These tools will no longer be maintained as of December 31, 2024. Archived website can be found here. PubMed4Hh GitHub repository can be found here. Contact NLM Customer Service if you have questions.


BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

200 related articles for article (PubMed ID: 27805392)

  • 1. Discovery of G Protein-Biased D2 Dopamine Receptor Partial Agonists.
    Chen X; McCorvy JD; Fischer MG; Butler KV; Shen Y; Roth BL; Jin J
    J Med Chem; 2016 Dec; 59(23):10601-10618. PubMed ID: 27805392
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Structure-Functional Selectivity Relationship Studies on A-86929 Analogs and Small Aryl Fragments toward the Discovery of Biased Dopamine D1 Receptor Agonists.
    Li H; Mirabel R; Zimmerman J; Ghiviriga I; Phidd DK; Horenstein N; Urs NM
    ACS Chem Neurosci; 2022 Jun; 13(12):1818-1831. PubMed ID: 35658399
    [TBL] [Abstract][Full Text] [Related]  

  • 3. D
    Shen Y; McCorvy JD; Martini ML; Rodriguiz RM; Pogorelov VM; Ward KM; Wetsel WC; Liu J; Roth BL; Jin J
    J Med Chem; 2019 May; 62(9):4755-4771. PubMed ID: 30964661
    [TBL] [Abstract][Full Text] [Related]  

  • 4. Distinct cortical and striatal actions of a β-arrestin-biased dopamine D2 receptor ligand reveal unique antipsychotic-like properties.
    Urs NM; Gee SM; Pack TF; McCorvy JD; Evron T; Snyder JC; Yang X; Rodriguiz RM; Borrelli E; Wetsel WC; Jin J; Roth BL; O'Donnell P; Caron MG
    Proc Natl Acad Sci U S A; 2016 Dec; 113(50):E8178-E8186. PubMed ID: 27911814
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Structure-functional selectivity relationship studies of β-arrestin-biased dopamine D₂ receptor agonists.
    Chen X; Sassano MF; Zheng L; Setola V; Chen M; Bai X; Frye SV; Wetsel WC; Roth BL; Jin J
    J Med Chem; 2012 Aug; 55(16):7141-53. PubMed ID: 22845053
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Molecular dynamics simulation of biased agonists at the dopamine D2 receptor suggests the mechanism of receptor functional selectivity.
    Montgomery D; Campbell A; Sullivan HJ; Wu C
    J Biomol Struct Dyn; 2019 Aug; 37(12):3206-3225. PubMed ID: 30124143
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Receptor, Ligand and Transducer Contributions to Dopamine D2 Receptor Functional Selectivity.
    Peterson SM; Pack TF; Caron MG
    PLoS One; 2015; 10(10):e0141637. PubMed ID: 26516769
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Elucidation of G-protein and β-arrestin functional selectivity at the dopamine D2 receptor.
    Peterson SM; Pack TF; Wilkins AD; Urs NM; Urban DJ; Bass CE; Lichtarge O; Caron MG
    Proc Natl Acad Sci U S A; 2015 Jun; 112(22):7097-102. PubMed ID: 25964346
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Novel Bivalent Ligands Based on the Sumanirole Pharmacophore Reveal Dopamine D
    Bonifazi A; Yano H; Ellenberger MP; Muller L; Kumar V; Zou MF; Cai NS; Guerrero AM; Woods AS; Shi L; Newman AH
    J Med Chem; 2017 Apr; 60(7):2890-2907. PubMed ID: 28300398
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Discovery of β-arrestin-biased dopamine D2 ligands for probing signal transduction pathways essential for antipsychotic efficacy.
    Allen JA; Yost JM; Setola V; Chen X; Sassano MF; Chen M; Peterson S; Yadav PN; Huang XP; Feng B; Jensen NH; Che X; Bai X; Frye SV; Wetsel WC; Caron MG; Javitch JA; Roth BL; Jin J
    Proc Natl Acad Sci U S A; 2011 Nov; 108(45):18488-93. PubMed ID: 22025698
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Antipsychotic-Like Efficacy of Dopamine D
    Sahlholm K; Gómez-Soler M; Valle-León M; López-Cano M; Taura JJ; Ciruela F; Fernández-Dueñas V
    Mol Neurobiol; 2018 Jun; 55(6):4952-4958. PubMed ID: 28779351
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Phosphoproteomic Analysis of Dopamine D2 Receptor Signaling Reveals Interplay of G Protein- and β-Arrestin-Mediated Effects.
    Wenk D; Khan S; Ignatchenko V; Hübner H; Gmeiner P; Weikert D; Pischetsrieder M; Kislinger T
    J Proteome Res; 2023 Jan; 22(1):259-271. PubMed ID: 36508580
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Molecular determinants of biased agonism at the dopamine D₂ receptor.
    Weichert D; Banerjee A; Hiller C; Kling RC; Hübner H; Gmeiner P
    J Med Chem; 2015 Mar; 58(6):2703-17. PubMed ID: 25734236
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Discovery and characterization of a G protein-biased agonist that inhibits β-arrestin recruitment to the D2 dopamine receptor.
    Free RB; Chun LS; Moritz AE; Miller BN; Doyle TB; Conroy JL; Padron A; Meade JA; Xiao J; Hu X; Dulcey AE; Han Y; Duan L; Titus S; Bryant-Genevier M; Barnaeva E; Ferrer M; Javitch JA; Beuming T; Shi L; Southall NT; Marugan JJ; Sibley DR
    Mol Pharmacol; 2014 Jul; 86(1):96-105. PubMed ID: 24755247
    [TBL] [Abstract][Full Text] [Related]  

  • 15. β-Arrestin biased dopamine D2 receptor partial agonists: Synthesis and pharmacological evaluation.
    Männel B; Hübner H; Möller D; Gmeiner P
    Bioorg Med Chem; 2017 Oct; 25(20):5613-5628. PubMed ID: 28870802
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structure-Guided Screening for Functionally Selective D
    Männel B; Jaiteh M; Zeifman A; Randakova A; Möller D; Hübner H; Gmeiner P; Carlsson J
    ACS Chem Biol; 2017 Oct; 12(10):2652-2661. PubMed ID: 28846380
    [TBL] [Abstract][Full Text] [Related]  

  • 17. The dopamine D2 receptor can directly recruit and activate GRK2 without G protein activation.
    Pack TF; Orlen MI; Ray C; Peterson SM; Caron MG
    J Biol Chem; 2018 Apr; 293(16):6161-6171. PubMed ID: 29487132
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Chirality of Novel Bitopic Agonists Determines Unique Pharmacology at the Dopamine D3 Receptor.
    Adhikari P; Xie B; Semeano A; Bonifazi A; Battiti FO; Newman AH; Yano H; Shi L
    Biomolecules; 2021 Apr; 11(4):. PubMed ID: 33924613
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Engineered D2R Variants Reveal the Balanced and Biased Contributions of G-Protein and β-Arrestin to Dopamine-Dependent Functions.
    Rose SJ; Pack TF; Peterson SM; Payne K; Borrelli E; Caron MG
    Neuropsychopharmacology; 2018 Apr; 43(5):1164-1173. PubMed ID: 29068002
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Structure-Activity Investigation of a G Protein-Biased Agonist Reveals Molecular Determinants for Biased Signaling of the D
    Chun LS; Vekariya RH; Free RB; Li Y; Lin DT; Su P; Liu F; Namkung Y; Laporte SA; Moritz AE; Aubé J; Frankowski KJ; Sibley DR
    Front Synaptic Neurosci; 2018; 10():2. PubMed ID: 29515433
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 10.