BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

215 related articles for article (PubMed ID: 27811150)

  • 1. Serine Synthesis Helps Hypoxic Cancer Stem Cells Regulate Redox.
    Samanta D; Semenza GL
    Cancer Res; 2016 Nov; 76(22):6458-6462. PubMed ID: 27811150
    [TBL] [Abstract][Full Text] [Related]  

  • 2. PHGDH Expression Is Required for Mitochondrial Redox Homeostasis, Breast Cancer Stem Cell Maintenance, and Lung Metastasis.
    Samanta D; Park Y; Andrabi SA; Shelton LM; Gilkes DM; Semenza GL
    Cancer Res; 2016 Aug; 76(15):4430-42. PubMed ID: 27280394
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Repression of phosphoglycerate dehydrogenase sensitizes triple-negative breast cancer to doxorubicin.
    Zhang X; Bai W
    Cancer Chemother Pharmacol; 2016 Sep; 78(3):655-9. PubMed ID: 27473325
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The PHGDH enigma: Do cancer cells only need serine or also a redox modulator?
    Li AM; Ye J
    Cancer Lett; 2020 Apr; 476():97-105. PubMed ID: 32032680
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Functional genomics reveal that the serine synthesis pathway is essential in breast cancer.
    Possemato R; Marks KM; Shaul YD; Pacold ME; Kim D; Birsoy K; Sethumadhavan S; Woo HK; Jang HG; Jha AK; Chen WW; Barrett FG; Stransky N; Tsun ZY; Cowley GS; Barretina J; Kalaany NY; Hsu PP; Ottina K; Chan AM; Yuan B; Garraway LA; Root DE; Mino-Kenudson M; Brachtel EF; Driggers EM; Sabatini DM
    Nature; 2011 Aug; 476(7360):346-50. PubMed ID: 21760589
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Phosphoglycerate dehydrogenase promotes pancreatic cancer development by interacting with eIF4A1 and eIF4E.
    Ma X; Li B; Liu J; Fu Y; Luo Y
    J Exp Clin Cancer Res; 2019 Feb; 38(1):66. PubMed ID: 30744688
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Serine synthesis pathway enzyme PHGDH is critical for muscle cell biomass, anabolic metabolism, and mTORC1 signaling.
    Mäntyselkä S; Kolari K; Baumert P; Ylä-Outinen L; Kuikka L; Lahtonen S; Permi P; Wackerhage H; Kalenius E; Kivelä R; Hulmi JJ
    Am J Physiol Endocrinol Metab; 2024 Jan; 326(1):E73-E91. PubMed ID: 37991454
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Inhibiting phosphoglycerate dehydrogenase counteracts chemotherapeutic efficacy against MYCN-amplified neuroblastoma.
    Arlt B; Zasada C; Baum K; Wuenschel J; Mastrobuoni G; Lodrini M; Astrahantseff K; Winkler A; Schulte JH; Finkler S; Forbes M; Hundsdoerfer P; Guergen D; Hoffmann J; Wolf J; Eggert A; Kempa S; Deubzer HE
    Int J Cancer; 2021 Mar; 148(5):1219-1232. PubMed ID: 33284994
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarate.
    Fan J; Teng X; Liu L; Mattaini KR; Looper RE; Vander Heiden MG; Rabinowitz JD
    ACS Chem Biol; 2015 Feb; 10(2):510-6. PubMed ID: 25406093
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The Role of D-3-Phosphoglycerate Dehydrogenase in Cancer.
    Zhao X; Fu J; Du J; Xu W
    Int J Biol Sci; 2020; 16(9):1495-1506. PubMed ID: 32226297
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Serine-dependent redox homeostasis regulates glioblastoma cell survival.
    Engel AL; Lorenz NI; Klann K; Münch C; Depner C; Steinbach JP; Ronellenfitsch MW; Luger AL
    Br J Cancer; 2020 Apr; 122(9):1391-1398. PubMed ID: 32203214
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Parkin ubiquitinates phosphoglycerate dehydrogenase to suppress serine synthesis and tumor progression.
    Liu J; Zhang C; Wu H; Sun XX; Li Y; Huang S; Yue X; Lu SE; Shen Z; Su X; White E; Haffty BG; Hu W; Feng Z
    J Clin Invest; 2020 Jun; 130(6):3253-3269. PubMed ID: 32478681
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Identification of a small molecule inhibitor of 3-phosphoglycerate dehydrogenase to target serine biosynthesis in cancers.
    Mullarky E; Lucki NC; Beheshti Zavareh R; Anglin JL; Gomes AP; Nicolay BN; Wong JC; Christen S; Takahashi H; Singh PK; Blenis J; Warren JD; Fendt SM; Asara JM; DeNicola GM; Lyssiotis CA; Lairson LL; Cantley LC
    Proc Natl Acad Sci U S A; 2016 Feb; 113(7):1778-83. PubMed ID: 26831078
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Validating and enabling phosphoglycerate dehydrogenase (PHGDH) as a target for fragment-based drug discovery in PHGDH-amplified breast cancer.
    Unterlass JE; Baslé A; Blackburn TJ; Tucker J; Cano C; Noble MEM; Curtin NJ
    Oncotarget; 2018 Mar; 9(17):13139-13153. PubMed ID: 29568346
    [TBL] [Abstract][Full Text] [Related]  

