BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

242 related articles for article (PubMed ID: 27825049)

  • 1. Crystal structure of a polypeptide's C-terminus in complex with the regulatory domain of ER aminopeptidase 1.
    Sui L; Gandhi A; Guo HC
    Mol Immunol; 2016 Dec; 80():41-49. PubMed ID: 27825049
    [TBL] [Abstract][Full Text] [Related]  

  • 2. ERAP1 binds peptide C-termini of different sequences and/or lengths by a common recognition mechanism.
    Sui L; Guo HC
    Immunobiology; 2021 Jul; 226(4):152112. PubMed ID: 34247019
    [TBL] [Abstract][Full Text] [Related]  

  • 3. The internal sequence of the peptide-substrate determines its N-terminus trimming by ERAP1.
    Evnouchidou I; Momburg F; Papakyriakou A; Chroni A; Leondiadis L; Chang SC; Goldberg AL; Stratikos E
    PLoS One; 2008; 3(11):e3658. PubMed ID: 18987748
    [TBL] [Abstract][Full Text] [Related]  

  • 4. The ER aminopeptidase, ERAP1, trims precursors to lengths of MHC class I peptides by a "molecular ruler" mechanism.
    Chang SC; Momburg F; Bhutani N; Goldberg AL
    Proc Natl Acad Sci U S A; 2005 Nov; 102(47):17107-12. PubMed ID: 16286653
    [TBL] [Abstract][Full Text] [Related]  

  • 5. The partial dissociation of MHC class I-bound peptides exposes their N terminus to trimming by endoplasmic reticulum aminopeptidase 1.
    Papakyriakou A; Reeves E; Beton M; Mikolajek H; Douglas L; Cooper G; Elliott T; Werner JM; James E
    J Biol Chem; 2018 May; 293(20):7538-7548. PubMed ID: 29599287
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Structural insights into the molecular ruler mechanism of the endoplasmic reticulum aminopeptidase ERAP1.
    Gandhi A; Lakshminarasimhan D; Sun Y; Guo HC
    Sci Rep; 2011; 1():186. PubMed ID: 22355701
    [TBL] [Abstract][Full Text] [Related]  

  • 7. Structure-guided discovery of aminopeptidase ERAP1 variants capable of processing antigens with novel PC anchor specificities.
    Pande S; Guo HC
    Immunology; 2024 Jan; 171(1):131-145. PubMed ID: 37858978
    [TBL] [Abstract][Full Text] [Related]  

  • 8. ERAP1 enzyme-mediated trimming and structural analyses of MHC I-bound precursor peptides yield novel insights into antigen processing and presentation.
    Li L; Batliwala M; Bouvier M
    J Biol Chem; 2019 Dec; 294(49):18534-18544. PubMed ID: 31601650
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structural Basis for Antigenic Peptide Recognition and Processing by Endoplasmic Reticulum (ER) Aminopeptidase 2.
    Mpakali A; Giastas P; Mathioudakis N; Mavridis IM; Saridakis E; Stratikos E
    J Biol Chem; 2015 Oct; 290(43):26021-32. PubMed ID: 26381406
    [TBL] [Abstract][Full Text] [Related]  

  • 10. The crystal structure of human endoplasmic reticulum aminopeptidase 2 reveals the atomic basis for distinct roles in antigen processing.
    Birtley JR; Saridakis E; Stratikos E; Mavridis IM
    Biochemistry; 2012 Jan; 51(1):286-95. PubMed ID: 22106953
    [TBL] [Abstract][Full Text] [Related]  

  • 11. A systematic re-examination of processing of MHCI-bound antigenic peptide precursors by endoplasmic reticulum aminopeptidase 1.
    Mavridis G; Arya R; Domnick A; Zoidakis J; Makridakis M; Vlahou A; Mpakali A; Lelis A; Georgiadis D; Tampé R; Papakyriakou A; Stern LJ; Stratikos E
    J Biol Chem; 2020 May; 295(21):7193-7210. PubMed ID: 32184355
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Critical Role of Interdomain Interactions in the Conformational Change and Catalytic Mechanism of Endoplasmic Reticulum Aminopeptidase 1.
    Stamogiannos A; Maben Z; Papakyriakou A; Mpakali A; Kokkala P; Georgiadis D; Stern LJ; Stratikos E
    Biochemistry; 2017 Mar; 56(10):1546-1558. PubMed ID: 28218509
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Targeting the Regulatory Site of ER Aminopeptidase 1 Leads to the Discovery of a Natural Product Modulator of Antigen Presentation.
    Liddle J; Hutchinson JP; Kitchen S; Rowland P; Neu M; Cecconie T; Holmes DS; Jones E; Korczynska J; Koumantou D; Lea JD; Nickels L; Pemberton M; Phillipou A; Schneck JL; Sheehan H; Tinworth CP; Uings I; Wojno-Picon J; Young RJ; Stratikos E
    J Med Chem; 2020 Mar; 63(6):3348-3358. PubMed ID: 32109056
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Endoplasmic reticulum aminopeptidase 1 (ERAP1) trims MHC class I-presented peptides in vivo and plays an important role in immunodominance.
    York IA; Brehm MA; Zendzian S; Towne CF; Rock KL
    Proc Natl Acad Sci U S A; 2006 Jun; 103(24):9202-7. PubMed ID: 16754858
    [TBL] [Abstract][Full Text] [Related]  

  • 15. Editing the immunopeptidome of melanoma cells using a potent inhibitor of endoplasmic reticulum aminopeptidase 1 (ERAP1).
    Koumantou D; Barnea E; Martin-Esteban A; Maben Z; Papakyriakou A; Mpakali A; Kokkala P; Pratsinis H; Georgiadis D; Stern LJ; Admon A; Stratikos E
    Cancer Immunol Immunother; 2019 Aug; 68(8):1245-1261. PubMed ID: 31222486
    [TBL] [Abstract][Full Text] [Related]  

  • 16. Structural basis for antigenic peptide precursor processing by the endoplasmic reticulum aminopeptidase ERAP1.
    Nguyen TT; Chang SC; Evnouchidou I; York IA; Zikos C; Rock KL; Goldberg AL; Stratikos E; Stern LJ
    Nat Struct Mol Biol; 2011 May; 18(5):604-13. PubMed ID: 21478864
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Placental leucine aminopeptidase efficiently generates mature antigenic peptides in vitro but in patterns distinct from endoplasmic reticulum aminopeptidase 1.
    Georgiadou D; Hearn A; Evnouchidou I; Chroni A; Leondiadis L; York IA; Rock KL; Stratikos E
    J Immunol; 2010 Aug; 185(3):1584-92. PubMed ID: 20592285
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Molecular pathways for antigenic peptide generation by ER aminopeptidase 1.
    Mpakali A; Maben Z; Stern LJ; Stratikos E
    Mol Immunol; 2019 Sep; 113():50-57. PubMed ID: 29678301
    [TBL] [Abstract][Full Text] [Related]  

  • 19. ERAP1-ERAP2 dimers trim MHC I-bound precursor peptides; implications for understanding peptide editing.
    Chen H; Li L; Weimershaus M; Evnouchidou I; van Endert P; Bouvier M
    Sci Rep; 2016 Aug; 6():28902. PubMed ID: 27514473
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Conformational dynamics linked to domain closure and substrate binding explain the ERAP1 allosteric regulation mechanism.
    Maben Z; Arya R; Georgiadis D; Stratikos E; Stern LJ
    Nat Commun; 2021 Sep; 12(1):5302. PubMed ID: 34489420
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 13.