BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

264 related articles for article (PubMed ID: 27783926)

  • 1. Interactions and cooperativity between P-glycoprotein structural domains determined by thermal unfolding provides insights into its solution structure and function.
    Yang Z; Zhou Q; Mok L; Singh A; Swartz DJ; Urbatsch IL; Brouillette CG
    Biochim Biophys Acta Biomembr; 2017 Jan; 1859(1):48-60. PubMed ID: 27783926
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Combined mutation of catalytic glutamate residues in the two nucleotide binding domains of P-glycoprotein generates a conformation that binds ATP and ADP tightly.
    Tombline G; Bartholomew LA; Urbatsch IL; Senior AE
    J Biol Chem; 2004 Jul; 279(30):31212-20. PubMed ID: 15159388
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Nucleotide-induced conformational changes in P-glycoprotein and in nucleotide binding site mutants monitored by trypsin sensitivity.
    Julien M; Gros P
    Biochemistry; 2000 Apr; 39(15):4559-68. PubMed ID: 10758006
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Substrate-induced conformational changes in the nucleotide-binding domains of lipid bilayer-associated P-glycoprotein during ATP hydrolysis.
    Zoghbi ME; Mok L; Swartz DJ; Singh A; Fendley GA; Urbatsch IL; Altenberg GA
    J Biol Chem; 2017 Dec; 292(50):20412-20424. PubMed ID: 29018094
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Properties of P-glycoprotein with mutations in the "catalytic carboxylate" glutamate residues.
    Tombline G; Bartholomew LA; Tyndall GA; Gimi K; Urbatsch IL; Senior AE
    J Biol Chem; 2004 Nov; 279(45):46518-26. PubMed ID: 15326176
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Allosteric Role of Substrate Occupancy Toward the Alignment of P-glycoprotein Nucleotide Binding Domains.
    Pan L; Aller SG
    Sci Rep; 2018 Oct; 8(1):14643. PubMed ID: 30279588
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Allosteric modulation bypasses the requirement for ATP hydrolysis in regenerating low affinity transition state conformation of human P-glycoprotein.
    Maki N; Moitra K; Ghosh P; Dey S
    J Biol Chem; 2006 Apr; 281(16):10769-77. PubMed ID: 16505485
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Conformational changes of P-glycoprotein by nucleotide binding.
    Wang G; Pincheira R; Zhang M; Zhang JT
    Biochem J; 1997 Dec; 328 ( Pt 3)(Pt 3):897-904. PubMed ID: 9396736
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structural studies on Mycobacterium tuberculosis HddA enzyme using small angle X-ray scattering and dynamics simulation techniques.
    Karan S; Behl A; Sagar A; Bandyopadhyay A; Saxena AK
    Int J Biol Macromol; 2021 Feb; 171():28-36. PubMed ID: 33412198
    [TBL] [Abstract][Full Text] [Related]  

  • 10. On the origin of large flexibility of P-glycoprotein in the inward-facing state.
    Wen PC; Verhalen B; Wilkens S; Mchaourab HS; Tajkhorshid E
    J Biol Chem; 2013 Jun; 288(26):19211-20. PubMed ID: 23658020
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Conformational changes of the bacterial type I ATP-binding cassette importer HisQMP2 at distinct steps of the catalytic cycle.
    Heuveling J; Frochaux V; Ziomkowska J; Wawrzinek R; Wessig P; Herrmann A; Schneider E
    Biochim Biophys Acta; 2014 Jan; 1838(1 Pt B):106-16. PubMed ID: 24021237
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Multiple transport-active binding sites are available for a single substrate on human P-glycoprotein (ABCB1).
    Chufan EE; Kapoor K; Sim HM; Singh S; Talele TT; Durell SR; Ambudkar SV
    PLoS One; 2013; 8(12):e82463. PubMed ID: 24349290
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Synergy between conserved ABC signature Ser residues in P-glycoprotein catalysis.
    Tombline G; Bartholomew L; Gimi K; Tyndall GA; Senior AE
    J Biol Chem; 2004 Feb; 279(7):5363-73. PubMed ID: 14638679
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Functionally similar vanadate-induced 8-azidoadenosine 5'-[alpha-(32)P]Diphosphate-trapped transition state intermediates of human P-glycoprotin are generated in the absence and presence of ATP hydrolysis.
    Sauna ZE; Smith MM; Muller M; Ambudkar SV
    J Biol Chem; 2001 Jun; 276(24):21199-208. PubMed ID: 11287418
    [TBL] [Abstract][Full Text] [Related]  

  • 15. P-glycoprotein function involves conformational transitions detectable by differential immunoreactivity.
    Mechetner EB; Schott B; Morse BS; Stein WD; Druley T; Davis KA; Tsuruo T; Roninson IB
    Proc Natl Acad Sci U S A; 1997 Nov; 94(24):12908-13. PubMed ID: 9371774
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Involvement of the "occluded nucleotide conformation" of P-glycoprotein in the catalytic pathway.
    Tombline G; Muharemagić A; White LB; Senior AE
    Biochemistry; 2005 Sep; 44(38):12879-86. PubMed ID: 16171403
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Importance of the conserved Walker B glutamate residues, 556 and 1201, for the completion of the catalytic cycle of ATP hydrolysis by human P-glycoprotein (ABCB1).
    Sauna ZE; Müller M; Peng XH; Ambudkar SV
    Biochemistry; 2002 Nov; 41(47):13989-4000. PubMed ID: 12437356
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Catalytic and structural properties of ATP-dependent caprolactamase from Pseudomonas jessenii.
    Marjanovic A; Rozeboom HJ; de Vries MS; Mayer C; Otzen M; Wijma HJ; Janssen DB
    Proteins; 2021 Sep; 89(9):1079-1098. PubMed ID: 33826169
    [TBL] [Abstract][Full Text] [Related]  

  • 19. The nucleotide-binding domains of P-glycoprotein. Functional symmetry in the isolated domain demonstrated by N-ethylmaleimide labelling.
    Berridge G; Walker JA; Callaghan R; Kerr ID
    Eur J Biochem; 2003 Apr; 270(7):1483-92. PubMed ID: 12654004
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Cloning, overexpression, purification, and characterization of the carboxyl-terminal nucleotide binding domain of P-glycoprotein.
    Sharma S; Rose DR
    J Biol Chem; 1995 Jun; 270(23):14085-93. PubMed ID: 7775470
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.