BIOMARKERS

Molecular Biopsy of Human Tumors

- a resource for Precision Medicine *

265 related articles for article (PubMed ID: 27848066)

  • 1. Molecular mechanism of R-bicalutamide switching from androgen receptor antagonist to agonist induced by amino acid mutations using molecular dynamics simulations and free energy calculation.
    Liu H; Han R; Li J; Liu H; Zheng L
    J Comput Aided Mol Des; 2016 Dec; 30(12):1189-1200. PubMed ID: 27848066
    [TBL] [Abstract][Full Text] [Related]  

  • 2. Interaction mechanism exploration of R-bicalutamide/S-1 with WT/W741L AR using molecular dynamics simulations.
    Liu H; An X; Li S; Wang Y; Li J; Liu H
    Mol Biosyst; 2015 Dec; 11(12):3347-54. PubMed ID: 26442831
    [TBL] [Abstract][Full Text] [Related]  

  • 3. Molecular Dynamics Studies on the Enzalutamide Resistance Mechanisms Induced by Androgen Receptor Mutations.
    Liu H; Wang L; Tian J; Li J; Liu H
    J Cell Biochem; 2017 Sep; 118(9):2792-2801. PubMed ID: 28181296
    [TBL] [Abstract][Full Text] [Related]  

  • 4. A Molecular Modeling Study of the Hydroxyflutamide Resistance Mechanism Induced by Androgen Receptor Mutations.
    Liu HL; Zhong HY; Song TQ; Li JZ
    Int J Mol Sci; 2017 Aug; 18(9):. PubMed ID: 28832499
    [TBL] [Abstract][Full Text] [Related]  

  • 5. Learning from estrogen receptor antagonism: structure-based identification of novel antiandrogens effective against multiple clinically relevant androgen receptor mutants.
    Liu B; Geng G; Lin R; Ren C; Wu JH
    Chem Biol Drug Des; 2012 Mar; 79(3):300-12. PubMed ID: 22151347
    [TBL] [Abstract][Full Text] [Related]  

  • 6. Mechanism of androgen receptor antagonism by bicalutamide in the treatment of prostate cancer.
    Osguthorpe DJ; Hagler AT
    Biochemistry; 2011 May; 50(19):4105-13. PubMed ID: 21466228
    [TBL] [Abstract][Full Text] [Related]  

  • 7. CH5137291, an androgen receptor nuclear translocation-inhibiting compound, inhibits the growth of castration-resistant prostate cancer cells.
    Ishikura N; Kawata H; Nishimoto A; Nakamura R; Tsunenari T; Watanabe M; Tachibana K; Shiraishi T; Yoshino H; Honma A; Emura T; Ohta M; Nakagawa T; Houjo T; Corey E; Vessella RL; Aoki Y; Sato H
    Int J Oncol; 2015 Apr; 46(4):1560-72. PubMed ID: 25634071
    [TBL] [Abstract][Full Text] [Related]  

  • 8. Novel mutations of androgen receptor: a possible mechanism of bicalutamide withdrawal syndrome.
    Hara T; Miyazaki J; Araki H; Yamaoka M; Kanzaki N; Kusaka M; Miyamoto M
    Cancer Res; 2003 Jan; 63(1):149-53. PubMed ID: 12517791
    [TBL] [Abstract][Full Text] [Related]  

  • 9. Structural Dynamics of Agonist and Antagonist Binding to the Androgen Receptor.
    Azhagiya Singam ER; Tachachartvanich P; La Merrill MA; Smith MT; Durkin KA
    J Phys Chem B; 2019 Sep; 123(36):7657-7666. PubMed ID: 31431014
    [TBL] [Abstract][Full Text] [Related]  

  • 10. Conformational dynamics of androgen receptors bound to agonists and antagonists.
    Gim HJ; Park J; Jung ME; Houk KN
    Sci Rep; 2021 Aug; 11(1):15887. PubMed ID: 34354111
    [TBL] [Abstract][Full Text] [Related]  

