178 related articles for article (PubMed ID: 27821594)
1. General Anesthetic Binding Sites in Human α4β3δ γ-Aminobutyric Acid Type A Receptors (GABAARs).
Chiara DC; Jounaidi Y; Zhou X; Savechenkov PY; Bruzik KS; Miller KW; Cohen JB
J Biol Chem; 2016 Dec; 291(51):26529-26539. PubMed ID: 27821594
[TBL] [Abstract][Full Text] [Related]
2. Multiple propofol-binding sites in a γ-aminobutyric acid type A receptor (GABAAR) identified using a photoreactive propofol analog.
Jayakar SS; Zhou X; Chiara DC; Dostalova Z; Savechenkov PY; Bruzik KS; Dailey WP; Miller KW; Eckenhoff RG; Cohen JB
J Biol Chem; 2014 Oct; 289(40):27456-68. PubMed ID: 25086038
[TBL] [Abstract][Full Text] [Related]
3. Specificity of intersubunit general anesthetic-binding sites in the transmembrane domain of the human α1β3γ2 γ-aminobutyric acid type A (GABAA) receptor.
Chiara DC; Jayakar SS; Zhou X; Zhang X; Savechenkov PY; Bruzik KS; Miller KW; Cohen JB
J Biol Chem; 2013 Jul; 288(27):19343-57. PubMed ID: 23677991
[TBL] [Abstract][Full Text] [Related]
4. Positive and Negative Allosteric Modulation of an α1β3γ2 γ-Aminobutyric Acid Type A (GABAA) Receptor by Binding to a Site in the Transmembrane Domain at the γ+-β- Interface.
Jayakar SS; Zhou X; Savechenkov PY; Chiara DC; Desai R; Bruzik KS; Miller KW; Cohen JB
J Biol Chem; 2015 Sep; 290(38):23432-46. PubMed ID: 26229099
[TBL] [Abstract][Full Text] [Related]
5. Enantiomeric barbiturates bind distinct inter- and intrasubunit binding sites in a nicotinic acetylcholine receptor (nAChR).
Yu Z; Cohen JB
J Biol Chem; 2017 Oct; 292(42):17258-17271. PubMed ID: 28878016
[TBL] [Abstract][Full Text] [Related]
6. Identifying barbiturate binding sites in a nicotinic acetylcholine receptor with [3H]allyl m-trifluoromethyldiazirine mephobarbital, a photoreactive barbiturate.
Hamouda AK; Stewart DS; Chiara DC; Savechenkov PY; Bruzik KS; Cohen JB
Mol Pharmacol; 2014 May; 85(5):735-46. PubMed ID: 24563544
[TBL] [Abstract][Full Text] [Related]
7. Mapping general anesthetic binding site(s) in human α1β3 γ-aminobutyric acid type A receptors with [³H]TDBzl-etomidate, a photoreactive etomidate analogue.
Chiara DC; Dostalova Z; Jayakar SS; Zhou X; Miller KW; Cohen JB
Biochemistry; 2012 Jan; 51(4):836-47. PubMed ID: 22243422
[TBL] [Abstract][Full Text] [Related]
8. Identifying Drugs that Bind Selectively to Intersubunit General Anesthetic Sites in the
Jayakar SS; Zhou X; Chiara DC; Jarava-Barrera C; Savechenkov PY; Bruzik KS; Tortosa M; Miller KW; Cohen JB
Mol Pharmacol; 2019 Jun; 95(6):615-628. PubMed ID: 30952799
[TBL] [Abstract][Full Text] [Related]
9. Contrasting Effects of the γ-Aminobutyric Acid Type A Receptor β3 Subunit N265M Mutation on Loss of Righting Reflexes Induced by Etomidate and the Novel Anesthetic Barbiturate R-mTFD-MPAB.
Amlong CA; Perkins MG; Houle TT; Miller KW; Pearce RA
Anesth Analg; 2016 Nov; 123(5):1241-1246. PubMed ID: 27331778
[TBL] [Abstract][Full Text] [Related]
10. Identification of a GABAA receptor anesthetic binding site at subunit interfaces by photolabeling with an etomidate analog.