  • 15. PRMT1 Sustains De Novo Fatty Acid Synthesis by Methylating PHGDH to Drive Chemoresistance in Triple-Negative Breast Cancer.
    Yamamoto T; Hayashida T; Masugi Y; Oshikawa K; Hayakawa N; Itoh M; Nishime C; Suzuki M; Nagayama A; Kawai Y; Hishiki T; Matsuura T; Naito Y; Kubo A; Yamamoto A; Yoshioka Y; Kurahori T; Nagasaka M; Takizawa M; Takano N; Kawakami K; Sakamoto M; Wakui M; Yamamoto T; Kitagawa Y; Kabe Y; Horisawa K; Suzuki A; Matsumoto M; Suematsu M
    Cancer Res; 2024 Apr; 84(7):1065-1083. PubMed ID: 38383964
    [TBL] [Abstract][Full Text] [Related]  

  • 16. ASS1 inhibits triple-negative breast cancer by regulating PHGDH stability and de novo serine synthesis.
    Luo W; Zou Z; Nie Y; Luo J; Ming Z; Hu X; Luo T; Ouyang M; Liu M; Tang H; Xie Y; Peng K; Chen L; Zhou J; Luo Z
    Cell Death Dis; 2024 May; 15(5):319. PubMed ID: 38710705
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Serine Synthesis via PHGDH Is Essential for Heme Production in Endothelial Cells.
    Vandekeere S; Dubois C; Kalucka J; Sullivan MR; García-Caballero M; Goveia J; Chen R; Diehl FF; Bar-Lev L; Souffreau J; Pircher A; Kumar S; Vinckier S; Hirabayashi Y; Furuya S; Schoonjans L; Eelen G; Ghesquière B; Keshet E; Li X; Vander Heiden MG; Dewerchin M; Carmeliet P
    Cell Metab; 2018 Oct; 28(4):573-587.e13. PubMed ID: 30017355
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Inhibition of 3-phosphoglycerate dehydrogenase (PHGDH) by indole amides abrogates de novo serine synthesis in cancer cells.
    Mullarky E; Xu J; Robin AD; Huggins DJ; Jennings A; Noguchi N; Olland A; Lakshminarasimhan D; Miller M; Tomita D; Michino M; Su T; Zhang G; Stamford AW; Meinke PT; Kargman S; Cantley LC
    Bioorg Med Chem Lett; 2019 Sep; 29(17):2503-2510. PubMed ID: 31327531
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Parkin on serine: a Parkinson disease gene suppresses serine synthesis in cancer.
    Dalton WB
    J Clin Invest; 2020 Jun; 130(6):2820-2822. PubMed ID: 32420915
    [TBL] [Abstract][Full Text] [Related]  

  • 20. 3-Phosphoglycerate Transhydrogenation Instead of Dehydrogenation Alleviates the Redox State Dependency of Yeast de Novo l-Serine Synthesis.
    Paczia N; Becker-Kettern J; Conrotte JF; Cifuente JO; Guerin ME; Linster CL
    Biochemistry; 2019 Jan; 58(4):259-275. PubMed ID: 30668112
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 11.