  • 11. Molecular basis of agonicity and antagonicity in the androgen receptor studied by molecular dynamics simulations.
    Bisson WH; Abagyan R; Cavasotto CN
    J Mol Graph Model; 2008 Nov; 27(4):452-8. PubMed ID: 18805032
    [TBL] [Abstract][Full Text] [Related]  

  • 12. Activity of androgen receptor antagonist bicalutamide in prostate cancer cells is independent of NCoR and SMRT corepressors.
    Hodgson MC; Astapova I; Hollenberg AN; Balk SP
    Cancer Res; 2007 Sep; 67(17):8388-95. PubMed ID: 17804755
    [TBL] [Abstract][Full Text] [Related]  

  • 13. Structural basis for antagonism and resistance of bicalutamide in prostate cancer.
    Bohl CE; Gao W; Miller DD; Bell CE; Dalton JT
    Proc Natl Acad Sci U S A; 2005 Apr; 102(17):6201-6. PubMed ID: 15833816
    [TBL] [Abstract][Full Text] [Related]  

  • 14. Study of the impact of the T877A mutation on ligand-induced helix-12 positioning of the androgen receptor resulted in design and synthesis of novel antiandrogens.
    Zhou J; Liu B; Geng G; Wu JH
    Proteins; 2010 Feb; 78(3):623-37. PubMed ID: 19787772
    [TBL] [Abstract][Full Text] [Related]  

  • 15. The fluorescent two-hybrid assay for live-cell profiling of androgen receptor modulators.
    Bogner J; Zolghadr K; Hickson I; Romer T; Yurlova L
    J Steroid Biochem Mol Biol; 2017 Feb; 166():45-53. PubMed ID: 27174722
    [TBL] [Abstract][Full Text] [Related]  

  • 16. The androgen receptor T877A mutant recruits LXXLL and FXXLF peptides differently than wild-type androgen receptor in a time-resolved fluorescence resonance energy transfer assay.
    Ozers MS; Marks BD; Gowda K; Kupcho KR; Ervin KM; De Rosier T; Qadir N; Eliason HC; Riddle SM; Shekhani MS
    Biochemistry; 2007 Jan; 46(3):683-95. PubMed ID: 17223690
    [TBL] [Abstract][Full Text] [Related]  

  • 17. Molecular dynamics simulations reveal the plausible agonism/antagonism mechanism by steroids on androgen receptor mutations.
    Kocak A; Yildiz M
    J Mol Graph Model; 2022 Mar; 111():108081. PubMed ID: 34826715
    [TBL] [Abstract][Full Text] [Related]  

  • 18. Effects of steroidal and non-steroidal antiandrogens on wild-type and mutant androgen receptors.
    Urushibara M; Ishioka J; Hyochi N; Kihara K; Hara S; Singh P; Isaacs JT; Kageyama Y
    Prostate; 2007 Jun; 67(8):799-807. PubMed ID: 17373727
    [TBL] [Abstract][Full Text] [Related]  

  • 19. Molecular Dynamics Simulations Revealed the Regulation of Ligands to the Interactions between Androgen Receptor and Its Coactivator.
    Liu N; Zhou W; Guo Y; Wang J; Fu W; Sun H; Li D; Duan M; Hou T
    J Chem Inf Model; 2018 Aug; 58(8):1652-1661. PubMed ID: 29993249
    [TBL] [Abstract][Full Text] [Related]  

  • 20. Chemical Degradation of Androgen Receptor (AR) Using Bicalutamide Analog-Thalidomide PROTACs.
    Kim GY; Song CW; Yang YS; Lee NR; Yoo HS; Son SH; Lee SJ; Park JS; Lee JK; Inn KS; Kim NJ
    Molecules; 2021 Apr; 26(9):. PubMed ID: 33926033
    [TBL] [Abstract][Full Text] [Related]  

    [Next]    [New Search]
    of 14.