Li GD; Chiara DC; Sawyer GW; Husain SS; Olsen RW; Cohen JB
J Neurosci; 2006 Nov; 26(45):11599-605. PubMed ID: 17093081
[TBL] [Abstract][Full Text] [Related]
11. Synthesis and pharmacological evaluation of neurosteroid photoaffinity ligands.
Savechenkov PY; Chiara DC; Desai R; Stern AT; Zhou X; Ziemba AM; Szabo AL; Zhang Y; Cohen JB; Forman SA; Miller KW; Bruzik KS
Eur J Med Chem; 2017 Aug; 136():334-347. PubMed ID: 28505538
[TBL] [Abstract][Full Text] [Related]
12. A potent photoreactive general anesthetic with novel binding site selectivity for GABA
Shalabi AR; Yu Z; Zhou X; Jounaidi Y; Chen H; Dai J; Kent DE; Feng HJ; Forman SA; Cohen JB; Bruzik KS; Miller KW
Eur J Med Chem; 2020 May; 194():112261. PubMed ID: 32247113
[TBL] [Abstract][Full Text] [Related]
13. Neurosteroids allosterically modulate binding of the anesthetic etomidate to gamma-aminobutyric acid type A receptors.
Li GD; Chiara DC; Cohen JB; Olsen RW
J Biol Chem; 2009 May; 284(18):11771-5. PubMed ID: 19282280
[TBL] [Abstract][Full Text] [Related]
14. Photoaffinity labeling identifies an intersubunit steroid-binding site in heteromeric GABA type A (GABA
Jayakar SS; Chiara DC; Zhou X; Wu B; Bruzik KS; Miller KW; Cohen JB
J Biol Chem; 2020 Aug; 295(33):11495-11512. PubMed ID: 32540960
[TBL] [Abstract][Full Text] [Related]
15. Numerous classes of general anesthetics inhibit etomidate binding to gamma-aminobutyric acid type A (GABAA) receptors.
Li GD; Chiara DC; Cohen JB; Olsen RW
J Biol Chem; 2010 Mar; 285(12):8615-20. PubMed ID: 20083606
[TBL] [Abstract][Full Text] [Related]
16. A Cysteine Substitution Probes β3H267 Interactions with Propofol and Other Potent Anesthetics in α1β3γ2L γ-Aminobutyric Acid Type A Receptors.
Stern AT; Forman SA
Anesthesiology; 2016 Jan; 124(1):89-100. PubMed ID: 26569173
[TBL] [Abstract][Full Text] [Related]
17. Comparison of αβδ and αβγ GABA
Feng HJ; Forman SA
Pharmacol Res; 2018 Jul; 133():289-300. PubMed ID: 29294355
[TBL] [Abstract][Full Text] [Related]
18. Photomotor Responses in Zebrafish and Electrophysiology Reveal Varying Interactions of Anesthetics Targeting Distinct Sites on γ-Aminobutyric Acid Type A Receptors.
Hoyt H; Fantasia RJ; Bhave K; Yang X; Forman SA
Anesthesiology; 2022 Nov; 137(5):568-585. PubMed ID: 36018576
[TBL] [Abstract][Full Text] [Related]
19. Inhibitable photolabeling by neurosteroid diazirine analog in the β3-Subunit of human hetereopentameric type A GABA receptors.
Wu B; Jayakar SS; Zhou X; Titterton K; Chiara DC; Szabo AL; Savechenkov PY; Kent DE; Cohen JB; Forman SA; Miller KW; Bruzik KS
Eur J Med Chem; 2019 Jan; 162():810-824. PubMed ID: 30544077
[TBL] [Abstract][Full Text] [Related]
20. Monod-Wyman-Changeux Allosteric Shift Analysis in Mutant
Szabo A; Nourmahnad A; Halpin E; Forman SA
Mol Pharmacol; 2019 Apr; 95(4):408-417. PubMed ID: 30696720
[TBL] [Abstract][Full Text] [Related]
[Next] [New Search]