Nov; 2(11):1650-61. PubMed ID: 26870791
    [TBL] [Abstract][Full Text] [Related]  

  • 12. The BET bromodomain inhibitor, JQ1, facilitates c-FLIP degradation and enhances TRAIL-induced apoptosis independent of BRD4 and c-Myc inhibition.
    Yao W; Yue P; Khuri FR; Sun SY
    Oncotarget; 2015 Oct; 6(33):34669-79. PubMed ID: 26415225
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Transcriptome analysis of dominant-negative Brd4 mutants identifies Brd4-specific target genes of small molecule inhibitor JQ1.
    Decker TM; Kluge M; Krebs S; Shah N; Blum H; Friedel CC; Eick D
    Sci Rep; 2017 May; 7(1):1684. PubMed ID: 28490802
    [TBL] [Abstract][Full Text] [Related]  

  • 14. The Brd4 acetyllysine-binding protein is involved in activation of polyomavirus JC.
    Wollebo HS; Bellizzi A; Cossari DH; Salkind J; Safak M; White MK
    J Neurovirol; 2016 Oct; 22(5):615-625. PubMed ID: 27007123
    [TBL] [Abstract][Full Text] [Related]  

  • 15. BET protein Brd4 activates transcription in neurons and BET inhibitor Jq1 blocks memory in mice.
    Korb E; Herre M; Zucker-Scharff I; Darnell RB; Allis CD
    Nat Neurosci; 2015 Oct; 18(10):1464-73. PubMed ID: 26301327
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Nanog requires BRD4 to maintain murine embryonic stem cell pluripotency and is suppressed by bromodomain inhibitor JQ1 together with Lefty1.
    Horne GA; Stewart HJ; Dickson J; Knapp S; Ramsahoye B; Chevassut T
    Stem Cells Dev; 2015 Apr; 24(7):879-91. PubMed ID: 25393219
    [TBL] [Abstract][Full Text] [Related]  

  • 17. RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia.
    Zuber J; Shi J; Wang E; Rappaport AR; Herrmann H; Sison EA; Magoon D; Qi J; Blatt K; Wunderlich M; Taylor MJ; Johns C; Chicas A; Mulloy JC; Kogan SC; Brown P; Valent P; Bradner JE; Lowe SW; Vakoc CR
    Nature; 2011 Aug; 478(7370):524-8. PubMed ID: 21814200
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Brd4 is essential for IL-1β-induced inflammation in human airway epithelial cells.
    Khan YM; Kirkham P; Barnes PJ; Adcock IM
    PLoS One; 2014; 9(4):e95051. PubMed ID: 24759736
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Bromodomain and extraterminal inhibitors block the Epstein-Barr virus lytic cycle at two distinct steps.
    Keck KM; Moquin SA; He A; Fernandez SG; Somberg JJ; Liu SM; Martinez DM; Miranda JL
    J Biol Chem; 2017 Aug; 292(32):13284-13295. PubMed ID: 28588024
    [TBL] [Abstract][Full Text] [Related]  

  • 20. JQ1, an inhibitor of the epigenetic reader BRD4, suppresses the bidirectional MYC-AP4 axis via multiple mechanisms.
    Choi SK; Hong SH; Kim HS; Shin CY; Nam SW; Choi WS; Han JW; You JS
    Oncol Rep; 2016 Feb; 35(2):1186-94. PubMed ID: 26573731
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 15.